Cited by 294Multiple Sclerosis Research StudiesTreatment of Major DepressionTryptophan and brain disorders

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Structural brain abnormalities in multiple sclerosis patients with major depression

Feinstein, A., Roy, P., Lobaugh, N., Feinstein, K., O’Connor, P., Black, S.·2004·Neurology

DOI 10.1212/01.wnl.0000110316.12086.0c

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Abstract

Objective To assess the association between major depression and structural brain abnormalities in patients with multiple sclerosis (MS). Methods Two groups of patients with clinically definite MS were studied: 21 with Diagnostic and Statistical Manual of Mental Disorders (4th ed.)-defined major depression and 19 without. The groups did not differ on demographic, disease, or cognitive measures. All subjects underwent brain MRI. Tissue segmentation and regional brain masking were applied to the MRI data. Results Compared with the euthymic subjects, those with major depression had a greater T2-weighted lesion volume (p = 0.003) and more extensive T1-weighted lesion volume in the left medial inferior prefrontal cortex (p = 0.01) and less gray matter volume (p = 0.01) and more CSF volume in the left anterior temporal region (p = 0.005). A logistic regression analysis identified two independent predictors of depression: left medial inferior prefrontal cortex T2 lesion volume and left anterior temporal CSF volume. These variables accounted for 42% of the depression variance score. Conclusion Whereas both lesion burden and atrophy are important in the pathogenesis of depression in MS, psychosocial influences should also be considered.

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Authors: Feinstein, A., Roy, P., Lobaugh, N., Feinstein, K., O’Connor, P., & Black, S.
Affiliations: St. Michael's Hospital (CA)
From the University of Toronto (Drs. Feinstein, Lobaugh, O’Connor, and Black), Sunnybrook and Women’s College Health Sciences Centre (Drs. Feinstein, Lobaugh, and Black, P. Roy), and St. Michael’s Hospital (Dr. O’Connor, K. Feinstein), Toronto, Ontario, Canada.
ORCID: Feinstein, A.
Lobaugh, N.
Black, S.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-02-24
Volume: 62
Issue: 4
Pages: 586-590
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000110316.12086.0c
OpenAlex: W2149802110
Cited by: 294
References: 34
Citations by year: 2026: 6 · 2025: 5 · 2024: 7 · 2023: 12 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 13 · 2018: 13 · 2017: 9 · 2016: 13 · 2015: 20 · 2014: 16 · 2013: 14 · 2012: 15
FWCI: 12.52
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: multiple sclerosis, major depressive disorder, structural brain abnormalities, gray matter atrophy, cerebrospinal fluid volume, anterior temporal lobe, brain MRI, lesion burden, depression pathogenesis
MeSH terms: Adult, Atrophy, Brain, Cognition Disorders, Depressive Disorder, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis

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Structural brain abnormalities in multiple sclerosis patients with major depression

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