Cited by 294Multiple Sclerosis Research StudiesTreatment of Major DepressionTryptophan and brain disorders

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Structural brain abnormalities in multiple sclerosis patients with major depression

Feinstein, A., Roy, P., Lobaugh, N., Feinstein, K., O’Connor, P., Black, S.·2004·Neurology

DOI 10.1212/01.wnl.0000110316.12086.0c

Open this paper in CoChat — free account

Abstract

Objective To assess the association between major depression and structural brain abnormalities in patients with multiple sclerosis (MS). Methods Two groups of patients with clinically definite MS were studied: 21 with Diagnostic and Statistical Manual of Mental Disorders (4th ed.)-defined major depression and 19 without. The groups did not differ on demographic, disease, or cognitive measures. All subjects underwent brain MRI. Tissue segmentation and regional brain masking were applied to the MRI data. Results Compared with the euthymic subjects, those with major depression had a greater T2-weighted lesion volume (p = 0.003) and more extensive T1-weighted lesion volume in the left medial inferior prefrontal cortex (p = 0.01) and less gray matter volume (p = 0.01) and more CSF volume in the left anterior temporal region (p = 0.005). A logistic regression analysis identified two independent predictors of depression: left medial inferior prefrontal cortex T2 lesion volume and left anterior temporal CSF volume. These variables accounted for 42% of the depression variance score. Conclusion Whereas both lesion burden and atrophy are important in the pathogenesis of depression in MS, psychosocial influences should also be considered.

Integrity signals

Registry

Crossref · 10.1212/01.wnl.0000110316.12086.0c

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139
Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
Kurtzke, J. F. (1983) · Neurology · doi:10.1212/wnl.33.11.1444 · Cited by 15,011
Paced Auditory Serial-Addition Task: A Measure of Recovery from Concussion
Gronwall, D. M. A. (1977) · Perceptual and Motor Skills · doi:10.2466/pms.1977.44.2.367 · Cited by 2,395
Selective hypometabolism in the inferior frontal lobe in depressed patients with Parkinson's disease
Mayberg, H. S., Starkstein, S. E., Sadzot, B., Preziosi, T., Andrezejewski, P. L., Dannals, R. F., Wagner, H. N., & Robinson, R. G. (1990) · Annals of Neurology · doi:10.1002/ana.410280111 · Cited by 412

Show all 4 references

Research works printed but not linked: 38

10.1001/archneur.1990.00530010124031 · DOI
Feinstein A. The clinical Neuropsychiatry of multiple sclerosis. New York: Cambridge University Press 1999.
10.1212/WNL.39.2.161 · DOI
10.1001/archneur.1987.00520140053017 · DOI
10.1136/jnnp.55.10.869 · DOI
10.1111/j.1600-0404.1992.tb05100.x · DOI
10.1017/S0033291700005602 · DOI
10.1212/WNL.49.4.1105 · DOI · Paper page
Bakshi R, Czarnecki D, Shaikh ZA, Priore R, Janardhan V, Kaliszky Z. Brain MRI lesions and atrophy are related to depression in multiple sclerosis. Brain Imag. 2000; 11: 1153–1158.
10.1001/archneur.55.1.66 · DOI
Mohr DC, Cox D, Epstein L, Goldberg A. Brain lesion and neuropsychological function predict efficacy of treatment for depression in multiple sclerosis. Psychosom Med. 2002; 64: 130.
10.1002/ana.410130302 · DOI · Paper page
First MB Spitzer RL Gibbon M Williams JBW. Structured Clinical Interview for Axis 1 DSM-IV Disorders—patient edition (SCID-I/P version 2.0). New York: Biometrics Research Department New York State Psychiatric Institute 1994. · DOI · Paper page
10.1002/ana.410360106 · DOI
10.1177/135245850000600509 · DOI
10.1212/WNL.41.5.685 · DOI
Benton AL Hamsher K de S. Multilingual Aphasia Examination. Iowa City: University of Iowa Press 1976.
10.1212/WNL.24.11.1019 · DOI
Barbizet J, Cany E. Clinical and psychometrical study of a patient with memory disturbances. Int J Neurol. 1968; 7: 44–54.
10.1006/nimg.2002.1221 · DOI
10.1006/nimg.2000.0649 · DOI
Talairach J Tournoux P. Co-planar stereotaxic atlas of the human brain. New York: Thieme Medical 1988.
10.1093/brain/122.1.17 · DOI · Paper page
Losseff NA, Wang L, Lai HM, et al. Progressive cerebral atrophy in multiple sclerosis. A serial study. Brain. 1996; 119: 2009–2019.
10.1212/WNL.42.9.1791 · DOI
10.1192/bjp.154.2.195 · DOI
10.1093/brain/107.1.81 · DOI
10.1016/S0140-6736(00)02448-X · DOI
10.1001/archneur.1993.00540080076020 · DOI · Paper page
Mayberg HS. Neuroimaging studies of depression in neurological disease. In: Starkstein SE Robinson RG eds. Depression in neurological disease. Baltimore: John Hopkins University Press 1993: 186–216.
10.1176/jnp.6.4.428 · DOI
10.1016/S0165-0327(00)00298-6 · DOI
10.1177/135245859700300408 · DOI
10.1177/135245850100700611 · DOI
10.1093/arclin/17.2.103 · DOI
10.1002/1097-4679(198407)40:4<1028::AID-JCLP2270400427>3.0.CO;2-1 · DOI
10.1177/135245850100700405 · DOI · Paper page
10.1177/135245850000600210 · DOI

