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Cited by 54Adrenal and Paraganglionic TumorsBone health and osteoporosis researchAdrenal Hormones and Disorders

The patients with incidentally discovered adrenal adenoma (incidentaloma) are not at increased risk of osteoporosis

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Osella, G., Reimondo, G., Peretti, P., Alì, A., Paccotti, P., Angeli, A., Terzolo, M.·2001·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.86.2.7178
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Abstract

The main problem in the management of the patients with incidentally discovered adrenal mass (incidentaloma) is whether and when the incidental mass puts the patient at increased risk for an adverse outcome. As osteoporosis is a well known complication of endogenous and exogenous glucocorticoid excess, it is likely that patients with incidentally discovered adrenocortical adenomas have impaired bone mass due to subclinical hypercortisolism. We measured spinal bone mineral density (BMD) by dual energy x-ray absorptiometry in 27 patients (9 men and 18 women) and 54 healthy subjects (18 men and 36 women) carefully matched for age, sex, body mass index, and menstrual status for a case-control analysis. BMD was also measured at the hip in the group of patients. A multiple regression analysis was performed to determine which biochemical variables might influence BMD values. Lumbar BMD values in patients with adrenal incidentaloma were not significantly different from those in control subjects (BMD, 0.926, 0.604--1.144 vs. 0.936, 0.645--1.268 g/cm(2); P = NS). No significant difference in lumbar and femoral BMD was found between patients with or without subclinical Cushing's syndrome. Among the variables processed, only PTH remained in the final model and was inversely correlated with lumbar spine and femoral neck BMD values (r = -0.5; r(2) = 0.25; P = 0.015 and r = -0.42; r(2) = 0.18; P = 0.03, respectively). In conclusion, our data do not suggest that the slight glucocorticoid excess associated with adrenal incidentaloma increases the risk of osteoporosis. The evaluation of BMD does not seem to be crucial in the management of incidentally discovered adrenal masses.

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  • Both trabecular and cortical bone loss have been described in patients with ACS.

    “Both trabecular (65,261-263) and cortical (259,262,264-266) bone loss have been described in patients with ACS.”

    From Adrenal incidentaloma (2020) · cites this paper as [263]

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Authors
Osella, G., Reimondo, G., Peretti, P., Alì, A., Paccotti, P., Angeli, A., & Terzolo, M.
Affiliations
  • Ospedale San Luigi Gonzaga (IT)
  • University of Turin (IT)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2001-02
Volume
86
Issue
2
Pages
604-607
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.86.2.7178
OpenAlex
W2151267942
Cited by
54
References
35
Citations by year
2025: 3 · 2024: 2 · 2023: 1 · 2021: 3 · 2020: 2 · 2018: 1 · 2016: 1 · 2014: 2 · 2012: 6
FWCI
5.20
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • INFM-OAR (INFN Catania) (submittedVersion, other-oa)
  • Zenodo (CERN European Organization for Nuclear Research) (other-oa)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
adrenal incidentaloma, adrenal adenoma, osteoporosis, bone mineral density, subclinical Cushing's syndrome, glucocorticoid excess, parathyroid hormone, lumbar spine, femoral neck
MeSH terms
Adenoma, Adrenal Gland Neoplasms, Adrenocorticotropic Hormone, Adult, Aged, Female, Follow-Up Studies, Humans, Hydrocortisone, Lumbar Vertebrae, Male, Middle Aged, Osteoporosis, Reference Values, Regression Analysis, Risk Factors, Spinal Cord, Absorptiometry, Photon, Bone Density, Case-Control Studies

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