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Risk of Alzheimer's disease and duration of NSAID use
Open accessAbstract
In a longitudinal study of 1,686 participants in the Baltimore Longitudinal Study of Aging, we examined whether the risk of Alzheimer's disease (AD) was reduced among reported users of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). In addition, we examined use of acetaminophen, a pain-relief medication with little or no anti-inflammatory activity, to assess the specificity of the association between AD risk and self-reported medications. Information on use of medications was collected during each biennial examination between 1980 and 1995. The relative risk (RR) for AD decreased with increasing duration of NSAID use. Among those with 2 or more years of reported NSAID use, the RR was 0.40 (95% confidence interval [CI]: 0.19-0.84) compared with 0.65 (95% CI: 0.33-1.29) for those with less than 2 years of NSAID use. The overall RR for AD among aspirin users was 0.74 (95% CI: 0.46-1.18), and no trend of decreasing risk of AD was observed with increasing duration of aspirin use. No association was found between AD risk and use of acetaminophen (RR = 1.35; 95% CI: 0.79-2.30), and there was no trend of decreasing risk with increasing duration of use. These findings are consistent with evidence from cross-sectional studies indicating protection against AD risk among NSAID users and with evidence suggesting that one stage of the pathophysiology leading to AD is characterized by an inflammatory process.
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“The recognition that a robust inflammatory response contributes to AD also fuelled the discovery that long-term treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) reduced the risk for AD, delayed disease onset, and slowed cognitive decline (McGeer et al., 1996;Stewart et al., 1997;in t' in t'Veld et al., 2001).”
From PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice (2012) · cites this paper as Stewart et al., 1997
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Cites
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404
Kaplan, E., Goodglass, H., Weıntraub, S., & Segal, O. (2001) · Medical Entomology and Zoology · Cited by 4,378
Bayes Estimates for the Linear Model
Lindley, D. V., & Smith, A. F. M. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00885.x · Cited by 2,025
Normal Human Aging: The Baltimore Longitudinal Study on Aging
Shock, N. W., Greulich, R. C., Costa, P. T., Andres, R., Lakatta, E. G., Arenberg, D., & Tobin, J. D. (1984) · University Libraries (University of Maryland) · doi:10.13016/sclw-iccq · Cited by 757
Inverse association of anti‐inflammatory treatments and Alzheimer's disease
Breitner, J. C. S., Gau, B. A., Welsh-Bohmer, K. A., Plassman, B. L., McDonald, W. M., Helms, M. J., & Anthony, J. C. (1994) · Neurology · doi:10.1212/wnl.44.2.227 · Cited by 569
Activation of the classical complement pathway in brain tissue of Alzheimer patients
McGeer, P. L., Akiyama, H., Itagaki, S., & McGeer, E. G. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90843-4 · Cited by 383
Stremmel, W., Strohmeyer, G. W., Borchard, F., Kochwa, S., & Berk, P. D. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.1.4 · Cited by 350
A Population-Based Study of the Risk of Recurrence of Birth Defects
Lie, R. T., Wilcox, A. J., & Skjærven, R. (1994) · New England Journal of Medicine · doi:10.1056/nejm199407073310101 · Cited by 164
Cohler, B. J., ROBBINS, D. M., Hartman, C. R., Shader, R. I., Grunebaum, H. U., Gallant, D. H., & Weiss, J. L. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90017-5 · Cited by 132
The need for multiple time points in aging studies
Coleman, P. A., Finch, C. E., & Joseph, J. A. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90055-5 · Cited by 66
Research works printed but not linked: 16
- Altstiel L, Sperber K. Cytokines in Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry 1991;15:481-495.
- Eikelenboom P, Stam FC. Immunoglobulins and complement factors in senile plaques: an immunohistochemical study. Acta Neuropathol (Berl) 1982;57:239-252.
- Anonymous. The Canadian Study of Health and Aging: Risk factors for Alzheimer's disease in Canada. Neurology 1994;44:2073-2080.
- Lucca U, Tettamanti M, Forloni G, Spagnoli A. Nonsteroidal antiinflammatory drug use in Alzheimer's disease. Biol Psychiatry 1994;36:854-856.
- Andersen K, Launer LJ, Ott A, Hoes AW, Breteler MMB, Hofman A. Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease? Neurology 1995;45:1441-1445.
- Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile changes in the cerebral gray matter of elderly subjects. Br J Psychiatry 1968;114:797-811.