Sorted by citations

Items 101–200 of 253

The role of sleep on cognition and functional connectivity in patients with multiple sclerosis
van Geest, Q., Westerik, B., van der Werf, Y. D., Geurts, J. J. G., & Hulst, H. E. (2016) · Journal of Neurology · doi:10.1007/s00415-016-8318-6 · Cited by 41
Correspondence among gray matter atrophy and atlas-based neurotransmitter maps is clinically relevant in multiple sclerosis
Fiore, A., Preziosa, P., Tedone, N., Margoni, M., Vizzino, C., Mistri, D., Gueye, M., Rocca, M. A., & Filippi, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01943-1 · Cited by 46
The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and comorbid substance use disorders
Beaulieu, S., Saury, S., Sareen, J., Tremblay, J., Schütz, C. G., McIntyre, R. S., & Schaffer, A. (2012) · Annals of Clinical Psychiatry · doi:10.1177/104012371202400105 · Cited by 38
Insights into the Pathophysiology of Psychiatric Symptoms in Central Nervous System Disorders: Implications for Early and Differential Diagnosis
Menculini, G., Chipi, E., Paoletti, F. P., Gaetani, L., Nigro, P., Simoni, S., Mancini, A., Tambasco, N., Filippo, M. D., Tortorella, A. A. V., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094440 · Cited by 44
Episodic memory and regional atrophy in frontotemporal lobar degeneration.
Söderlund, H., Black, S., Miller, B., Freedman, M., & Levine, B. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.08.003 · Cited by 38
Self-citation
Fatigue and depression predict health-related quality of life in patients with pediatric-onset multiple sclerosis.
Gravesande, K. S. V., Blaschek, A., Calabrese, P., Rostásy, K., Huppke, P., Josef Kessler, J., Kalbe, E., & Mall, V. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.08.010 · Cited by 37
A longitudinal study on fatigue, depression, and their relation to neurocognition in multiple sclerosis
Hildebrandt, H., & Eling, P. (2014) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2014.903900 · Cited by 34
Individual differences in depression are associated with abnormal function of the limbic system in multiple sclerosis patients
Riccelli, R., Passamonti, L., Cerasa, A., Nigro, S., Cavalli, S. M., Chiriaco, C., Valentino, P., Nisticò, R., & Quattrone, A. (2016) · Multiple Sclerosis · doi:10.1177/1352458515606987 · Cited by 36
One question as a screening instrument for depression in people with multiple sclerosis
Vahter, L., Kreegipuu, M., Talvik, T., & Gross-Paju, K. (2007) · Clinical Rehabilitation · doi:10.1177/0269215507074056 · Cited by 36
Predictors of emotional distress in people with multiple sclerosis: A systematic review of prospective studies
Fisher, P., Salmon, P., Heffer-Rahn, P., Huntley, C., Reilly, J., & Cherry, M. G. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.07.073 · Cited by 42
Clinical characteristics of cortical multiple sclerosis.
Zarei, M. (2006) · Journal of Neurological Sciences · doi:10.1016/j.jns.2005.08.025 · Cited by 35
“For example, a recent study showed that left medial inferior prefrontal cortex T2 lesion volume is an independent predictor for depression in multiple sclerosis [29].”
Result
Depression and fatigue in multiple sclerosis: Relation to exposure to violence and cerebrospinal fluid immunomarkers
Brenner, P., Granqvist, M., Königsson, J., Nimer, F. A., Piehl, F., & Jokinen, J. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.01.002 · Cited by 34
“At least part of the underlying variance in this association seems to be explained not by psychosocial factors or coping with disability, but by MS disease activity in itself (Feinstein et al., 2004).”
Influence of Personality on the Relationship Between Gray Matter Volume and Neuropsychiatric Symptoms in Multiple Sclerosis
Benedict, R., Schwartz, C., Duberstein, P., Healy, B., Hoogs, M., Bergsland, N., Dwyer, M., Weinstock-Guttman, B., & Zivadinov, R. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31828837cc · Cited by 33
“However, major depression may have some correlation with white matter andGMpathology in paralimbic regions of the brain inMS (29).”
Background
Cognitive predictors of response to treatment for depression in multiple sclerosis.
Julian, L., & Mohr, D. (2006) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.2006.18.3.356 · Cited by 33
Measuring life quality, physical function and psychological well-being in neurological illness
O’Doherty, L., Hickey, A., & Hardiman, O. M. (2010) · Amyotrophic Lateral Sclerosis · doi:10.3109/17482960903552488 · Cited by 28
Multiple Sclerosis and Demyelinating Diseases
Leary, S. M., Giovannoni, G., Howard, R. S., Miller, D. H., & Thompson, A. J. (2007) · doi:10.1002/9781444311709.ch10 · Cited by 32
“There have been two small, single-center studies (eight patients and four patients, respectively) that have shown that treatment with IFN β-1a (152) and treatment with IFN β-1b and intravenous methylprednisolone (153) favorably improves the recovery of MTR values in Gd-enhancing lesions.”
BackgroundResultInfluential
Neuropsychiatric syndromes associated with multiple sclerosis
Feinstein, A. (2007) · Journal of Neurology · doi:10.1007/s00415-007-2017-2 · Cited by 31
