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Cited by 420Dementia and Cognitive Impairment ResearchAcute Ischemic Stroke ManagementNeurological Disease Mechanisms and Treatments

Dementia after stroke: Baseline frequency, risks, and clinical features in a hospitalized cohort

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Tatemichi, T. K., Desmond, D. W., Mayeux, R., Paik, M., Stern, Y., Sano, M., Remien, R. H., Williams, J.B.W. +3 more·1992·Neurology
DOI 10.1212/wnl.42.6.1185
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Abstract

We determined the frequency of dementia in a cohort of 251 patients aged greater than or equal to 60 years hospitalized with acute ischemic stroke, based on examinations performed 3 months after stroke onset. Using modified DSM-III-R criteria, we found dementia in 66 patients (26.3%). Diagnostic agreement among raters was excellent (kappa = 0.96). In a control sample of 249 stroke-free subjects recruited from the community and matched by age, we found dementia in eight subjects (3.2%). Using a logistic regression model to estimate the risk of dementia associated with stroke in the combined samples, the odds ratio (OR) for stroke patients compared with control subjects was 9.4 (p less than 0.001). Advancing age and fewer years of education were significant, independent correlates of dementia, with a trend evident for race (non-white versus white). Confining the analysis to subjects residing in the Washington Heights-Inwood community of northern Manhattan, the OR was 10.3 (p less than 0.001) with significant age and race effects. We conclude that ischemic stroke significantly increases the risk of dementia, with independent contributions by age, education, and race.

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  • Risk of new-onset dementia after stroke is approximately twice that of age- and sex-matched controls and averages about 10% after first stroke, depending on location, volume, severity, and early complications.

    “The risk of new-onset dementia after a stroke is approximately twice the rate for age- and sex-matched control subjects270 and averages ≈10% after the first stroke, depending on the location, volume of damaged brain tissue,30 clinical severity, and presence of early poststroke complications (seizure, delirium, hypoxia, hypotension).”

    From Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (2011) · cites this paper as [30]

    The citation is attached to the claim that new-onset dementia risk is approximately twice that of age- and sex-matched controls. The Results report an adjusted odds ratio of 9.4 for dementia after stroke versus stroke-free controls, and the methods say the groups differed by sex; the study assessed dementia three months after stroke rather than establishing new onset. The later ≈10% and complication claims are not attached to this citation. (LLM, conf=0.90)

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1 of the 43 references couldn’t be matched to a known paper.

Research works printed but not linked: 8

  1. Kase CS, Wolf PA, Bachman DL, Linn RT, Cupples LA. Dementia and stroke: the Framingham study. In: Ginsberg MD, Dietrich WD, eds. Cerebrovascular diseases. 16th Research (Princeton) Conference. New York: Raven Press, 1989:193-198.
  2. Katzman R, Lasker B, Bernstein N. Advances in the diagnosis' of dementia: accuracy of diagnosis and consequences of misdi- agnosis of disorders causing dementia. In: Terry RD, ed. Aging and the brain. New York Raven Press, 198817-62.
  3. Rosen W. The Rosen drawing test. Bronx, NY: Veterans 1968;114:797-811. 1992;49:453-460. 1974;24:1019-1025.
  4. Williams JBW. A structured interview guide for t h e Hamilton Depression Rating Scale. Arch Gen Psychiatry 1988;45:742-747.
  5. Tatemichi TK, Desmond DW, Paik M, et al. The mini-men- tal state examination as a screen for dementia following stroke [abstract]. J Clin Exp Neuropsychol 1991;13:419.
  6. Wade DT, Skilbeck C, Hewer RL. Selected cognitive losses after stroke. Int Disabil Stud 1989;11:34-39.
  7. Rosen WG, Terry RD, Fuld PA, Katzman R, Peck A. Pathologic verification of ischemic score differentiation of dementias. Ann Neurol 1979;7:486-488.
  8. Hijdra A, Derix MMA, Teunisse S , van Goo1 WA, Kwa IH. Dementia after stroke [letter]. Stroke 1991;22:416.

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Authors
Tatemichi, T. K., Desmond, D. W., Mayeux, R., Paik, M., Stern, Y., Sano, M., Remien, R. H., Williams, J. B. W., Mohr, J. P., Hauser, W. A., & Figueroa, M.
Affiliations
Columbia University (US)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1992-06
Volume
42
Issue
6
Pages
1185-1185
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.42.6.1185
OpenAlex
W2132851971
Cited by
420
References
43
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 33 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 13 · 2015: 8 · 2014: 8 · 2013: 16 · 2012: 16
FWCI
6.07
Type
journal article
Language
en
Open access
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Academy of Neurology
  • National Institutes of Health (7r01ns026179-11)
  • National Institute on Aging (P01AG007232)
  • National Institute of Mental Health (P30MH043520)
  • National Institute of Neurological Disorders and Stroke (R01 NS26179)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
dementia, ischemic stroke, post-stroke dementia, dementia risk factors, age, race, older adults
MeSH terms
Aged, Cerebrovascular Disorders, Dementia, Hospitalization, Humans, Middle Aged, Prospective Studies, Reference Values, Risk Factors, Statistics as Topic, Cohort Studies, Incidence

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