- Benton AL. Differential behavioral effects in frontal lobe disease. Neuropsychologia 1968;6:53-60.
- Rouleau I, Salmon DP, Butters N, Kennedy C, McGuire K. Quantitative and qualitative analyses of clock drawings in Alzheimer's and Huntington's disease. Brain Cogn 1992;18:70-87.
- Morris JC, Mohs R, Rogers H, Fillenbaum G, Heyman A. Consortium to establish a Registry for Alzheimer's Disease (CERAD): clinical and neuropsychological assessment of Alzheimer's disease. Psychopharmacol Bull 1988;24:641-652.
- Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Meas 1977;1:385-401.
- Pfeffer RI, Kurosaki TT, Harrah CH, Chance JM, Filos S. Measurement of functional activities in older adults in the community. J Gerontol 1982;37:323-329.
- Nelson HE, O'Connell A. Dementia: the estimation of premorbid intelligence using the New Adult Reading Test. Cortex 1978;14:234-244.
- McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944.
- Checkoway H Pearce NE Crawford-Brown DJ. Research methods in occupational epidemiology monographs in epidemiology and biostatistics vol 13. New York: Oxford University Press 1989:153-155.
- Aspirin Myocardial Infarction Study Group. A randomized controlled trial of aspirin in persons recovered from myocardial infarction. JAMA 1980;243:661-669.
- Paulas HE. Nonsteroidal anti-inflammatory drugs. In: Kelley WN Harris ED Ruddy S Sledge CB eds. A textbook of rheumatology. Philadelphia: WB Saunders 1989.
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Nabi, S. U., Khan, A., Siddiqui, E. M., Rehman, M. U., Alshahrani, S., Arafah, A. M., Mehan, S., Alsaffar, R. M., Alexiou, A. T., & Shen, B. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4759963 · Cited by 51
Seripa, D., Matera, M. G., Forno, G. D., Gravina, C., Masullo, C., Daniele, A., Binetti, G. G., Bonvicini, C., Squitti, R., Palermo, M. T., et al. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.04.001 · Cited by 45
Maślińska, D., Laure‐Kamionowska, M., Maslinski, K. T., Gujski, M., & Maśliński, S. (2007) · Inflammation Research · doi:10.1007/s00011-006-0508-8 · Cited by 45
Vural, P., Değirmencioğlu, S., Parıldar‐Karpuzoğlu, H., Doğru‐Abbasoğlu, S., Hanagasi, H. A., Karadağ, B., Gurvit, H. I., Emre, M., & Uysal, M. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2009.01230.x · Cited by 46
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Grazina, M. M., Pratas, J., Silva, F., Oliveira, S. A., Santana, I. J., & Oliveira, C. R. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00225.x · Cited by 47
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Waldstein, S. R., Wendell, C. R., Seliger, S. L., Ferrucci, L., Metter, E. J., & Zonderman, A. B. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02618.x · Cited by 44
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Mrak, R. E., & Landreth, G. E. (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-5 · Cited by 44
Newby, D., Prieto‐Alhambra, D., Duarte‐Salles, T., Ansell, D., Pedersen, L. H., van der Lei, J., Mosseveld, M., Rijnbeek, P. R., James, G., Alexander, M., et al. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00606-5 · Cited by 45
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Somfai, G. M., Knippel, B., Ruzicska, É., Stadler, K., Tóth, M., Salacz, G., Magyar, K., & Somogyi, A. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.009 · Cited by 44
Prevention of brain aging and dementia
Ball, L. J., & Birge, S. J. (2002) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(02)00027-7 · Cited by 42
Autotoxicity and Alzheimer Disease
McGeer, P. L., & McGeer, E. G. (2000) · Archives of Neurology · doi:10.1001/archneur.57.6.789 · Cited by 44
Protective effect of irisin against Alzheimer’s disease
Chen, K., Wang, K., & Wang, T. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.967683 · Cited by 44
Bulic, B., Neß, J., Hahn, S., Rennhack, A., Jumpertz, T., & Weggen, S. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376352 · Cited by 43