“Twenty-one patients with MS and major depression were matched to 19 MS non-depressed patients on all relevant demographic, neurological and psychosocial (cognitive status, social supports and stressors) variables before all subjects underwent detailed MRI [11].”
MethodSelf-citation
A Combined Radiomics and Machine Learning Approach to Overcome the Clinicoradiologic Paradox in Multiple Sclerosis
Pontillo, G., Tommasin, S., Cuocolo, R., Petracca, M., Petsas, N., Ugga, L., Carotenuto, A., Pozzilli, C., Iodice, R., Lanzillo, R., et al. (2021) · American Journal of Neuroradiology · doi:10.3174/ajnr.a7274 · Cited by 31
Anxiety and depressive symptoms in clinically isolated syndrome and multiple sclerosis.
Anhoque, C., Domingues, S. C. A., Carvalho, T., Teixeira, A., & Domingues, R. (2011) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2011000700006 · Cited by 31
A complex relation between depression and multiple sclerosis: a descriptive review
Corallo, F., Buono, V. L., Genovese, R., Palmeri, R., Cara, M. D., Rifici, C., Sessa, E., D’Aleo, G., Galletti, F., Bonanno, L., et al. (2019) · Neurological Sciences · doi:10.1007/s10072-019-03889-1 · Cited by 31
Psychiatric disturbances in radiologically isolated syndrome
Labiano-Fontcuberta, A., Aladro, Y., Martínez-Ginés, M. L., Ayuso, L., Mitchell, A. J., Puertas‐Martín, V., García, M. C., Higueras, Y., & Benito‐León, J. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.05.008 · Cited by 33
Impact of depression, fatigue and disability on quality of life in Chinese patients with multiple sclerosis.
Chen, K.-L., Fan, Y.-P., Hu, R., Yang, T., & Li, K.-N. (2013) · Stress and Health · doi:10.1002/smi.2432 · Cited by 30
Mood and anxiety disorders in patients with multiple sclerosis
Uğuz, F., Akpınar, Z., Özkan, İ., & Tokgoz, S. (2008) · International journal of psychiatry in clinical practice · doi:10.1080/13651500701330825 · Cited by 30
“[39] reported more hyperintense lesions in the left anterior medial frontal regions and greater atrophy of the left anterior temporal regions in depressed patients with MS compared to nondepressed patients with MS.”
Result
Depression, Anxiety, and Stress Relative to Swallowing Impairment in Persons with Multiple Sclerosis
Sadeghi, Z., Ghoreishi, Z., Flowers, H., Mohammadkhani, P., Ashtari, F., & Noroozi, M. (2021) · Dysphagia (New York. Print) · doi:10.1007/s00455-020-10207-x · Cited by 29
Physical comorbidities increase the risk of psychiatric comorbidity in multiple sclerosis
Marrie, R., Patten, S., Greenfield, J., Svenson, L., Jetté, N., Tremlett, H., Wolfson, C., Warren, S., Profetto-McGrath, J., Fisk, J., et al. (2016) · Brain and Behavior · doi:10.1002/brb3.493 · Cited by 29
“We considered psychiatric disorders as comorbidities, but arguably these conditions may be considered as symptoms or complications in some cases, given their association with structural changes in the brain (Feinstein et al. 2004).”
Background
Recognizing and Treating Common Psychiatric Disorders in Multiple Sclerosis
Wilken, J. A., & Sullivan, C. L. (2007) · The Neurologist · doi:10.1097/nrl.0b013e31806dc2e8 · Cited by 23
Fatigue and Affective Manifestations in Multiple Sclerosis—A Cluster Approach
Ayache, S., & Chalah, M. A. (2019) · Brain Science · doi:10.3390/brainsci10010010 · Cited by 28
Biological outcome measurements for behavioral interventions in multiple sclerosis
Fischer, A., Heesen, C., & Gold, S. M. (2011) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285611405252 · Cited by 23
“Some studies using magnetic resonance imaging (MRI) have reported associations of MS depression with lesion load in frontal, parietal, or temporal areas [Feinstein et al. 2004; Zorzon et al., Bakshi et al. 2000a].”
Depression, cardiac mortality and all-cause mortality
Seymour, J., & Benning, T. B. (2009) · Advances in Psychiatric Treatment · doi:10.1192/apt.bp.107.004770 · Cited by 30
Neuroimaging and Neuropathological Studies of Mood Disorders
Drevets, W. C., & Price, J. L. (2005) · Biology of Depression · doi:10.1002/9783527619672.ch17 · Cited by 26
Patterns and predictors of naturally occurring change in depressive symptoms over a 30-month period in multiple sclerosis
Ensari, I., Motl, R., McAuley, E., Mullen, S., & Feinstein, A. (2014) · Multiple Sclerosis · doi:10.1177/1352458513504251 · Cited by 24
Self-citation
Depression and neurological disorders
Benedetti, F., Bernasconi, A., & Pontiggia, A. (2005) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000194147.88647.7f · Cited by 45
Psychiatric symptoms in multiple sclerosis: a biological perspective on synaptic and network dysfunction
Menculini, G., Mancini, A., Gaetani, L., Bellingacci, L., Tortorella, A., Parnetti, L., & Filippo, M. D. (2023) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2022-329806 · Cited by 22
Imaging and depression in multiple sclerosis: a historical perspective
Masuccio, F. G., Gamberini, G., Calabrese, M., & Solaro, C. M. (2021) · Neurological Sciences · doi:10.1007/s10072-020-04951-z · Cited by 24
“T1W lesions 3 studies [15, 22, 31] correlated T1W lesions in frontal lobes with depression or depressive symptoms.”
BackgroundMethodInfluential
Gray and normal-appearing white matter in multiple sclerosis: an MRI perspective
