Cited by 105Bone Metabolism and DiseasesFibroblast Growth Factor ResearchThyroid Disorders and Treatments

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Thyroid Hormone Activates Fibroblast Growth Factor Receptor-1 in Bone

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Stevens, David A., Harvey, Clare B., Scott, Anthea J., O’Shea, Patrick J., Barnard, Joanna C., Williams, Allan J., Brady, Gerard, Samarut, Jacques, Chassande, Olivier, Williams, Graham R.·2003·Molecular Endocrinology

DOI 10.1210/me.2003-0137

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Abstract

Thyroid hormone (T3) and the T3 receptor (TR) alpha gene are essential for bone development whereas adult hyperthyroidism increases the risk of osteoporotic fracture. We isolated fibroblast growth factor receptor-1 (FGFR1) as a T3-target gene in osteoblasts by subtraction hybridization. FGFR1 mRNA was induced 2- to 3-fold in osteoblasts treated with T3 for 6-48 h, and FGFR1 protein was stimulated 2- to 4-fold. Induction of FGFR1 was independent of mRNA half-life and abolished by actinomycin D and cycloheximide, indicating the involvement of an intermediary protein. Fibroblast growth factor 2 (FGF2) stimulated MAPK in osteoblasts, and pretreatment with T3 for 6 h induced a more rapid response to FGF that was increased in magnitude by 2- to 3-fold. Similarly, T3 enhanced FGF2-activated autophosphorylation of FGFR1, but did not modify FGF2-induced phosphorylation of the docking protein FRS2. These effects were abolished by the FGFR-selective inhibitors PD166866 and PD161570. In situ hybridization analyses of TRalpha-knockout mice, which have impaired ossification and skeletal mineralization, revealed reduced FGFR1 mRNA expression in osteoblasts and osteocytes, whereas T3 failed to stimulate FGFR1 mRNA or enhance FGF2-activated MAPK signaling in TRalpha-null osteoblasts. These findings implicate FGFR1 signaling in T3-dependent bone development and the pathogenesis of skeletal disorders resulting from thyroid disease.

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Authors: Stevens, D. A., Harvey, C. B., Scott, A. J., O’Shea, P. J., Barnard, J. C., Williams, A. J., Brady, G., Samarut, J., Chassande, O., & Williams, G. R.
Affiliations: Hammersmith Hospital (GB)
Imperial College London (GB)
University of Manchester (GB)
École Normale Supérieure de Lyon (FR)
Corresponding author: Williams, Graham R.
ORCID: Brady, Gerard
Williams, Graham R.
Venue: Molecular Endocrinology
Publisher: The Endocrine Society
Published: 2003-09
Volume: 17
Issue: 9
Pages: 1751-1766
ISSN: 0888-8809 (ISSN-L)
1944-9917
DOI: 10.1210/me.2003-0137
OpenAlex: W1964583412
Cited by: 105
References: 57
Citations by year: 2026: 2 · 2025: 5 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 7 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 8 · 2013: 7 · 2012: 8
FWCI: 1.49
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Molecular Endocrinology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Wellcome Trust (050570)
Nuffield Foundation
Medical Research Council (G9803002)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Keywords: thyroid hormones, FGFR1, FGFR1 signaling, FGF2, MAPK signaling, osteoblasts, osteocytes, skeletal development, thyroid dysfunction, osteoporosis, skeletal mineralization, FRS2
MeSH terms: Animals, Bone and Bones, Osteoblasts, Phosphorylation, Phosphotransferases, Pyrimidines, Thyroid Gland, Triiodothyronine, Urea, Signal Transduction, Fibroblast Growth Factor 2, Receptors, Fibroblast Growth Factor, Receptor Protein-Tyrosine Kinases, Mitogen-Activated Protein Kinases, Mice, Receptor, Fibroblast Growth Factor, Type 1

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Thyroid Hormone Activates Fibroblast Growth Factor Receptor-1 in Bone

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