CoChat
Sign Up
Cited by 112Gastrointestinal motility and disordersParkinson's Disease Mechanisms and TreatmentsPelvic floor disorders treatments

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Placebo-controlled trial of lubiprostone for constipation associated with Parkinson disease

Ondo, W.G., Kenney, C., Sullivan, K., Davidson, A., Hunter, C., Jahan, I., McCombs, A., Miller, A., Zesiewicz, T.A.·2012·Neurology
DOI 10.1212/wnl.0b013e3182574f28
Open this paper in CoChat — free account

Abstract

Objective To evaluate the efficacy and tolerability of lubiprostone (Amitiza) for constipation in Parkinson disease (PD) in a double-blind, randomized, controlled study. Methods Patients with PD and clinically meaningful constipation (constipation rating scale score > 10 [range: 0-28]) were recruited from 2 academic movement disorder centers to participate in the study. After enrollment, patients were initially followed for 2 weeks and then were randomly assigned 1:1 to lubiprostone, and the dose was titrated up to 48 μg/day. They returned 4 weeks later for a final assessment. Data included stool diaries and global impressions (co-primary endpoints), demographics, Unified Parkinson's Disease Rating Scale scores, constipation scale scores, visual analog scale (VAS) scores, a stool diary, and adverse events. Results Fifty-four subjects (39 male, mean age 67.0 ± 10.1 years, and mean duration of PD 8.3 ± 5.4 years) were randomly assigned to lubiprostone or placebo. One patient in the drug group discontinued the study because of logistics, and one patient in the placebo group discontinued the study because of lack of efficacy. A marked or very marked clinical global improvement was reported by 16 of 25 (64.0%) subjects receiving drug vs 5 of 27 (18.5%) subjects receiving placebo (p = 0.001). The constipation rating scale (p Conclusion In this randomized controlled trial, lubiprostone seemed to be well tolerated and effective for the short-term treatment of constipation in PD.

Overview

Integrity signals

Registry

Crossref · 10.1212/wnl.0b013e3182574f28

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 34 references

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Ondo, W. G., Kenney, C., Sullivan, K., Davidson, A., Hunter, C., Jahan, I., McCombs, A., Miller, A., & Zesiewicz, T. A.
Affiliations
Baylor College of Medicine (US)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-05-22
Volume
78
Issue
21
Pages
1650-1654
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0b013e3182574f28
OpenAlex
W2041741770
Cited by
112
References
34
Citations by year
2026: 3 · 2025: 13 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 8 · 2020: 11 · 2019: 12 · 2018: 4 · 2017: 4 · 2016: 12 · 2015: 8 · 2014: 3 · 2013: 9 · 2012: 2
FWCI
6.77
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Urology › Pelvic floor disorders treatments
Keywords
lubiprostone, Parkinson's disease, constipation, gastrointestinal motility, prokinetic agents, drug efficacy, drug tolerability, stool frequency, adverse events
MeSH terms
Lubiprostone, Aged, Alprostadil, Constipation, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Middle Aged, Parkinson Disease, Placebos, Severity of Illness Index, Vasodilator Agents, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review