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Motor speech signature of behavioral variant frontotemporal dementia: Refining the phenotype
Open accessAbstract
OBJECTIVE: To provide a comprehensive description of motor speech function in behavioral variant frontotemporal dementia (bvFTD). METHODS: Forty-eight individuals (24 bvFTD and 24 age- and sex-matched healthy controls) provided speech samples. These varied in complexity and thus cognitive demand. Their language was assessed using the Progressive Aphasia Language Scale and verbal fluency tasks. Speech was analyzed perceptually to describe the nature of deficits and acoustically to quantify differences between patients with bvFTD and healthy controls. Cortical thickness and subcortical volume derived from MRI scans were correlated with speech outcomes in patients with bvFTD. RESULTS: Speech of affected individuals was significantly different from that of healthy controls. The speech signature of patients with bvFTD is characterized by a reduced rate (75%) and accuracy (65%) on alternating syllable production tasks, and prosodic deficits including reduced speech rate (45%), prolonged intervals (54%), and use of short phrases (41%). Groups differed on acoustic measures derived from the reading, unprepared monologue, and diadochokinetic tasks but not the days of the week or sustained vowel tasks. Variability of silence length was associated with cortical thickness of the inferior frontal gyrus and insula and speech rate with the precentral gyrus. CONCLUSIONS: One in 8 patients presented with moderate speech timing deficits with a further two-thirds rated as mild or subclinical. Subtle but measurable deficits in prosody are common in bvFTD and should be considered during disease management. Language function correlated with speech timing measures derived from the unprepared monologue only.
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Citations
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Fischl, B. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.021 · Cited by 9,526
Fischl, B., Salat, D. H., Busa, E., Albert, M., Dieterich, M., Haselgrove, C., van der Kouwe, A., Killiany, R., Kennedy, D., Klaveness, S., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00569-x · Cited by 8,610
Saliency, switching, attention and control: a network model of insula function
Menon, V., & Uddin, L. Q. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0262-0 · Cited by 5,592
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221
Classification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141
Where do you know what you know? The representation of semantic knowledge in the human brain
Patterson, K., Nestor, P. J., & Rogers, T. T. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2277 · Cited by 2,706
The anatomy of language: a review of 100 fMRI studies published in 2009
Price, C. J. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05444.x · Cited by 1,387
The prevalence of frontotemporal dementia
Ratnavalli, E., Brayne, C., Dawson, K. E., & Hodges, J. R. (2002) · Neurology · doi:10.1212/wnl.58.11.1615 · Cited by 1,182
The overlap of amyotrophic lateral sclerosis and frontotemporal dementia
Lomen, C. E., Anderson, T. T., & Miller, B. L. (2002) · Neurology · doi:10.1212/wnl.59.7.1077 · Cited by 699
Woolley, J. D., Khan, B. K., Murthy, N. K., Miller, B. L., & Rankin, K. P. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06382oli · Cited by 549
Connected speech production in three variants of primary progressive aphasia
Wilson, S. M., Henry, M. L., Besbris, M., Ogar, J. M., Dronkers, N. F., Jarrold, W., Miller, B. L., & Gorno-Tempini, M. L. (2010) · Brain · doi:10.1093/brain/awq129 · Cited by 546
Boeve, B. F., Lang, A. E., & Litvan, I. (2003) · Annals of Neurology · doi:10.1002/ana.10570 · Cited by 526
Behavioural-variant frontotemporal dementia: diagnosis, clinical staging, and management
Piguet, O., Hornberger, M., Mioshi, E., & Hodges, J. R. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70299-4 · Cited by 496
The frontotemporal dementia-motor neuron disease continuum
Burrell, J. R., Halliday, G. M., Kril, J. J., Ittner, L. M., Götz, J., Kiernan, M. C., & Hodges, J. R. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00737-6 · Cited by 384
Connected speech as a marker of disease progression in autopsy-proven Alzheimer’s disease
Ahmed, S., Haigh, A.-M. F., de Jager, C. A., & Garrard, P. (2013) · Brain · doi:10.1093/brain/awt269 · Cited by 362
The contribution of the insula to motor aspects of speech production: A review and a hypothesis
Ackermann, H., & Riecker, A. (2004) · Brain and Language · doi:10.1016/s0093-934x(03)00347-x · Cited by 343
Leyton, C. E., Villemagne, V. L., Savage, S. A., Pike, K. E., Ballard, K. J., Piguet, O., Burrell, J. R., Rowe, C. C., & Hodges, J. R. (2011) · Brain · doi:10.1093/brain/awr216 · Cited by 322
The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia
Kertesz, A., Martínez‐Lage, P., Davidson, W., & Muñoz, D. G. (2000) · Neurology · doi:10.1212/wnl.55.9.1368 · Cited by 306
Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia
Whitwell, J. L., Avula, R. T. V., Senjem, M. L., Kantarci, K., Weigand, S. D., Samikoglu, A. R., Edmonson, H. A., Vemuri, P., Knopman, D. S., Boeve, B. F., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d9edde · Cited by 256
Chare, L., Hodges, J. R., Leyton, C. E., McGinley, C., Tan, R. H., Kril, J. J., & Halliday, G. M. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-306948 · Cited by 249