Vrenken, H., & Geurts, J. J. G. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.3.271 · Cited by 23
Multiple sclerosis: treating symptoms, and other general medical issues.
Goldman, M., Cohen, J. A., Fox, R., & Bethoux, F. (2006) · Cleveland Clinic journal of medicine · doi:10.3949/ccjm.73.2.177 · Cited by 22
Mapping the Relationship of White Matter Lesions to Depression in Multiple Sclerosis
Baller, E. B., Sweeney, E. M., Cieslak, M., Robert‐Fitzgerald, T., Covitz, S. C., Martin, M. L., Schindler, M. K., Bar‐Or, A., Elahi, A., Larsen, B., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.11.010 · Cited by 36
“Given the high resolution necessary for segmentation, prior work often relied on research scans, increasing costs and effort for recruitment (50,51).”
Morphostructural MRI Abnormalities Related to Neuropsychiatric Disorders Associated to Multiple Sclerosis
Bonavita, S., Tedeschi, G., & Gallo, A. (2013) · Multiple Sclerosis International · doi:10.1155/2013/102454 · Cited by 21
“[13] evaluated MS subjects with and without depression by MRI; automatic tissue segmentation (grey matter (GM), WM, and cerebrospinal fluid (CSF)) and regional brain masking were applied to MRI data; regional and total LL were also calculated.”
Method
Psychiatric manifestations of autoimmune disorders
Weiss, D., Dyrud, J., House, R., & Beresford, T. (2005) · Current Treatment Options in Neurology · doi:10.1007/s11940-005-0033-z · Cited by 21
Symptom Interconnectivity in Multiple Sclerosis: A Narrative Review of Potential Underlying Biological Disease Processes
Chitnis, T., Vandercappellen, J., King, M., & Brichetto, G. (2022) · Neurology and Therapy · doi:10.1007/s40120-022-00368-2 · Cited by 19
Magnitude and concurrence of anxiety and depression among attendees with multiple sclerosis at a tertiary care Hospital in Oman
Al-Asmi, A., Al-Rawahi, S., Al-Moqbali, Z. S., Al-Farsi, Y., Essa, M., El-Bouri, M., Koshy, R. P., Gujjar, A., Jacob, P., Al-Hodar, A., et al. (2015) · BMC Neurology · doi:10.1186/s12883-015-0370-9 · Cited by 20
Depression in Multiple Sclerosis: Reactive or Endogenous?
Holden, K. E., & Isaac, C. (2011) · Clinical Neuropsychologist · doi:10.1080/13854046.2011.564208 · Cited by 20
Neuropsychiatric Manifestations of Multiple Sclerosis: (Rounds in the General Hospital)
Politte, L. C., Huffman, J. C., & Stern, T. A. (2008) · The Primary Care Companion to The Journal of Clinical Psychiatry · doi:10.4088/pcc.v10n0408 · Cited by 20
“Major depressive disorder in MS patients has been associated with characteristic CNS changes, including cortical atrophy and lesions in specific regions of the frontal lobes, which may account for some of this observed difference.(19) Major depressive disorder in patients with MS, therefore, is unlikely to represent a…”
Mapping the relationship of white matter lesions to depression in multiple sclerosis
Baller, E. B., Sweeney, E., Cieslak, M., Robert-Fitzgerald, T., Covitz, S., Martin, M., Schindler, M., Bar-Or, A., Elahi, A., Larsen, B., et al. (2023) · medRxiv · doi:10.1101/2023.06.09.23291080 · Cited by 19
“Given the high resolution necessary for segmentation, prior work often relied on research scans, increasing costs and effort for recruitment 43,44 .”
Deep gray matter substructure volumes and depressive symptoms in a large multiple sclerosis cohort
Hu, C., Dewey, B. E., Mowry, E. M., & Fitzgerald, K. C. (2023) · Multiple Sclerosis Journal · doi:10.1177/13524585221148144 · Cited by 21
Difference in fatigue and pain between neuromyelitis optica spectrum disorder and multiple sclerosis
Masuda, H., Mori, M., Uzawa, A., Uchida, T., Ohtani, R., & Kuwabara, S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0224419 · Cited by 19
“Another study reported that MS patients with major depression had a greater lesion volume compared to those without depression [29].”
Result
The associations between self-reported depression, self-reported chronic inflammatory conditions and cognitive abilities in UK Biobank
Lyall, L. M., Cullen, B., Lyall, D. M., Leighton, S., Siebert, S., Smıth, D. J., & Cavanagh, J. (2019) · European Psychiatry · doi:10.1016/j.eurpsy.2019.05.007 · Cited by 18
“One study found that multiple sclerosis (MS) patients with and without depressiondidnot differontestsofverbalfluency, attentionorverbal memory [13], while a recent systematic review found that depression in addition to diabetes was associated with reduced cognitive performance relative to diabetes without depression […”
Background
The prevalence of bipolar disorders and association with quality of life in a cohort of patients with multiple sclerosis
Jun-O’connell, A., Butala, A., Morales, I., Henninger, N., Deligiannidis, K., Byatt, N., & Ionete, C. (2016) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.15120403 · Cited by 19
“Low mood among MS patients has also been associated with structural and functional brain abnormalities, suggesting that depression in MS may arise directly from the demyelination process and be of a different etiology than depression in non-MS patients.(40,41) For example, a diffusion tensor imaging study demonstrated…”
The emotional disorders associated with multiple sclerosis
