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Cited by 69Diabetes Management and ResearchPancreatic function and diabetesDiabetes and associated disorders

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Gender-Related Differences in Counterregulatory Responses to Antecedent Hypoglycemia in Normal Humans1

Davis, S. N., Shavers, C., Costa, F.·2000·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.85.6.6641
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Abstract

Compared to men, inherent counterregulatory responses are reduced in healthy and type 1 diabetic women. Despite this, the prevalence of hypoglycemia in patients with type 1 diabetes (type 1 DM) is gender neutral. The aim of this study was to determine the in vivo mechanism(s) responsible for this apparent clinical paradox. The central importance of antecedent hypoglycemia in causing subsequent counterregulatory failure is now established. We, therefore, hypothesized that a gender-related difference to the blunting effects of prior hypoglycemia may exist, and this could explain why type 1 DM women do not have an increased prevalence of hypoglycemia despite reduced counterregulatory responses. Fifteen healthy male and female individuals (eight men and seven women) underwent four separate 2-day experimental protocols in a randomized fashion. Day 1 involved identical morning and afternoon 2-h hyperinsulinemic (9 pmol/kg x min) glucose clamp studies with 5.1 +/- 0.1, 3.9 +/- 0.1, 3.3 +/- 0.1, or 2.9 +/- 0.1 mmol/L. Day 2 consisted of a single 2-h hypoglycemic clamp of 2.9 +/- 0.1 mmol/L. Insulin levels were similar on both days of each protocol in men and women. After day 1 euglycemia (5.1 +/- 0.1 mmol/L), day 2 counterregulatory responses were significantly increased (P < 0.01) in men relative to women. In women, counterregulatory responses were resistant to the effects of day 1 hypoglycemia. Antecedent hypoglycemia of 3.9, 3.3, and 2.9 +/- 0.1 mmol/L produced 3 +/- 2%, 5 +/- 2%,…

Overview

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Crossref · 10.1210/jcem.85.6.6641

Cites

48 of 48 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 2

  1. Davis, 1993, Effects of insulin on the counterregulatory responses to equivalent hypoglycemia in normal females, Am J Physiol., 265, E680
  2. DeFeo, 1983, The adrenergic contribution to glucose counterregulation in type I diabetes mellitus., Diabetes, 32, 887, 10.2337/diabetes.32.10.887 · DOI

Cited by

See all 69

Metadata

Authors
Davis, S. N., Shavers, C., & Costa, F.
Affiliations
Vanderbilt University (US)
ORCID
Davis, S. N.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2000-06-01
Volume
85
Issue
6
Pages
2148-2157
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.85.6.6641
OpenAlex
W1973205654
Cited by
69
References
48
Citations by year
2025: 4 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 5
FWCI
2.67
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Vanderbilt University
  • National Institutes of Health (5r01dk045369-05, 3p60am020593-07s1)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK 45369)
  • National Center for Research Resources (M01-RR-0095, M01RR000095)
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords
sex differences, type 1 diabetes, hypoglycemia, hyperinsulinemic-euglycemic clamp, hypoglycemic clamp, muscle sympathetic nerve activity, insulin secretion, glucose metabolism, hypoglycemia prevalence
MeSH terms
Activity Cycles, Adult, Blood Glucose, Diabetes Mellitus, Type 1, Epinephrine, Female, Glucagon, Hormones, Humans, Hydrocortisone, Hyperinsulinism, Hypoglycemia, Infusions, Intravenous, Insulin, Male, Norepinephrine, Pancreatic Polypeptide, Peroneal Nerve, Reference Values, Sex Characteristics, Sympathetic Nervous System, Glucose Clamp Technique, Muscle, Skeletal, Human Growth Hormone

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.