The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
An altered immune response to Epstein-Barr virus in multiple sclerosis: A prospective study
Abstract
OBJECTIVE: To investigate the association between human herpesviruses and multiple sclerosis (MS), as well as between measles virus and MS. METHODS: The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for Epstein-Barr virus (EBV [EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella zoster virus (VZV), and measles. RESULTS: All cases showed signs of past EBV infection. High activity to EBNA-1 and HHV-6 significantly (borderline significance for HHV-6) increased the risk for MS in prospective sera. A discrepancy between activities to EBNA-1 and VCA was striking in MS samples collected less than 5 years before relapsing-remitting MS onset, where high activity to EBNA-1 significantly increased, and high VCA activity significantly decreased the risk for MS. There was no support for major causal roles for HSV, VZV, or measles. CONCLUSION: Individuals who will develop MS exhibit an altered immune response against the EBV virus characterized by a high IgG activity to EBNA-1 in the absence of high activity to VCA, this being most pronounced in the 5-year period preceding MS onset.
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1 retracted
Multiple Sclerosis and Epstein-Barr Virus
Levin, L. I., Munger, K. L., Rubertone, M. V., Peck, C. A., Lennette, E. T., Spiegelman, D., & Ascherio, A. (2003) · JAMA · doi:10.1001/jama.289.12.1533 · Cited by 165
RetractedNew diagnostic criteria for multiple sclerosis: Guidelines for research protocols
Poser, C. M., Paty, D. W., Scheinberg, L., McDonald, W. I., Davis, F. A., Ebers, G. C., Johnson, K. P., Sibley, W. A., Silberberg, D. H., & Tourtellotte, W. W. (1983) · Annals of Neurology · doi:10.1002/ana.410130302 · Cited by 7,384
Defining the clinical course of multiple sclerosis: Results of an international survey
Lublin, F. D., Reingold, S. C., & National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis* (1996) · Neurology · doi:10.1212/wnl.46.4.907 · Cited by 3,686
Wucherpfennig, K. W., & Strominger, J. L. (1995) · Cell · doi:10.1016/0092-8674(95)90348-8 · Cited by 1,534
A functional and structural basis for TCR cross-reactivity in multiple sclerosis
Lang, H. L. E., Jacobsen, H., Ikemizu, S., Andersson, C., Harlos, K., Madsen, L., Hjorth, P., Sondergaard, L., Svejgaard, A., Wucherpfennig, K., et al. (2002) · Nature Immunology · doi:10.1038/ni835 · Cited by 591
Epstein-Barr Virus Antibodies and Risk of Multiple Sclerosis: A Prospective Study
Ascherio, A., Munger, K. L., Lennette, E. T., Spiegelman, D., Hernán, M. A., Olek, M. J., Hankinson, S. E., & Hunter, D. J. (2001) · JAMA · doi:10.1001/jama.286.24.3083 · Cited by 549
HISTOCOMPATIBILITY DETERMINANTS IN MULTIPLE SCLEROSIS, WITH SPECIAL REFERENCE TO CLINICAL COURSE
Jersild, C., Hansen, G., Svejgaard, A., Fog, T., Thomsen, M., & Dupont, B. (1973) · The Lancet · doi:10.1016/s0140-6736(73)90970-7 · Cited by 469
Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure
James, J. A., Neas, B. R., Moser, K. L., Hall, T., Bruner, G. R., Sestak, A. L., & Harley, J. B. (2001) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200105)44:5<1122::aid-anr193>3.0.co;2-d · Cited by 390
Synaptic plasticity and mood disorders
Duman, R. S. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001016 · Cited by 363
Evidence for genetic basis of multiple sclerosis
Sadovnick, A. D., the Canadian Collaborative Study Group, Dyment, D. A., Ebers, G. C., & Risch, N. J. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90807-7 · Cited by 351
Cited by
Multiple sclerosis: risk factors, prodromes, and potential causal pathways
Ramagopalan, S. V., Dobson, R., Meier, U. C., & Giovannoni, G. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70094-6 · Cited by 548
Levin, L. I. (2005) · JAMA · doi:10.1001/jama.293.20.2496 · Cited by 448
Should donors be allowed to give broad consent to future biobank research?
Hansson, M. G., Dillner, J., Bartram, C. R., Carlson, J. A., & Helgesson, G. (2006) · The Lancet Oncology · doi:10.1016/s1470-2045(06)70618-0 · Cited by 382
Self-citationB and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers
van Langelaar, J., Rijvers, L., Smolders, J., & van Luijn, M. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00760 · Cited by 319
DeLorenze, G. N., Munger, K. L., Lennette, E. T., Orentreich, N., Vogelman, J. H., & Ascherio, A. (2006) · Archives of Neurology · doi:10.1001/archneur.63.6.noc50328 · Cited by 257
Metadata
- Authors
- Sundström, P., Juto, P., Wadell, G., Hallmans, G., Svenningsson, A., Nyström, L., Dillner, J., & Forsgren, L.
- Venue
- Neurology
- Published
- 2004-06-22
- Volume
- 62
- Issue
- 12
- Pages
- 2277-2282
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1984168657
- Cited by
- 301
- References
- 25
- FWCI
- 8.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: An altered immune response to Epstein-Barr virus in multiple sclerosis: A prospective study. https://app.cochat.ai/papers/10.1212/01.wnl.0000130496.51156.d7
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- Sundström, P., Juto, P., Wadell, G., Hallmans, G., Svenningsson, A., Nyström, L., Dillner, J., & Forsgren, L. (2004). An altered immune response to Epstein-Barr virus in multiple sclerosis: A prospective study. Neurology. https://doi.org/10.1212/01.wnl.0000130496.51156.d7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