Raimo, S., Santangelo, G., & Trojano, L. (2021) · Handbook of clinical neurology · doi:10.1016/b978-0-12-822290-4.00009-8 · Cited by 20
Lesion Expansion in Experimental Demyelination Animal Models and Multiple Sclerosis Lesions
Große-Veldmann, R., Becker, B., Amor, S., van der Valk, P., Beyer, C., & Kipp, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9420-y · Cited by 18
Radiologically isolated syndrome: An update on a rare entity
Labiano-Fontcuberta, A., & Benito‐León, J. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458516653666 · Cited by 23
Pain and cognition in multiple sclerosis.
Benson, C. A., & Kerr, B. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_309 · Cited by 18
Patient-reported outcome parameters and disability worsening in progressive multiple sclerosis
Abdelhak, A., Antweiler, K., Kowarik, M. C., Şenel, M., Havla, J. B., Zettl, U. K., Kleiter, I., Hoshi, M., Skripuletz, T., Haarmann, A., et al. (2023) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2023.105139 · Cited by 20
Neuro-immune crosstalk in depressive symptoms of multiple sclerosis
Wang, C., Zhou, Y., & Feinstein, A. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106005 · Cited by 20
Self-citation
Computerized Cognitive Behavioral Therapy for Treatment of Depression in Multiple Sclerosis
Ratajska, A. M., Zurawski, J. D., Healy, B. C., & Glanz, B. I. (2018) · International Journal of MS Care · doi:10.7224/1537-2073.2017-094 · Cited by 16
Progressive multiple sclerosis and mood disorders
Lorefice, L., Fenu, G., Trincas, G., Moro, M. F., Frau, J., Coghe, G., Cocco, E. E., Marrosu, M. G., & Carta, M. G. (2015) · Neurological Sciences · doi:10.1007/s10072-015-2220-3 · Cited by 21
“The hypothesis that MDD is sustained by a specific neurodegenerative component is supported by some studies that linked MDD in MS to CNS damage mainly involving the frontotemporal regions [54, 55].”
Background
Neuroanatomy of pseudobulbar affect
Ghaffar, O., Chamelian, L., & Feinstein, A. (2008) · Journal of Neurology · doi:10.1007/s00415-008-0685-1 · Cited by 16
Self-citation
Impaired Neurovisceral Integration of Cardiovascular Modulation Contributes to Multiple Sclerosis Morbidities
Sternberg, Z. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9599-y · Cited by 15
Update on depression in neurologic illness: Stroke, epilepsy, and multiple sclerosis
Sobel, R. M., Lotkowski, S., & Mandel, S. M. (2005) · Current Psychiatry Reports · doi:10.1007/s11920-005-0043-2 · Cited by 15
Advances in neuropsychiatry: clinical implications
Dilley, M., & Fleminger, S. (2006) · Advances in Psychiatric Treatment · doi:10.1192/apt.12.1.23 · Cited by 15
“The most robust findings in depression implicate more hyperintense lesions in left inferior medial frontal regions and greater atrophy of left anterior temporal regions (Feinstein et al, 2004).”
Background
Multiple Sclerosis Patients in Saudi Arabia: Prevalence of Depression and its Extent of Severity
Alhussain, H. A., Aldayel, A. A., AlEnazi, A. S., & Alowain, F. (2020) · Cureus · doi:10.7759/cureus.7005 · Cited by 14
“Some early studies have shown that radiologically hyperintense lesions in prefrontal and temporal cortical regions lead to structural changes responsible for depression among MS patients [24].”
Effect of vitamin D replacement on depression in multiple sclerosis patients
Kotb, M. A., Kamal, A. M., Aldossary, N. M., & Bedewi, M. A. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.01.029 · Cited by 15
Relationship Between Global Cognitive Decline and Depressive Symptoms in Multiple Sclerosis
Barwick, F. H., & Arnett, P. A. (2011) · The Clinical Neuropsychologist · doi:10.1080/13854046.2010.538435 · Cited by 14
Multiple sclerosis and personality traits: associations with depression and anxiety
Vaheb, S., Mokary, Y., Panah, M. Y., Shaygannejad, A., Afshari-Safavi, A., Ghasemi, M., Shaygannejad, V., Ghaffary, E. M., & Mirmosayyeb, O. (2024) · European journal of medical research · doi:10.1186/s40001-024-01772-0 · Cited by 19
“Previous studies have demonstrated a notable connection between brain atrophy and affective disorders in pwMS, particularly major depression [39].”
Background
Emotional Change-Associated T Cell Mobilization at the Early Stage of a Mouse Model of Multiple Sclerosis
Piras, G., Rattazzi, L., McDermott, A., Deacon, R. M. J., & D’Acquisto, F. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00400 · Cited by 12
Psychische Störungen bei somatischen Krankheiten
Kapfhammer, H. P. (2011) · Springer eBooks · doi:10.1007/978-3-642-03637-8_76 · Cited by 7
Association between limbic system lesions and anxiety in persons with multiple sclerosis.
Hillyer, A., Sharma, M., Kuurstra, A., Rosehart, H., Menon, R., & Morrow, S. (2023) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2023.105021 · Cited by 12
Comorbidity effect on processing speed test and MRI measures in multiple sclerosis patients.
Abbatemarco, J. R., Ontaneda, D., Nakamura, K., Husak, S., Wang, Z., Alshehri, E., Bermel, R., & Conway, D. S. (2020) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2020.102593 · Cited by 12
Depression is associated with disconnection of neurotransmitter-related nuclei in multiple sclerosis
