ApoB48-Lipoproteins Are Associated with Cardiometabolic Risk in Adolescents with and without Polycystic Ovary Syndrome
Open accessAbstract
Context: Adolescents with polycystic ovary syndrome (PCOS) have increased incidence of cardiometabolic risk factors including dyslipidemia. Atherogenic apolipoprotein (apo) B-lipoprotein remnants are associated with increased cardiovascular disease (CVD) risk. Objective: The aim of this study was to determine the concentrations of fasting plasma apoB-lipoprotein remnants, apoB48 and apoB100, and their association with cardiometabolic risk factors and androgen indices in adolescent girls with and without PCOS. Design, setting and participants: Participants (n = 184) aged 17 years were recruited in the Menstruation in Teenagers Study from the Western Australian Pregnancy Cohort (Raine) Study. The main outcome measures: Fasting plasma apo-B48 and -B100 lipoprotein remnant concentrations in adolescent girls with and without PCOS. Results: Fasting plasma apoB48-lipoprotein remnants but not apoB100-lipoprotein remnants were elevated in adolescent girls with increased cardiometabolic risk compared with those with lower cardiometabolic risk (13.91 ± 5.06 vs 12.09 ± 4.47 µg/mL, P < .01). ApoB48-lipoprotein remnants were positively correlated with fasting plasma triglycerides (b = .43, P < .0001). The prevalence of increased cardiometabolic risk factors was 2-fold higher in those diagnosed with PCOS (35.3%) than in those without PCOS (16.3%).Conclusion: Adolescents with PCOS have a 2-fold higher incidence of cardiometabolic risk factors than those without PCOS. Fasting apoB48-lipoprotein remnants are elevated in adolescent girls with a high prevalence of cardiometabolic risk factors.
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Those with PCOS have a more adverse fasting lipid profile, positively associated with hyperandrogenemia, independent of obesity.
“We and others have reported that those with PCOS have a more adverse fasting lipid profile, and this is positively associated with hyperandrogenemia, independent of obesity.73, 74, 75,77, 78, 79”
From Increased Prevalence of Adverse Health Outcomes Across the Lifespan in Those Affected by Polycystic Ovary Syndrome: A Canadian Population Cohort (2024) · cites this paper as [77]
In Results, §B (page unavailable), this study reports no significant difference in fasting lipids between adolescents with and without PCOS, and no association between fasting apoB-lipoprotein remnants and androgen markers. The Discussion mentions positive associations reported in earlier studies, but explicitly says they were not found in the present cohort. The cited paper therefore does not support the claim for its own findings, including the asserted independence from obesity. (LLM, conf=0.88)
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“,77-79 Atherogenic dyslipidemia in the fasted and non-fasted state has been described in those with PCOS and commonly includes elevated plasma triglycerides, apoB-lipoproteins, remnant cholesterol and lowered high-density lipoprotein cholesterol, and impairments in postprandial clearance of…”
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- Authors
- Vine, D. F., Beilin, L. J., Burrows, S., Huang, R.-C., Hickey, M., Hart, R., Proctor, S. D., & Mori, T. A.
- Affiliations
- University of Alberta (CA)
- The University of Western Australia (AU)
- The Kids Research Institute Australia (AU)
- Royal Women's Hospital (AU)
- Corresponding author
- Vine, Donna F
- ORCID
- Venue
- Journal of the Endocrine Society
- Publisher
- The Endocrine Society
- Published
- 2020-05-26
- Volume
- 4
- Issue
- 8
- Pages
- bvaa061-bvaa061
- ISSN
- 2472-1972 (ISSN-L)
- PMC
- PMC7417872
- OpenAlex
- W3032147690
- Cited by
- 17
- References
- 55
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 1 · 2023: 6 · 2021: 3
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of the Endocrine Society (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-nd)
- UWA Profiles and Research Repository (UWA) (submittedVersion, cc-by-nc-nd)
- Funders
- University of Western Australia
- Telethon Kids Institute
- Raine Medical Research Foundation
- UWA Faculty of Medicine, Dentistry and Health Sciences
- Women’s and Infant’s Research Foundation
- Curtin University
- National Health and Medical Research Council (35351417, 403981, 1136046, APP 1058935)
- Heart and Stroke Foundation of Canada
- Alberta Livestock and Meat Agency
- Canadian Institute of Health Research
- Women and Children's Health Research Institute
- Alberta Diabetes Institute
- University of Alberta McCalla Professorship
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- polycystic ovary syndrome, apolipoprotein B-48, apolipoprotein B-100, remnant lipoproteins, cardiometabolic risk, adolescents, dyslipidemia, triglycerides, cardiovascular risk
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