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Cited by 256Nursing care and researchAmyotrophic Lateral Sclerosis ResearchFamily Caregiving in Mental Illness

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

A longitudinal study on quality of life and depression in ALS patient–caregiver couples

Gauthier, A., Vignola, A., Calvo, A., Cavallo, E., Moglia, C., Sellitti, L., Mutani, R., Chiò, A.·2007·Neurology
DOI 10.1212/01.wnl.0000257093.53430.a8
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Abstract

OBJECTIVES: To evaluate the modification of quality of life (QoL) and depression in a series of amyotrophic lateral sclerosis (ALS) patient-caregiver couples during a period of 9 months and compare them to patients' ALS Functional Rating Scale (ALS-FRS). METHODS: Depression was assessed with Zung Depression Scale (ZDS) and QoL with McGill Quality of Life Questionnaire (MQoL). Caregivers' burden was assessed with Caregiver Burden Inventory (CBI), and patients' feeling to be a burden with the Self-Perceived Burden Scale (SPBS). RESULTS: Thirty-one ALS patient-caregiver couples were interviewed at baseline and after 9 months. The mean ALS-FRS score was 28.7 (SD 7) at baseline and 24.1 (6.9) at the second interview (p = 0.0001). Patients' mean MQoL score slightly increased from 6.8 (1.6) to 7 (1.1) (p = 0.07); their ZDS score slightly increased (43.2 [8.7] at baseline and 45.7 [9.3] at the second interview) but they remained in the not depressed range. Caregivers' mean MQoL score slightly decreased, and their mean ZDS increased from 38.9 (8.1) to 42.2 (8.7) (p = 0.02). The mean CBI score increased from 50.3 (17.6) to 55.8 (16.4) (p = 0.03). CONCLUSIONS: We found a substantial steadiness of quality of life and depression in patients with amyotrophic lateral sclerosis over a 9-month period, vs a significant increase of burden and depression of their caregivers.

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Crossref · 10.1212/01.wnl.0000257093.53430.a8

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Research works printed but not linked: 3

  1. Bungener C, Piquard A, Pradat P-F, Salachas F, Meininger V, Lacomblez L. Psychopathology in amyotrophic lateral sclerosis: a preliminary study with 27 ALS patients. ALS 2005;6:221–225.
  2. Cohen SR, Mount BM, Strobel MG, Bui F. The McGill Quality of Life Questionnaire: a measure of quality of life appropriate for people with advanced disease. A preliminary study of validity and acceptability. Palliat Med 1995;9:207–219.
  3. Goldstein LH, Leigh PN. Motor neuron disease: a review of its emotional and cognitive consequences for patients and its impact on carers. Br J Health Psychol 1999;4:193–208.

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Metadata

Authors
Gauthier, A., Vignola, A., Calvo, A., Cavallo, E., Moglia, C., Sellitti, L., Mutani, R., & Chiò, A.
Affiliations
  • University of Turin (IT)
  • From the Department of Neuroscienze, University of Torino, Italy.
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-03-20
Volume
68
Issue
12
Pages
923-926
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/01.wnl.0000257093.53430.a8
OpenAlex
W2011506008
Cited by
256
References
27
Citations by year
2026: 1 · 2025: 10 · 2024: 10 · 2023: 23 · 2022: 9 · 2021: 16 · 2020: 11 · 2019: 10 · 2018: 13 · 2017: 14 · 2016: 14 · 2015: 19 · 2014: 17 · 2013: 13 · 2012: 17
FWCI
38.28
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Topics
  • Health Sciences › Nursing › Research and Theory › Nursing care and research
  • Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
  • Social Sciences › Psychology › Clinical Psychology › Family Caregiving in Mental Illness
Keywords
amyotrophic lateral sclerosis, quality of life, depression, caregiver burden, self-perceived burden, functional decline, longitudinal change
MeSH terms
Adaptation, Psychological, Aged, Amyotrophic Lateral Sclerosis, Attitude to Death, Depression, Disability Evaluation, Female, Humans, Longitudinal Studies, Male, Middle Aged, Quality of Life, Caregivers, Cost of Illness, Disease Progression

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