Martino, M., Magioncalda, P., Mendili, M. E. E., Droby, A., Paduri, S., Schiavi, S., Petracca, M., & Inglese, M. (2020) · Multiple Sclerosis · doi:10.1177/1352458520948214 · Cited by 12
Neuroimaging and neuromodulation of invisible symptoms in multiple sclerosis
Ayache, S., & Chalah, M. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2024.1376095 · Cited by 11
Utilizing the ICF to understand depressive symptomology in multiple sclerosis: An exploratory systematic review.
Dorstyn, D., Black, R., Mpofu, E., & Kneebone, I. (2017) · Rehabilitation Psychology · doi:10.1037/rep0000125 · Cited by 13
“This includes evidence from studies on neuropathological (i.e., atrophy, lesion volume) and immunological factors in depression (Feinstein et al., 2004).”
Background
Regional Specificity of Magnetization Transfer Imaging in Multiple Sclerosis
Tjoa, C., Benedict, R., Dwyer, M., Carone, D., & Zivadinov, R. (2008) · Journal of Neuroimaging · doi:10.1111/j.1552-6569.2007.00198.x · Cited by 11
Detecting Cognitive Dysfunction in Multiple Sclerosis with a Magnetic Resonance Imaging Rating Scale: A Pilot Study
Chamelian, L., Bocti, C., Gao, F.-Q., Black, S., & Feinstein, A. (2005) · CNS Spectrums · doi:10.1017/s1092852900022768 · Cited by 11
Self-citation
Mood Symptoms and Chronic Fatigue Syndrome Due to Relapsing-Remitting Multiple Sclerosis Are Associated with Immune Activation and Aberrations in the Erythron
Almulla, A., Jaleel, A. K. A., Algon, A. A. A., Tunvirachaisakul, C., Hassoun, H., Al-hakeim, H., & Maes, M. (2022) · medRxiv · doi:10.3390/brainsci13071073 · Cited by 10
“Activated immune-inflammatory pathways and consequent aberrations in brain structure and functions may render MS patients prone to develop mood symptoms and chronic fatigue syndrome [16,73,86].”
Background
Depression in multiple sclerosis.
Mrabet, S., Ali, N. B., Kchaou, M., & Belal, S. (2014) · Revue neurologique (Paris) · doi:10.1016/j.neurol.2014.07.017 · Cited by 10
Depression, anxiety and stress severities in multiple sclerosis patients using injectable versus oral treatments.
Al-Hussain, F., Al-Salloum, N., Alazwary, N., Saeedi, J., Howaidi, S., & Daif, A. (2017) · Journal of Comparative Effectiveness Research · doi:10.2217/cer-2016-0087 · Cited by 9
Disability in a Community Population with MS with and without Mental Disorders
Patten, S., Williams, J. V. A., Lavorato, D. H., Metz, L., & Bulloch, A. (2012) · International Journal of Psychiatry in Medicine · doi:10.2190/pm.43.1.d · Cited by 9
“MS lesions account for a proportion of the association between MS and major depression [16].”
Background
Sonographic basal ganglia alterations are related to non-motor symptoms in multiple sclerosis
Horowski, S., Zettl, U. K., Benecke, R., & Walter, U. (2010) · Journal of Neurology · doi:10.1007/s00415-010-5707-0 · Cited by 9
Psychotic Depression: A Peculiar Presentation for Multiple Sclerosis
Ağan, K., Günal, D. İ., Afşar, N., Tuncer, N., & Kuşçu, K. (2009) · International Journal of Neuroscience · doi:10.1080/00207450903139739 · Cited by 9
“…in the temporal lobe (Zorzon et al., 2001), arcuate fascicule in the dominant hemisphere (Pujol, Bello, Deus, Martı́-Vilalta, & Capdevila, 1997) frontal especially the medial inferior prefrontal cortex, parietal and dominant hemisphere temporal lobe (Feinstein et al., 2004) are claimed areas.”
Background
Cognitive Reserve Moderates the Effects of Fatigue and Depressive Symptoms in Multiple Sclerosis
Bradson, M. L., Cadden, M. H., Riegler, K. E., Thomas, G. A., Randolph, J. J., & Arnett, P. A. (2023) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acad041 · Cited by 9
A review on multiple sclerosis prognostic findings from imaging, inflammation, and mental health studies
Brasanac, J., & Chien, C. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1151531 · Cited by 7
“, 2014), and larger cerebral T2 lesion load (Feinstein et al., 2004).”
Background
Quantitative spinal cord MRI and sexual dysfunction in multiple sclerosis
Seyman, E., Kim, D. D., Bharatha, A., Casserly, C. S., Krysko, K. M., Roy-Hewitson, C., Leon, P. A., Suthiphosuwan, S., & Oh, J. (2022) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/20552173221132170 · Cited by 8
Neuropsychological and psychiatric aspects of multiple sclerosis: preliminary investigation of discrete profiles across neurological subtypes
Katsari, M., Kasselimis, D., Gasparinatos, G., Antonellou, R., & Voumvourakis, K. (2016) · Neurological Sciences · doi:10.1007/s10072-015-2463-z · Cited by 7
“It has also been shown that the burden of demyelinating lesions is related with the severity of depression [28].”
Background
The roles of fatigue, depression, and Big Five Personality traits in males with and without multiple sclerosis disease
Khodarahimi, S., & Rasti, A. (2015) · Clínica y Salud · doi:10.1016/j.clysa.2015.03.002 · Cited by 6
Coping in Neurological Disorders
Rabinowitz, A. R., & Arnett, P. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6605-5_2 · Cited by 7
“Evidence supporting neurobiological antecedents of depression can be found in the stroke, dementia, MS, and PD literatures (Feinstein et al., 2004 ; Remy, Doder, Lees, Turjanski, & Brooks, 2005 ; Schweitzer, Tuckwell, O’Brien, & Ames, 2002 ; Singh et al., 2000 ).”
