Cited by 366Stress Responses and CortisolAdrenal Hormones and DisordersAdipokines, Inflammation, and Metabolic Diseases

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The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution

Pasquali, R, Cantobelli, S, Casimirri, F, Capelli, M, Bortoluzzi, L, Flamia, R, Labate, A M, Barbara, L·1993·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem.77.2.8393881

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Abstract

To investigate whether obese subjects with abdominal obesity may be characterized by hyperactivity of the hypothalamic-pituitary-adrenal axis, we examined two groups of obese women with a waist to hip ratio (WHR) lower than 0.80 (n = 13), therefore having peripheral body fat distribution (P-BFD), or a WHR higher than 0.85 (n = 12), thus having abdominal body fat distribution (A-BFD). A group of seven normal weight healthy women served as controls. All subjects underwent the following protocol study that included 1) measurement of daily urinary free cortisol excretion rate; 2) a CRF test (human CRF, 1 microgram/kg BW, as iv bolus), with blood samples taken at regular intervals for ACTH and cortisol determination; and 3) an ACTH test, performed by administering two boli of ACTH (Synacthen, 0.2 microgram/kg BW, iv), at 90-min intervals, with blood samples taken for cortisol determination. Each woman also had a control saline study. Basal levels of both ACTH and cortisol rose significantly after CRF administration in all groups, but this increase was significantly higher in A-BFD than in P-BFD and control women. A significant correlation was found between the incremental area of cortisol and that of ACTH during the CRF test (r = 0.502), but not between these parameters and WHR values. Although the cortisol increase after the ACTH test was higher in A-BFD than in the other groups, these differences were only significant at 60 min during the test and when the analysis for repeated…

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Authors: Pasquali, R., Cantobelli, S., Casimirri, F., Capelli, M., Bortoluzzi, L., Flamia, R., Labate, A. M., & Barbara, L.
Affiliations: IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1993-08
Volume: 77
Issue: 2
Pages: 341-346
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem.77.2.8393881
OpenAlex: W2131857378
Cited by: 366
References: 0
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 13 · 2015: 10 · 2014: 11 · 2013: 13 · 2012: 17
FWCI: 6.01
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: hypothalamic-pituitary-adrenal axis, obesity, abdominal obesity, waist-to-hip ratio, cortisol, ACTH, corticotropin-releasing factor, urinary free cortisol, cortisol resistance, women
MeSH terms: Abdomen, Adipose Tissue, Adrenocorticotropic Hormone, Adult, Analysis of Variance, Body Height, Body Weight, Corticotropin-Releasing Hormone, Cosyntropin, Female, Hip, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Obesity, Pituitary-Adrenal System, Regression Analysis, Time Factors

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The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution

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