Cited by 110Dementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis ResearchHistorical and Modern Theater Studies

Clinical diagnostic criteria and classification controversies in frontotemporal lobar degeneration

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Rascovsky, Katya, Grossman, Murray·2013·International Review of Psychiatry

Abstract

Frontotemporal lobar degeneration (FTLD) can manifest as a spectrum of clinical syndromes, ranging from behavioural impairment to language or motor dysfunction. Recently, revised diagnostic criteria have been proposed for the behavioural and progressive aphasia syndromes associated with frontotemporal degeneration. The present review will summarize these diagnostic guidelines and highlight some lingering controversies in the classification of FTLD clinical syndromes. We will discuss common tools and methods used to identify the insidious changes of behavioural variant frontotemporal dementia (bvFTD), the value of new, patient-based tasks of orbitofrontal function, and the issue of a benign or 'phenocopy' variant of bvFTD. With regard to primary progressive aphasia (PPA), we will discuss the scope of the semantic disorder in semantic-variant PPA, the nature of the speech disorder in non-fluent, agrammatic PPA, and the preliminary utility of a logopenic PPA classification.

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  1. Libon DJ Xie SX Moore P Farmer J Antani S McCawley G Grossman M 2007b Patterns of neuropsychological impairment in frontotemporal dementia Neurology 68 369 375 17261685

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Authors
Rascovsky, K., & Grossman, M.
Affiliations
University of Pennsylvania (US)
Corresponding author
Rascovsky, Katya
Venue
International Review of Psychiatry
Published
2013-04
Volume
25
Issue
2
Pages
145-158
ISSN
  • 0954-0261 (ISSN-L)
  • 1369-1627
OpenAlex
W2170424118
Cited by
110
References
152
Citations by year
2026: 7 · 2025: 9 · 2024: 11 · 2023: 11 · 2022: 11 · 2021: 10 · 2020: 3 · 2019: 4 · 2018: 8 · 2017: 13 · 2016: 8 · 2015: 12 · 2014: 3
FWCI
5.45
Type
journal article
Language
en
Open access
Locations
  • International Review of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (AG15116, AG-32953, R01AG015116, P01AG017586, AG17586, P01AG032953)
  • National Institute of Neurological Disorders and Stroke (NS53488, NS-44266, P50NS053488, R01NS044266)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
Keywords
frontotemporal lobar degeneration, diagnostic criteria, clinical classification, behavioral variant frontotemporal dementia, primary progressive aphasia, semantic variant PPA, phenocopy, behavioural impairment, language disorders
MeSH terms
Decision Making, Humans, Neuropsychological Tests, Social Adjustment, Aphasia, Primary Progressive, Executive Function, Theory of Mind, Emotional Intelligence, Frontotemporal Lobar Degeneration

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