β-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia
Abstract
Objective To investigate whether global and regional beta-amyloid (Abeta) burden as measured with 11C Pittsburgh compound B (PIB) PET is associated with hippocampal atrophy characterized using MRI in healthy controls and patients with amnestic mild cognitive impairment (aMCI) or Alzheimer disease (AD). Methods Ninety-two elderly healthy controls, 32 subjects with aMCI, and 35 patients with AD were imaged using 11C-PIB PET and MRI. Hippocampal volume was measured and PIB standardized uptake value ratio was extracted after partial volume correction within 41 regions of interest. Global, regional, and voxel-based correlations between PIB and hippocampal volume were computed for each group. Results In healthy control participants with elevated neocortex PIB retention, significant correlation was found between PIB retention in the inferior temporal region and hippocampal volume using both region-based and voxel-based approaches. No correlation was found in any other group. Conclusions The strong correlation between hippocampal atrophy and beta-amyloid (Abeta) burden in the Pittsburgh compound B-positive healthy control group suggests that Abeta deposition in the inferior temporal neocortex is related to hippocampal synaptic and neuronal degeneration.
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Cognitive decline itself is poorly correlated with changes in amyloid burden.
“Furthermore, cognitive decline itself is poorly correlated with changes in amyloid burden”
From Alzheimer's Protection by <scp>PLCγ2</scp> Compacts Plaques, Redistributes Microglia, and Protects Synapses in <scp> <i>App</i> <sup> <i>NL</i> </sup> </scp> <sup> <i>‐G‐F</i> </sup> Mice (2026) · cites this paper as Bourgeat et al. 2010
Significant numbers of aged cognitively normal individuals exhibit some level of amyloid deposition.
“and significant numbers of aged cognitively normal individuals exhibit some level of amyloid deposition”
From Alzheimer's Protection by <scp>PLCγ2</scp> Compacts Plaques, Redistributes Microglia, and Protects Synapses in <scp> <i>App</i> <sup> <i>NL</i> </sup> </scp> <sup> <i>‐G‐F</i> </sup> Mice (2026) · cites this paper as Bourgeat et al. 2010
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- Authors
- Bourgeat, P., Chételat, G., Villemagne, V. L., Fripp, J., Raniga, P., Pike, K., Acosta, O., Szoeke, C., Ourselin, S., Ames, D., Ellis, K. A., Martins, R. N., Masters, C. L., Rowe, C. C., & Salvado, O.
- Affiliations
- Commonwealth Scientific and Industrial Research Organisation (AU)
- From the CSIRO Preventative Health National Research Flagship ICTC (P.B., J.F., P.R., O.A., C.S., O.S.), The Australian e-Health Research Centre-BioMedIA, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia; Department of Nuclear Medicine and Centre for PET (G.C., V.L.V., K.P., C.C.R.), Austin Health, Victoria, Australia; Inserm-EPHE-Université de Caen/Basse-Normandie (G.C.), Unité U923, GIP Cyceron, CHU Côte de Nacre, Caen, France; The Mental Health Research Institute (V.L.V., K...
- Edith Cowan University (AU)
- ORCID
- Venue
- Neurology
- Published
- 2010-01-12
- Volume
- 74
- Issue
- 2
- Pages
- 121-127
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2030847210
- Cited by
- 220
- References
- 5
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 9 · 2018: 13 · 2017: 20 · 2016: 11 · 2015: 18 · 2014: 18 · 2013: 32 · 2012: 21
- FWCI
- 22.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- HAL (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- amyloid-beta, Pittsburgh compound B, hippocampal atrophy, temporal neocortex, inferior temporal cortex, amyloid PET, hippocampal volume, amnestic mild cognitive impairment, Alzheimer's disease, synaptic degeneration
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Algorithms, Aniline Compounds, Atrophy, Brain Mapping, Carbon Radioisotopes, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Degeneration, Severity of Illness Index, Temporal Lobe, Thiazoles, Cohort Studies, Biomarkers, Amyloid beta-Peptides, Disease Progression, Neocortex, Positron-Emission Tomography, Plaque, Amyloid
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