Background
Personality traits in people with multiple sclerosis: A systematic review and meta-analysis
Mirmosayyeb, O., Panah, M. Y., Vaheb, S., Shaygannejad, V., & Balconi, J. (2025) · The Clinical Neuropsychologist · doi:10.1080/13854046.2025.2508476 · Cited by 6
“…regions) and lower levels of Conscientiousness – these brain structural alternations are associated with mood disorders like major depression (Feinstein et al., 2004; Fuchs, Jaworski, et al., 2022; Fuchs, Schoonheim, et al., 2022; Fuchs, Vaughn, et al., 2022; Schaefer et al., 2012; Vaheb et…”
Posterior Fossa Lesion Load and Pathological Laughing and Crying in Multiple Sclerosis.
Luhoway, J., Sharma, M., Menon, S., Rosehart, H., & Morrow, S. (2019) · International Journal of MS Care · doi:10.7224/1537-2073.2018-016 · Cited by 6
Preventing suicidal behavior in patients with multiple sclerosis: a scoping review
Mellentin, A., Stenager, E., & Stenager, E. (2018) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2018.1549990 · Cited by 6
Impairment of Visual Cognition in Progressive Multiple Sclerosis
Bak, T. H., & Chandran, S. (2014) · Journal of Multiple Sclerosis · doi:10.4172/2376-0389-1000129 · Cited by 3
“Regional atrophy imaging studies of MS patients with and without depression have reported conflicting results, however frontal and temporal lobe pathology appear as the most consistent associations [30–32].”
Result
Multipl Skleroz Hastalarinda Umutsuzluk, Depresyon Ve Yaşam Doyumu
Aşiret, G. D., Özdemir, L., & Maraşlıoğlu, N. (2014) · Turkish Journal Of Neurology · doi:10.4274/tnd.24471 · Cited by 6
Functional neurological disorder in multiple sclerosis: A prospective study
Cuoco, S., Scannapieco, S., Barra, F., Giordano, C., Gregorio, M. D., Barone, P., & Erro, R. (2025) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2025.106264 · Cited by 5
Depressive Symptoms and Suicidal Ideation in Progressive Multiple Sclerosis Compared With Relapsing-Remitting Multiple Sclerosis: Results From a Cross-sectional Survey
Knowles, L. M., Esselman, E. C., Turner, A. P., Phillips, K. M., Herring, T. E., Alschuler, K. N., & Ehde, D. M. (2020) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2020.09.385 · Cited by 8
Effects of the Anti-Multiple Sclerosis Immunomodulator Laquinimod on Anxiety and Depression in Rodent Behavioral Models
Gil-Ad, I., Amit, B. H., Hayardeni, L., Tarasenko, I., Taler, M., Gueta, R. U., & Weizman, A. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0387-3 · Cited by 5
Depression and Other Psychosocial Issues in Multiple Sclerosis
Rintell, D. J. (2012) · Wiley eBooks · doi:10.1002/9781119963714.ch11 · Cited by 3
Patients with Neurologic Conditions II. Movement Disorders, Multiple Sclerosis, and Other Neurologic Conditions
Roffman, J. L. (2004) · Elsevier eBooks · doi:10.1016/b978-0-323-02767-0.50032-2 · Cited by 3
Risk Factors for Psychiatric Disorders in Patients with Multiple Sclerosis—A Single-Center Study in the Polish Population
Mado, H., Błachut, M. K., Szczegielniak, A. R., Świerzy, K., Zając, M., Kubicka, K., Gorczyca, P. W., & Adamczyk-Sowa, M. H. (2024) · Medicina · doi:10.3390/medicina60030376 · Cited by 3
“Korostil and Feinstein [45,46] evaluated 140 patients using the SCID-I questionnaire to diagnose anxiety disorders.”
BackgroundMethod
Neuropathological features of “non‐motor” symptoms in multiple sclerosis and neuromyelitis optica
Kawachi, I. (2019) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12533 · Cited by 3
“The exact pathomechanisms of cognitive impairment in NMOSD have also remained unclear.13 However, pathological studies have provided a few key pathomechanisms of cognitive impairment as follows: (i) neuronal loss in cortical layers II, III and IV; (ii) AQP4 loss in astrocytes in layer I; (iii) increased activation of…”
BackgroundInfluential
Diffusion Tensor Imaging‐Defined Sulcal Enlargement Is Related to Cognitive Impairment in Multiple Sclerosis
Keser, Z., Hasan, K. M., Mwangi, B., Gabr, R., & Nelson, F. M. (2017) · Journal of Neuroimaging · doi:10.1111/jon.12406 · Cited by 4
A Comparison between Anxious-Depressive Disorders of Stroke and Multiple Sclerosis Patients, Evaluated with Specific Twin Scales
Gainotti, G., Quaranta, D., & Marra, C. (2016) · Journal of Traumatic Stress Disorders & Treatment · doi:10.4172/2324-8947.1000157 · Cited by 4
“Therefore, even if the occurrence of depression has often been associated to neuronal damage in the left frontal lobe in post-stroke depression [7,21-24] and to lesions in frontal and temporal lobes in depressed MS patients [25,26], several papers have stressed the psychological nature of variables predicting depressi…”
Background
Correlations between depression, cognitive status, functional scores, disability and lesion load in multiple sclerosis treated with interferon beta 1a
Maier, S., Bălașa, R., Bajko, Z., Maier, A., Șchiopu, B., & Buruian, M. (2015) · Acta Marisiensis. Seria Medica · doi:10.1515/amma-2015-0016 · Cited by 4
“concluded that the burden of demyelinating lesions was associated with the severity of depression [44]; we found that the level of depression correlated significantly with the number of T2 lesions on an MRI scan.”
Background