Kern, S., Skoog, I. G., Östling, S., Kern, J., & Börjesson‐Hanson, A. (2012) · BMJ Open · doi:10.1136/bmjopen-2012-001288 · Cited by 43
Barmpa, A., Hatzidimitriou, A. G., & Psomas, G. (2021) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2021.111357 · Cited by 43
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Henry, R. G., & Wekstein, D. R. (1997) · Dental Clinics of North America · doi:10.1016/s0011-8532(22)00051-9 · Cited by 44
Vasconcelos, A. R., Kinoshita, P. F., Yshii, L., Orellana, A. M., Böhmer, A. E., Lima, L. D. S., Alves, R., Andreotti, D. Z., Marcourakis, T., Scavone, C., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.02.020 · Cited by 42
Impact of the Type and Severity of Dementia on Hospitalization and Survival of the Elderly
Landi, F., Gambassi, G., Lapane, K. L., Sgadari, A., Mor, V., & Bernabei, R. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017112 · Cited by 42
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Aisen, P. S. S., & Pasinetti, G. M. (1998) · Drugs & Aging · doi:10.2165/00002512-199812010-00001 · Cited by 42
Fagan, S. G., Béchet, S., & Dev, K. K. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02613-5 · Cited by 41
Klaver, D. W., Wilce, M. C. J., Cui, H., Hung, A. C., Gasperini, R., Foa, L. C., & Small, D. H. (2010) · Biological Chemistry · doi:10.1515/bc.2010.089 · Cited by 41
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Birge, S. J., & Mortel, K. F. (1997) · The American Journal of Medicine · doi:10.1016/s0002-9343(97)00258-1 · Cited by 40
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Szekely, C. A., Breitner, J. C. S., & Zandi, P. P. (2007) · International Review of Psychiatry · doi:10.1080/09540260701797944 · Cited by 41
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Salomon, R. G., & Bi, W.-Z. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6154 · Cited by 40
Upadhyay, A., Amanullah, A., Joshi, V., Dhiman, R., Prajapati, V. K., Poluri, K. M., & Mishra, A. (2021) · Drug Metabolism Reviews · doi:10.1080/03602532.2021.1903488 · Cited by 40
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Trinh, P. N. H., Baltos, J., Hellyer, S. D., May, L. T., & Gregory, K. J. (2022) · Purinergic Signalling · doi:10.1007/s11302-022-09883-1 · Cited by 43
Kosloski, L. M., Ha, D. M., Hutter-Saunders, J. A. L., Stone, D. K., Pichler, M. R., Reynolds, A. D., Gendelman, H. E., & Mosley, R. L. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06834.x · Cited by 40
Mannila, A., Rautio, J., Lehtonen, M., Järvinen, T., & Savolainen, J. (2004) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2004.10.004 · Cited by 40
Holroyd, S., & Shepherd, M. L. (2001) · Survey of Ophthalmology · doi:10.1016/s0039-6257(01)00193-x · Cited by 39
Lee, H., Villacreses, N., Rapoport, S., & Rosenberger, T. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02786.x · Cited by 41
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Rocha, N. P., Teixeira, A. L., Coelho, F. M., Caramelli, P., Guimarães, H. C., Barbosa, I. G., Silva, T. A., Mukhamedyarov, M. A., Zefirov, A. L., Rizvanov, A. A., et al. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.09.005 · Cited by 39
Coppola, J. M., Hamilton, C. A., Bhojani, M. S., Larsen, M. J., Ross, B. D., & Rehemtulla, A. (2007) · Analytical Biochemistry · doi:10.1016/j.ab.2007.01.013 · Cited by 38
Bour, A. M. J. J., Westendorp, R. G. J., Laterveer, J. C., Bollen, E. L. E. M., & Remarque, E. J. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00128-5 · Cited by 38
Wilhelmus, M. M. M., Boelens, W. C., Kox, M., Maat–Schieman, M. L. C., Veerhuis, R., de Waal, R. M. W., & Verbeek, M. M. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.06.001 · Cited by 38
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Can peripheral leukocytes be used as Alzheimer’s disease biomarkers?
