Risk of Alzheimer's disease and duration of NSAID use

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404

Boston Naming Test

Kaplan, E., Goodglass, H., Weıntraub, S., & Segal, O. (2001) · Medical Entomology and Zoology · Cited by 4,378

Bayes Estimates for the Linear Model

Lindley, D. V., & Smith, A. F. M. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00885.x · Cited by 2,025

Normal Human Aging: The Baltimore Longitudinal Study on Aging

Shock, N. W., Greulich, R. C., Costa, P. T., Andres, R., Lakatta, E. G., Arenberg, D., & Tobin, J. D. (1984) · University Libraries (University of Maryland) · doi:10.13016/sclw-iccq · Cited by 757

Inverse association of anti‐inflammatory treatments and Alzheimer's disease

Breitner, J. C. S., Gau, B. A., Welsh-Bohmer, K. A., Plassman, B. L., McDonald, W. M., Helms, M. J., & Anthony, J. C. (1994) · Neurology · doi:10.1212/wnl.44.2.227 · Cited by 569

Activation of the classical complement pathway in brain tissue of Alzheimer patients

McGeer, P. L., Akiyama, H., Itagaki, S., & McGeer, E. G. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90843-4 · Cited by 383

Isolation and partial characterization of a fatty acid binding protein in rat liver plasma membranes.

Stremmel, W., Strohmeyer, G. W., Borchard, F., Kochwa, S., & Berk, P. D. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.1.4 · Cited by 350

A Population-Based Study of the Risk of Recurrence of Birth Defects

Lie, R. T., Wilcox, A. J., & Skjærven, R. (1994) · New England Journal of Medicine · doi:10.1056/nejm199407073310101 · Cited by 164

Social adjustment and psychopathology among formerly hospitalized and non-hospitalized mothers—I. Development of the social role adjustment instrument

Cohler, B. J., ROBBINS, D. M., Hartman, C. R., Shader, R. I., Grunebaum, H. U., Gallant, D. H., & Weiss, J. L. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90017-5 · Cited by 132

The need for multiple time points in aging studies

Coleman, P. A., Finch, C. E., & Joseph, J. A. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90055-5 · Cited by 66

Inflammation and Alzheimer’s disease

Lee, Y.-J., Han, S. B., Nam, S.-Y., Oh, K.-W., & Hong, J. T. (2010) · Archives of Pharmacal Research · doi:10.1007/s12272-010-1006-7 · Cited by 396

Cyclo‐oxygenase‐2: pharmacology, physiology, biochemistry and relevance to NSAID therapy

Mitchell, J. A., & Warner, T. D. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702897 · Cited by 324

Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease

Patel, N. S., Paris, D., Mathura, V. S., Quadros, A., Crawford, F., & MULLAN, M. J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-9 · Cited by 335

Reduced incidence of AD with NSAID but not H2receptor antagonists

Zandi, P. P., Anthony, J. C., Hayden, K. M., Mehta, K. M., Mayer, L. S., & Breitner, J. C. S. (2002) · Neurology · doi:10.1212/wnl.59.6.880 · Cited by 317

Cyclopentenone prostaglandins suppress activation of microglia: Down-regulation of inducible nitric-oxide synthase by 15-deoxy-Δ 12,14 -prostaglandin J 2

Petrova, T. V., Akama, K. T., & Eldik, L. J. V. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4668 · Cited by 311

Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.

Weiner, H. L., Lemere, C. A., Maron, R., Spooner, E. T., Grenfell, T. J., Mori, C., Issazadeh‐Navikas, S., Hancock, W. W., & Selkoe, D. J. (2000) · PubMed · Cited by 310

Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS

Drachman, D. B., Frank, K., Dykes‐Hoberg, M., Teismann, P., Almer, G., Przedborski, S., & Rothstein, J. D. (2002) · Annals of Neurology · doi:10.1002/ana.10374 · Cited by 307

Myocardial Inflammation Predicts Remodeling and Neuroinflammation After Myocardial Infarction

Thackeray, J. T., Hupe, H. C., Wang, Y., Bankstahl, J. P., Berding, G., Roß, T. L., Bauersachs, J. K., Wollert, K. C., & Bengel, F. M. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.024 · Cited by 309

Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease

Jaturapatporn, D., Isaac, M. G. E. K. N., McCleery, J. M., & Tabet, N. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006378.pub2 · Cited by 311