Authors: Feinstein, A., Roy, P., Lobaugh, N., Feinstein, K., O’Connor, P., & Black, S.
Affiliations: St. Michael's Hospital (CA)
From the University of Toronto (Drs. Feinstein, Lobaugh, O’Connor, and Black), Sunnybrook and Women’s College Health Sciences Centre (Drs. Feinstein, Lobaugh, and Black, P. Roy), and St. Michael’s Hospital (Dr. O’Connor, K. Feinstein), Toronto, Ontario, Canada.
ORCID: Feinstein, A.
Lobaugh, N.
Black, S.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-02-24
Volume: 62
Issue: 4
Pages: 586-590
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000110316.12086.0c
OpenAlex: W2149802110
Cited by: 294
References: 34
Citations by year: 2026: 6 · 2025: 5 · 2024: 7 · 2023: 12 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 13 · 2018: 13 · 2017: 9 · 2016: 13 · 2015: 20 · 2014: 16 · 2013: 14 · 2012: 15
FWCI: 12.52
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: multiple sclerosis, major depressive disorder, structural brain abnormalities, gray matter atrophy, cerebrospinal fluid volume, anterior temporal lobe, brain MRI, lesion burden, depression pathogenesis
MeSH terms: Adult, Atrophy, Brain, Cognition Disorders, Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Structural brain abnormalities in multiple sclerosis patients with major depression

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks