Clinical diagnostic criteria and classification controversies in frontotemporal lobar degeneration
Open accessAbstract
Frontotemporal lobar degeneration (FTLD) can manifest as a spectrum of clinical syndromes, ranging from behavioural impairment to language or motor dysfunction. Recently, revised diagnostic criteria have been proposed for the behavioural and progressive aphasia syndromes associated with frontotemporal degeneration. The present review will summarize these diagnostic guidelines and highlight some lingering controversies in the classification of FTLD clinical syndromes. We will discuss common tools and methods used to identify the insidious changes of behavioural variant frontotemporal dementia (bvFTD), the value of new, patient-based tasks of orbitofrontal function, and the issue of a benign or 'phenocopy' variant of bvFTD. With regard to primary progressive aphasia (PPA), we will discuss the scope of the semantic disorder in semantic-variant PPA, the nature of the speech disorder in non-fluent, agrammatic PPA, and the preliminary utility of a logopenic PPA classification.
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Clinical diagnosis of the FTD variants was based on current criteria.
“Clinical diagnosis of the FTD variants was based on current criteria (Armstrong et al., 2013; Gorno-Tempini et al., 2011; Rascovsky & Grossman, 2013; Rascovsky et al., 2011).”
From Multiclass characterization of frontotemporal dementia variants via multimodal brain network computational inference (2023) · cites this paper as Rascovsky & Grossman, 2013
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Менделевич, Е. Г. (2024) · Neurology Bulletin · doi:10.17816/nb625675
- Authors
- Rascovsky, K., & Grossman, M.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Rascovsky, Katya
- ORCID
- Grossman, Murray
- Venue
- International Review of Psychiatry
- Publisher
- Informa UK Limited
- Published
- 2013-04
- Volume
- 25
- Issue
- 2
- Pages
- 145-158
- ISSN
- 0954-0261 (ISSN-L)
- 1369-1627
- PMC
- PMC3906583
- OpenAlex
- W2170424118
- Cited by
- 110
- References
- 152
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 11 · 2023: 11 · 2022: 11 · 2021: 10 · 2020: 3 · 2019: 4 · 2018: 8 · 2017: 13 · 2016: 8 · 2015: 12 · 2014: 3
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- International Review of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG15116, AG-32953, R01AG015116, P01AG017586, AG17586, P01AG032953)
- National Institute of Neurological Disorders and Stroke (NS53488, NS-44266, P50NS053488, R01NS044266)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- frontotemporal lobar degeneration, diagnostic criteria, clinical classification, behavioral variant frontotemporal dementia, primary progressive aphasia, semantic variant PPA, phenocopy, behavioural impairment, language disorders
- MeSH terms
- Decision Making, Humans, Neuropsychological Tests, Social Adjustment, Aphasia, Primary Progressive, Executive Function, Theory of Mind, Emotional Intelligence, Frontotemporal Lobar Degeneration
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