Biochemistry of Cyclooxygenase (COX)-2 Inhibitors and Molecular Pathology of COX-2 in Neoplasia

Fosslien, E. (2000) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360091174286 · Cited by 294

Alzheimer disease, the two-hit hypothesis: An update

Zhu, X., Lee, H., Perry, G. L., & Smith, M. A. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2006.10.014 · Cited by 299

Cyclooxygenase 2—implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives

Halter, F., TARNAWSKI, A. S., SCHMASSMANN, A., & PESKAR, B. M. (2001) · Gut · doi:10.1136/gut.49.3.443 · Cited by 286

Cyclooxygenases and the Central Nervous System

Kaufmann, W. E., Andreasson, K. I., Isakson, P. C., & Worley, P. F. (1997) · Prostaglandins · doi:10.1016/s0090-6980(97)00128-7 · Cited by 283

Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid β42 Production by Direct Modulation of γ-Secretase Activity

Weggen, S., Eriksen, J. L., Sagi, S. A., Pietrzik, C. U., Ozols, V. V., Fauq, A. H., Golde, T. E., & Koo, E. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303592200 · Cited by 284

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

Jin, J.-J., Kim, H.-D., Maxwell, J. A., Li, L., & Fukuchi, K. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-23 · Cited by 279

Cholinesterase Inhibitors for Alzheimer??s Disease

Grutzendler, J., & Morris, J. C. (2001) · Drugs · doi:10.2165/00003495-200161010-00005 · Cited by 273

Peroxisome Proliferator-Activated Receptor-γ Ligands Reduce Neuronal Inducible Nitric Oxide Synthase Expression and Cell DeathIn Vivo

Heneka, M. T., Klockgether, T., & Feinstein, D. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06862.2000 · Cited by 269

Alzheimer's disease and angiogenesis

Vagnucci, A. H., & Li, W. W. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12521-4 · Cited by 267

Seizures accelerate anoxia-induced neuronal death in the neonatal rat hippocampus

Dzhala, V. I., Ben‐Ari, Y., & Khazipov, R. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200010)48:4 · Cited by 82

Microglia and neuroprotection: From in vitro studies to therapeutic applications

Polazzi, E., & Monti, B. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.06.009 · Cited by 269

Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice

Janelsins, M. C., Mastrangelo, M. A., Oddo, S., LaFerla, F. M., Federoff, H. J., & Bowers, W. J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-23 · Cited by 260

Noradrenergic Depletion Potentiates β-Amyloid-Induced Cortical Inflammation: Implications for Alzheimer's Disease

Heneka, M. T., Galea, E., Gavriluyk, V., Dumitrescu‐Ozimek, L., Daeschner, J., O’Banion, M. K., Weinberg, G. L., Klockgether, T., & Feinstein, D. L. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02434.2002 · Cited by 255

Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice

Gong, Z., Huang, J., Xu, B., Ou, Z., Zhang, L., Lin, X., Ye, X., Kong, X., Long, D., Sun, X., et al. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1450-3 · Cited by 265

Aging‐dependent changes of microglial cells and their relevance for neurodegenerative disorders

Von Bernhardi, R., Tichauer, J. E., & Eugenín, J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06537.x · Cited by 258

Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy

Zotova, E., Nicoll, J. A. R., Kalaria, R. N., Holmes, C., & Boche, D. (2010) · Alzheimer s Research & Therapy · doi:10.1186/alzrt24 · Cited by 269

Local Neuroinflammation and the Progression of Alzheimer's Disease

McGeer, P. L., & McGeer, E. G. (2002) · Journal of NeuroVirology · doi:10.1080/13550280290100969 · Cited by 257

Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases

Frankola, K. A., Greig, N. H., Luo, W., & Tweedie, D. (2011) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152711794653751 · Cited by 255

The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies

Voulgaropoulou, S. D., van Amelsvoort, T. A. M. J., Prickaerts, J., & Vingerhoets, C. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146476 · Cited by 243

Are NSAIDs useful to treat Alzheimer’s disease or mild cognitive impairment

Imbimbo (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00019 · Cited by 75

Cyclooxygenase-2 Biology

Clària, J. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033454054 · Cited by 238

Targeting Neuroinflammation to Treat Alzheimer’s Disease

Ardura-Fabregat, A., Boddeke, E., Boza‐Serrano, A., Brioschi, S., Castro‐Gomez, S., Ceyzériat, K., Dansokho, C., Dierkes, T., Gelders, G., Heneka, M. T., et al. (2017) · CNS Drugs · doi:10.1007/s40263-017-0483-3 · Cited by 241

The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease.