Progressive Nonfluent Aphasia and Its Characteristic Motor Speech Deficits
Ogar, J. M., Dronkers, N. F., Brambati, S. M., Miller, B. L., & Gorno‐Tempini, M. L. (2007) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31815d19fe · Cited by 213
Functional network connectivity in the behavioral variant of frontotemporal dementia
Filippi, M., Agosta, F., Scola, E., Canu, E., Magnani, G., Marcone, A., Valsasina, P., Caso, F., Copetti, M., Comi, G., et al. (2013) · Cortex · doi:10.1016/j.cortex.2012.09.017 · Cited by 177
Meta-Analysis of fMRI Studies of Disruptive Behavior Disorders
Alegria, A. A., Radua, J., & Rubia, K. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.15081089 · Cited by 174
Damage to the anterior arcuate fasciculus predicts non-fluent speech production in aphasia
Fridriksson, J., Guo, D., Fillmore, P., Holland, A., & Rorden, C. (2013) · Brain · doi:10.1093/brain/awt267 · Cited by 172
Differentiating primary progressive aphasias in a brief sample of connected speech
Ash, S., Evans, E., O'Shea, J., Powers, J., Boller, A., Weinberg, D., Haley, J., McMillan, C., Irwin, D. J., Rascovsky, K., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e31829c5d0e · Cited by 171
Croot, K., Ballard, K. J., Leyton, C. E., & Hodges, J. R. (2012) · Journal of Speech Language and Hearing Research · doi:10.1044/1092-4388(2012/11-0323 · Cited by 156
Overlapping Networks Engaged during Spoken Language Production and Its Cognitive Control
Geranmayeh, F., Wise, R. J. S., Mehta, A., & Leech, R. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0428-14.2014 · Cited by 154
Non-fluent speech in frontotemporal lobar degeneration
Ash, S., Moore, P., Vesely, L., Gunawardena, D., McMillan, C. T., Anderson, C., Avants, B., & Grossman, M. (2009) · Journal of Neurolinguistics · doi:10.1016/j.jneuroling.2008.12.001 · Cited by 148
Patterns of longitudinal brain atrophy in the logopenic variant of primary progressive aphasia
Rohrer, J. D., Caso, F., Mahoney, C., Henry, M. L., Rosen, H. J., Rabinovici, G. D., Rossor, M. N., Miller, B. L., Warren, J. D., Fox, N. C., et al. (2013) · Brain and Language · doi:10.1016/j.bandl.2012.12.008 · Cited by 130
Profiles of white matter tract pathology in frontotemporal dementia
Mahoney, C. J., Ridgway, G. R., Malone, I. B., Downey, L. E., Beck, J., Kinnunen, K. M., Schmitz, N., Golden, H. L., Rohrer, J. D., Schott, J. M., et al. (2014) · Human Brain Mapping · doi:10.1002/hbm.22468 · Cited by 124
The Language Profile of Behavioral Variant Frontotemporal Dementia
Hardy, C. J. D., Buckley, A. H., Downey, L. E., Lehmann, M., Zimmerer, V. C., Varley, R. A., Crutch, S. J., Rohrer, J. D., Warrington, E. K., & Warren, J. D. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150806 · Cited by 122
Clinical diagnostic criteria and classification controversies in frontotemporal lobar degeneration
Rascovsky, K., & Grossman, M. (2013) · International Review of Psychiatry · doi:10.3109/09540261.2013.763341 · Cited by 110
Ballard, K. J., Savage, S., Leyton, C. E., Vogel, A. P., Hornberger, M., & Hodges, J. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089864 · Cited by 105
Self-citationPoole, M. L., Brodtmann, A., Darby, D., & Vogel, A. P. (2017) · Journal of Speech, Language, and Hearing Research · doi:10.1044/2016_jslhr-s-16-0140 · Cited by 84 · cited 2×
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Self-citationNeuroimaging comparison of primary progressive apraxia of speech and progressive supranuclear palsy
Whitwell, J. L., Duffy, J. R., Strand, E. A., Machulda, M. M., Senjem, M. L., Gunter, J. L., Kantarci, K., Eggers, S. D. Z., Jack, C. R., & Josephs, K. A. (2012) · European Journal of Neurology · doi:10.1111/ene.12004 · Cited by 60
Automatic method of pause measurement for normal and dysarthric speech
Rosen, K. M., Murdoch, B. E., Folker, J. E., Vogel, A. P., Cahill, L., Delatycki, M. B., & Corben, L. A. (2010) · Clinical Linguistics & Phonetics · doi:10.3109/02699200903440983 · Cited by 49
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Vogel, A. P., & Maruff, P. (2014) · Logopedics Phoniatrics Vocology · doi:10.3109/14015439.2013.775332 · Cited by 45
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Vogel, A. P., Fletcher, J. M., & Maruff, P. T. (2014) · Speech Communication · doi:10.1016/j.specom.2014.05.002 · Cited by 28
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Metadata
- Authors
- Vogel, A. P., Poole, M. L., Pemberton, H., Caverlé, M. W. J., Boonstra, F. M. C., Low, E., Darby, D., & Brodtmann, A.
- Affiliations
- Box Hill Hospital (AU)
- ORCID
- Venue
- Neurology
- Published
- 2017-08-22
- Volume
- 89
- Issue
- 8
- Pages
- 837-844
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2738539667
- Cited by
- 49
- References
- 41
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 4 · 2023: 8 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 4
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Health Professions › Speech and Hearing › Voice and Speech Disorders
- Keywords
- behavioral variant frontotemporal dementia, motor speech, prosody, speech rate, speech acoustics, cortical thickness, inferior frontal gyrus, insula, precentral gyrus, speech fluency, language functions
- MeSH terms
- Cerebral Cortex, Female, Humans, Lactose Tolerance Test, Magnetic Resonance Imaging, Male, Middle Aged, Motor Skills, Organ Size, Phenotype, Speech, Speech Production Measurement, Frontotemporal Dementia
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