Cited by 146Parkinson's Disease Mechanisms and TreatmentsNeurological disorders and treatmentsDementia and Cognitive Impairment Research

Clinical Criteria for the Diagnosis of Parkinson’s Disease

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Reichmann, Heinz·2010·Neurodegenerative Diseases

Abstract

The diagnosis of Parkinson’s disease (PD) follows the UK Brain Bank Criteria, which demands bradykinesia and one additional symptom, i.e. rigidity, resting tremor or postural instability. The latter is not a useful sign for the early diagnosis of PD, because it does not appear before Hoehn and Yahr stage 3. Early symptoms of PD which precede the onset of motor symptoms are hyposmia, REM sleep behavioral disorder, constipation, and depression. In addition, an increasing number of patients whose PD is related to a genetic defect are being described. Thus, genetic testing may eventually develop into a tool to identify at-risk patients. The clinical diagnosis of PD can be supported by levodopa or apomorphine tests. Imaging studies such as cranial CT or MRI are helpful to distinguish idiopathic PD from atypical or secondary PD. SPECT and PET methods are valuable to distinguish PD tremor from essential tremor if this is clinically not possible. Using all of these methods, we may soon be able to make a premotor diagnosis of PD, which will raise the question whether early treatment is possible and ethically and clinically advisable.

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  • Occasionally, tremor in Parkinson's disease involves the legs and other tremor types may occur.

    “Occasionally, the tremor involves the legs and other tremor types may occur (Reichmann 2010).”

    From The clinical symptoms of Parkinson's disease. (2016) · cites this paper as Reichmann 2010

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Research works printed but not linked: 6

  1. Findley LJ, Gresty MA: Tremor. Br J Hosp Med 1981; 26: 16-32.
  2. Clarimón J, Pagonabarraga J, Paisán-Ruiz C, et al: Tremor dominant parkinsonism: clini- cal description and LRRK2 mutation screen- ing. Mov Disord 2008; 15: 518-523.
  3. Weiner WJ, Nora LM, Glantz RH: Elderly in- patients: postural reflexes impairment. Neu- rology 1984; 34: 945-947.
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  5. Williams DR, Lees AJ: Progressive supranu- clear palsy: clinicopathological concepts of diagnostic challenges. Lancet Neurol 2009; 8: 270-279.
  6. Double KL, Rowe DB, Carew-Jones FM, et al: Anti-melanin antibodies are increased in sera in Parkinson's disease. Exp Neurol 2009; 217: 297-301.

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Authors
Reichmann, H.
Affiliations
University Hospital Carl Gustav Carus (DE)
Corresponding author
Reichmann, Heinz
Venue
Neurodegenerative Diseases
Publisher
S. Karger AG
Published
2010
Volume
7
Issue
5
Pages
284-290
ISSN
  • 1660-2854 (ISSN-L)
  • 1660-2862
OpenAlex
W2080778120
Cited by
145
References
60
Citations by year
2026: 9 · 2025: 6 · 2024: 18 · 2023: 7 · 2022: 11 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 9 · 2017: 11 · 2016: 12 · 2015: 9 · 2014: 7 · 2013: 10 · 2012: 7
FWCI
1.12
Type
journal article
Language
en
Open access
Locations
  • Neurodegenerative Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • Qucosa (Saxon State and University Library Dresden) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Parkinson's disease, diagnosis, bradykinesia, postural instability, REM sleep behavior disorder, hyposmia, constipation, depression, genetic testing, apomorphine test, SPECT, PET, essential tremor, atypical Parkinson's disease
MeSH terms
Diagnostic Imaging, Humans, Movement, Parkinson Disease, Point-of-Care Systems, Clinical Laboratory Techniques, Early Diagnosis

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