Wilkinson, B. L., & Landreth, G. E. (2006) · Journal of Neuroinflammation · doi:10.1186/1742-2094-3-30 · Cited by 238

Age-Dependent Cognitive Deficits and Neuronal Apoptosis in Cyclooxygenase-2 Transgenic Mice

Andreasson, K. I., Savonenko, A. V., Vidensky, S., Goellner, J. J., Zhang, Y., Shaffer, A. F., Kaufmann, W. E., Worley, P. F., Isakson, P. C., & Markowska, A. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08198.2001 · Cited by 232

Pharmacotherapies for Alzheimer's disease: Beyond cholinesterase inhibitors

Tayeb, H. O., Yang, H. D., Price, B. H., & Tarazi, F. I. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.12.002 · Cited by 237

Deletion of the Prostaglandin E2EP2 Receptor Reduces Oxidative Damage and Amyloid Burden in a Model of Alzheimer's Disease

Liang, X., Wang, Q., Hand, T. A., Wu, L., BREYER, R. M., Montine, T. J., & Andreasson, K. I. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3591-05.2005 · Cited by 232

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

Lim, G. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00299-8 · Cited by 232

Inflammation, anti-inflammatory agents and Alzheimer disease: The last 12 years

McGeer, P. L., Rogers, J., & McGeer, E. G. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9s330 · Cited by 222

Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists

Anthony, J. C., Breitner, J. C. S., Zandi, P. P., Meyer, M. R., Jurasova, I., Norton, M. C., & Stone, S. V. (2000) · Neurology · doi:10.1212/wnl.54.11.2066 · Cited by 222

Non‐steroidal anti‐inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action

Gasparini, L., Ongini, E., & Wenk, G. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02743.x · Cited by 226

Alzheimer's disease and angiogenesis

Agorogiannis, E. I., & Agorogiannis, G. I. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13000-0 · Cited by 224

Prostaglandins in Health and Disease: An Overview

Miller, S. B. (2006) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2006.03.005 · Cited by 223

Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity

Kotilinek, L., Westerman, M. A., Wang, Q., Panizzon, K. L., Lim, G. P., Simonyi, Á., Lesné, S., Falinska, A. M., Younkin, L. H., Younkin, S. G., et al. (2008) · Brain · doi:10.1093/brain/awn008 · Cited by 223

Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains

Shi, J.-Q., Shen, W., Chen, J., Wang, B.-R., Zhong, L.-L., Zhu, Y.-W., Zhu, H.-Q., Zhang, Q.-Q., Zhang, Y.-D., & Xu, J. (2011) · Brain Research · doi:10.1016/j.brainres.2010.10.053 · Cited by 219

Emerging roles of PGE2 receptors in models of neurological disease

Andreasson, K. I. (2009) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2009.04.003 · Cited by 225

Inflammation, Antiinflammatory Agents, and Alzheimer’s Disease: The Last 22 Years

McGeer, P. L., Rogers, J., & McGeer, E. G. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-160488 · Cited by 215

Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment.

Vasconcelos, A. R., Yshii, L. M., Viel, T. A., Buck, H. S., Mattson, M. P., Scavone, C., & Kawamoto, E. M. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-85 · Cited by 210

Glucagon-like peptide-1 inhibits LPS-induced IL-1β production in cultured rat astrocytes

Iwai, T., Ito, S., Tanimitsu, K., Udagawa, S., & Oka, J.-I. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.04.008 · Cited by 207

Alzheimer’s Disease And Inflammation: A Review Of Cellular And Therapeutic Mechanisms

Halliday, G. M., Robinson, S. R., Shepherd, C. E., & Kril, J. J. (2000) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2000.03200.x · Cited by 209

Anti-inflammatory properties of cholinergic up-regulation: A new role for acetylcholinesterase inhibitors

Nizri‏, E., Hamra‐Amitay, Y., Sicsic, C., Lavon, I., & Brenner, T. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.10.013 · Cited by 208