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Shie, F., Montine, K. S., BREYER, R. M., & Montine, T. J. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2005.tb00509.x · Cited by 37
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Beeri, M. S., Schmeidler, J., Lesser, G. T., Maroukian, M., West, R. K., Leung, S., Wysocki, M., Perl, D. P., Purohit, D. P., & Haroutunian, V. H. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.02.011 · Cited by 36
Watterson, D., Mirzoeva, S., Guo, L.-Y., Whyte, A., Bourguignon, J., Hibert, M., Haiech, J., & Eldik, L. V. V. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00053-5 · Cited by 33
Saeedi, M., & Mehranfar, F. (2022) · Recent Patents on Biotechnology · doi:10.2174/1872208316666220302115901 · Cited by 36
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Cervilla, J. A. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.028076 · Cited by 34
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Lynch, M. A., & Mills, K. H. G. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.05.013 · Cited by 34
Tschanz, J. T., Treiber, K., Norton, M. C., Welsh-Bohmer, K. A., Toone, L., Zandi, P. P., Szekely, C. A., Lyketsos, C. G., Breitner, J. C. S., & The Cache County Study Group (2005) · Care management journals · doi:10.1891/cmaj.6.2.107 · Cited by 32
Ibuprofen treatment modifies cortical sources of EEG rhythms in mild Alzheimer’s disease
Babiloni, C., Frisoni, G. B., Percio, C. D., Zanetti, O. O., Bonomini, C., Cassetta, E., Pasqualetti, P., Miniussi, C., Rosas, M. D., Valenzano, A. A., et al. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.02.005 · Cited by 33
Kata, D., Földesi, I., Fehér, L. Z., Hackler, L., Puskás, L. G., & Gulya, K. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.05.009 · Cited by 34
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Miller, M. L., Kress, A. M., & Berry, C. A. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199910)12:5 · Cited by 27
Landolfi, C., Soldo, L., Polenzani, L., Apicella, C., de Joannon, A. C., Coletta, I., Cesare, F. D., Brufani, M., Pinza, M., & Milanese, C. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00663-3 · Cited by 33
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Karplus, T. M., & Saag, K. G. (1998) · Drug Safety · doi:10.2165/00002018-199819060-00001 · Cited by 33
Lu, Y., Tang, Z., Ye, Z., Wang, H., Huang, Y., Zhou, K., Zhang, M., Xu, T. L., & Chen, L. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00321.x · Cited by 32
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Dias, I. H. K., Brown, C. L., Shabir, K., Polidori, M. C., & Griffiths, H. R. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180201 · Cited by 32
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Scorer, C. A. (2001) · Drug Discovery Today · doi:10.1016/s1359-6446(01)02042-6 · Cited by 32
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Flynn, B. L., & Theesen, K. A. (1999) · Annals of Pharmacotherapy · doi:10.1345/aph.17093 · Cited by 31
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Wang, B., Zhou, S., Yang, Z., Xie, Y., Wang, J., Zhang, P., Lv, Z., Zheng, C., & Ma, X. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.02.021 · Cited by 30
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Stone, T. W., Behan, W. M. H., Jones, P. A., Darlington, L. G., & Smith, R. A. (2001) · Journal of Alzheimer s Disease · doi:10.3233/jad-2001-3401 · Cited by 30
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Ano, Y., Kutsukake, T., Hoshi, A., Yoshida, A., & Nakayama, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116598 · Cited by 29
Spielman, L. A., Winger, D. I., Ho, L., Aisen, P. S. S., Shohami, E., & Pasinetti, G. M. (2002) · Acta Neuropathologica · doi:10.1007/s004010100447 · Cited by 30
Kawamoto, E. M., Scavone, C., Mattson, M. P., & Camandola, S. (2012) · Neurosignals · doi:10.1159/000336074 · Cited by 30
Bickel, H. (1999) · Springer eBooks · doi:10.1007/978-3-642-60228-3_2 · Cited by 30
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Lyketsos, C. G., Szekely, C. A., Mielke, M. M., Rosenberg, P. B., & Zandi, P. P. (2008) · International Psychogeriatrics · doi:10.1017/s1041610208007382 · Cited by 28
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Metadata
- Authors
- Stewart, W. F., Kawas, C., Corrada, M., & Metter, E. J.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Neurology
- Published
- 1997-03
- Volume
- 48
- Issue
- 3
- Pages
- 626-632
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2163110760
- Cited by
- 1,132
- References
- 16
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 13 · 2023: 22 · 2022: 19 · 2021: 22 · 2020: 23 · 2019: 22 · 2018: 21 · 2017: 24 · 2016: 28 · 2015: 29 · 2014: 32 · 2013: 24 · 2012: 31
- FWCI
- 42.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- American Academy of Neurology
- National Institutes of Health
- National Institute on Aging (R01AG008325, R01-AG08325)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
- Keywords
- Alzheimer's disease, nonsteroidal anti-inflammatory drugs, aspirin, paracetamol, medication use, neuroprotection, neuroinflammation
- MeSH terms
- Acetaminophen, Aged, Aged, 80 and over, Alzheimer Disease, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Confidence Intervals, Risk Assessment
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