COX-2 inhibitors in cancer treatment and prevention, a recent development

Xu, X.-C. (2002) · Anti-Cancer Drugs · doi:10.1097/00001813-200202000-00003 · Cited by 206

Aβ-Induced Inflammatory Processes in Microglia Cells of APP23 Transgenic Mice

Bornemann, K. D., Wiederhold, K., Pauli, C., Ermini, F., Stalder, M., Schnell, L., Sommer, B., Jucker, M., & Staufenbiel, M. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63945-4 · Cited by 206

Amyloid β and Amylin Fibrils Induce Increases in Proinflammatory Cytokine and Chemokine Production by THP‐1 Cells and Murine Microglia

Yates, S. L., Burgess, L. H., Kocsis‐Angle, J., Antal, J. M., Dority, M. D., Embury, P. B., Piotrkowski, A. M., & Brunden, K. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741017.x · Cited by 202

NSAID use and dementia risk in the Cardiovascular Health Study*: Role of APOE and NSAID type

Szekely, C. A., Breitner, J. C. S., Fitzpatrick, A. L., Rea, T. D., Psaty, B. M., Kuller, L. H., & Zandi, P. P. (2008) · Neurology · doi:10.1212/01.wnl.0000284596.95156.48 · Cited by 204

NADPH oxidase as a therapeutic target in Alzheimer's disease

Block, M. L. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-s2-s8 · Cited by 203

The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease

Aisen, P. S. S. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00133-3 · Cited by 203

Emerging roles of pathogens in Alzheimer disease

Miklossy, J. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411002006 · Cited by 206

Alzheimer Disease

Smith, M. A. (1998) · International review of neurobiology · doi:10.1016/s0074-7742(08)60607-8 · Cited by 206

Non-Steroidal Anti-Inflammatory Drugs as a Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Treatment Effect

Miguel-Álvarez, M., Santos‐Lozano, A., Sanchis‐Gomar, F., Fiuza‐Luces, C., Pareja-Galeano, H., Garatachea, N., & Lucía, A. (2015) · Drugs & Aging · doi:10.1007/s40266-015-0239-z · Cited by 197

Neuronal Cyclooxygenase 2 Expression in the Hippocampal Formation as a Function of the Clinical Progression of Alzheimer Disease

Ho, L., Purohit, D. P., Haroutunian, V. H., Luterman, J. D., Willis, F., Näslund, J., Buxbaum, J. D., Mohs, R. C., Aisen, P. S. S., & Pasinetti, G. M. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.487 · Cited by 197

The Role of Inflammation in the Pathogenesis of Delirium and Dementia in Older Adults: A Review

Simone, M. J., & Tan, Z. S. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00173.x · Cited by 204

Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1beta and inducible nitric oxide synthase in the rat model of Alzheimer's disease

Zhu, F., & Qian, C. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-78 · Cited by 200

Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti‐inflammatory drugs

Townsend, K. P., & Praticò, D. (2005) · The FASEB Journal · doi:10.1096/fj.04-3620rev · Cited by 194

EPIDEMIOLOGY OF DEMENTIA

Kukull, W. A., & Ganguli, M. (2000) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70233-4 · Cited by 194

Cyclooxygenase-2: its rich diversity of roles and possible application of its selective inhibitors

Katori, M., & Majima, M. (2000) · Inflammation Research · doi:10.1007/s000110050605 · Cited by 193

Pleiotropic roles of formyl peptide receptors

Le, Y., Oppenheim, J. J., & Wang, J. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(01)00003-x · Cited by 193

Cloning and functional analysis of the allelic polymorphism in the transcription regulatory region of interleukin-1α

Dominici, R., Cattaneo, M., Malferrari, G., Archi, D., Mariani, C. B., Grimaldi, L. M. E., & Biunno, I. (2002) · Immunogenetics · doi:10.1007/s00251-002-0445-9 · Cited by 193

Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms

Rommy von Bernhardi, M., & Eugenín, J. L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4082 · Cited by 193

Neuroprotective effects of non‐steroidal anti‐inflammatory drugs by direct scavenging of nitric oxide radicals

Asanuma, M., Nishibayashi-Asanuma, S., Miyazaki, I., Kohno, M., & Ogawa, N. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00205.x · Cited by 190

Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging

Mackenzie, I. R. A., & Munoz, D. G. (1998) · Neurology · doi:10.1212/wnl.50.4.986 · Cited by 244

Prostaglandin D2-Mediated Microglia/Astrocyte Interaction Enhances Astrogliosis and Demyelination intwitcher

Mohri, I., Taniike, M., Taniguchi, H., Kanekiyo, T., Aritake, K., Inui, T., Fukumoto, N., Eguchi, N., Kushi, A., Sasai, H., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4531-05.2006 · Cited by 185

Immunological aspects of microglia: relevance to Alzheimer's disease

Benveniste, E. N., Nguyen, V. T., & O'Keefe, G. M. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00045-6 · Cited by 189

Reactive Oxygen Species Mediate Cellular Damage in Alzheimer Disease

Perry, G. L., Castellani, R. J., Hirai, K., & Smith, M. A. (1998) · Journal of Alzheimer s Disease · doi:10.3233/jad-1998-1103 · Cited by 184

Modes of action of aspirin-like drugs: Salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion

Pillinger, M. H., Capodici, C., Rosenthal, P., Kheterpal, N., Hanft, S. J., Philips, M. R., & Weissmann, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14540 · Cited by 181

Shortened onset of action of antidepressants in major depression using acetylsalicylic acid augmentation: a pilot open-label study

Mendlewicz, J., Kriwin, P., Oswald, P., Souery, D., Alboni, S., & Brunello, N. (2006) · International Clinical Psychopharmacology · doi:10.1097/00004850-200607000-00005 · Cited by 229

Can oral infection be a risk factor for Alzheimer's disease?

Olsen, I., & Singhrao, S. K. (2015) · Journal of Oral Microbiology · doi:10.3402/jom.v7.29143 · Cited by 192

Over-the-counter analgesics and antipyretics: A critical assessment

Hersh, E. V., Moore, P. A., & Ross, G. L. (2000) · Clinical Therapeutics · doi:10.1016/s0149-2918(00)80043-0 · Cited by 180

Neuroinflammation in Alzheimer’s disease; A source of heterogeneity and target for personalized therapy

Latta, C. H., Brothers, H. M., & Wilcock, D. M. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.061 · Cited by 188

Microglia as a Potential Bridge between the Amyloid β‐Peptide and Tau

Kitazawa, M., Yamasaki, T. R., & LaFerla, F. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.006 · Cited by 187

Toll-Like Receptors in Alzheimer's Disease

Landreth, G. E., & Reed-Geaghan, E. G. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-00549-7_8 · Cited by 180

Prolonged Activation of NF-κB Following Traumatic Brain Injury in Rats

NONAKA, M., CHEN, X.-H., PIERCE, J. E. S., LEONI, M. J., McINTOSH, T. K., WOLF, J. A., & SMITH, D. H. (1999) · Journal of Neurotrauma · doi:10.1089/neu.1999.16.1023 · Cited by 176

Randomized pilot study of nimesulide treatment in Alzheimer’s disease

Aisen, P. S. S., Schmeidler, J., & Pasinetti, G. M. (2002) · Neurology · doi:10.1212/wnl.58.7.1050 · Cited by 179

NSAID Exposure and Risk of Alzheimer's Disease: An Updated Meta-Analysis From Cohort Studies

Zhang, C., Wang, Y., Wang, D., Zhang, J., & Zhang, F. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00083 · Cited by 184

Amyloid β-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists

Butterfield, D. A., Griffin, S. T., Münch, G. W., & Pasinetti, G. M. (2002) · Journal of Alzheimer s Disease · doi:10.3233/jad-2002-4309 · Cited by 176

Young microglia restore amyloid plaque clearance of aged microglia

Daria, A., Colombo, A., Llovera, G., Hampel, H., Willem, M., Liesz, A., Haass, C., & Tahirovic, S. (2017) · The EMBO Journal · doi:10.15252/embj.201694591 · Cited by 174

Current approaches in the treatment of Alzheimer's disease

Shah, R. S., Lee, H., Zhu, X., Perry, G. L., Smith, M. A., & Castellani, R. J. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.02.005 · Cited by 178

Estrogens, inflammation and cognition

Au, A., Feher, A., McPhee, L., Jessa, A., Oh, S. J., & Einstein, G. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.01.002 · Cited by 190

Inflammatory changes parallel the early stages of Alzheimer disease

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