Risk of Alzheimer's disease and duration of NSAID use

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404

Boston Naming Test

Kaplan, E., Goodglass, H., Weıntraub, S., & Segal, O. (2001) · Medical Entomology and Zoology · Cited by 4,378

Bayes Estimates for the Linear Model

Lindley, D. V., & Smith, A. F. M. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00885.x · Cited by 2,025

Normal Human Aging: The Baltimore Longitudinal Study on Aging

Shock, N. W., Greulich, R. C., Costa, P. T., Andres, R., Lakatta, E. G., Arenberg, D., & Tobin, J. D. (1984) · University Libraries (University of Maryland) · doi:10.13016/sclw-iccq · Cited by 757

Inverse association of anti‐inflammatory treatments and Alzheimer's disease

Breitner, J. C. S., Gau, B. A., Welsh-Bohmer, K. A., Plassman, B. L., McDonald, W. M., Helms, M. J., & Anthony, J. C. (1994) · Neurology · doi:10.1212/wnl.44.2.227 · Cited by 569

Activation of the classical complement pathway in brain tissue of Alzheimer patients

McGeer, P. L., Akiyama, H., Itagaki, S., & McGeer, E. G. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90843-4 · Cited by 383

Isolation and partial characterization of a fatty acid binding protein in rat liver plasma membranes.

Stremmel, W., Strohmeyer, G. W., Borchard, F., Kochwa, S., & Berk, P. D. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.1.4 · Cited by 350

A Population-Based Study of the Risk of Recurrence of Birth Defects

Lie, R. T., Wilcox, A. J., & Skjærven, R. (1994) · New England Journal of Medicine · doi:10.1056/nejm199407073310101 · Cited by 164

Social adjustment and psychopathology among formerly hospitalized and non-hospitalized mothers—I. Development of the social role adjustment instrument

Cohler, B. J., ROBBINS, D. M., Hartman, C. R., Shader, R. I., Grunebaum, H. U., Gallant, D. H., & Weiss, J. L. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90017-5 · Cited by 132

The need for multiple time points in aging studies

Coleman, P. A., Finch, C. E., & Joseph, J. A. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90055-5 · Cited by 66

Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs

Gao, J., Mfuh, A., Amako, Y., & Woo, C. M. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.7b11639 · Cited by 102

Aspirin for in vitro fertilisation

Siristatidis, C. S., Basios, G., Pergialiotis, V., & Vogiatzi, P. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004832.pub4 · Cited by 102

Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies

López González, I., Garcia-Esparcia, P., Llorens, F., & Ferrer, I. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020206 · Cited by 101

Aspirin and other non-steroidal anti-inflammatory drugs for the prevention of dementia

Jordan, F., Quinn, T. J., McGuinness, B., Passmore, P., Kelly, J. P., Smith, C. T., Murphy, K., & Devane, D. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011459.pub2 · Cited by 102

Regulation of β-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor α

Combs, C. K., Bates, P., Karlo, J. C., & Landreth, G. E. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00052-3 · Cited by 101

Mild cognitive impairment

Bullock, R. A. (2005) · Psychiatry · doi:10.1383/psyt.4.1.64.58310 · Cited by 101

Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration

Wilkins, H. M., Weidling, I. W., Ji, Y., & Swerdlow, R. H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00508 · Cited by 102

Oral Inflammation, Tooth Loss, Risk Factors, and Association with Progression of Alzheimer's Disease

Singhrao, S. K., Harding, A., Simmons, T. L., Robinson, S. J., Kesavalu, L. N., & Crean, S. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140387 · Cited by 100

Gastrodin alleviates memory deficits and reduces neuropathology in a mouse model of Alzheimer's disease

Hu, Y., Li, C., & Shen, W. (2014) · Neuropathology · doi:10.1111/neup.12115 · Cited by 98

New Therapeutic Strategies and Drug Candidates for Neurodegenerative Diseases: p53 and TNF‐α Inhibitors, and GLP‐1 Receptor Agonists

Greig, N. H., Mattson, M. P., Perry, T., Chan, S. L., Giordano, T., Sambamurti, K., Rogers, J. T., Ovadia, H., & Lahiri, D. K. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.018 · Cited by 99

Ginger Extract Inhibits β-Amyloid Peptide–Induced Cytokine and Chemokine Expression in Cultured THP-1 Monocytes

Grzanna, R., Phan, P. V., Polotsky, A., Lindmark, L., & Frondoza, C. G. (2004) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2004.10.1009 · Cited by 97

Do NSAIDs prevent Alzheimer's disease? And, if so, why? The epidemiological evidence

Zandi, P. P. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00297-4 · Cited by 101

Modulation of β‐amyloid metabolism by non‐steroidal anti‐inflammatory drugs in neuronal cell cultures

Gasparini, L., Rusconi, L., Xu, H., Soldato, P. D., & Ongini, E. (2003) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02154.x · Cited by 97

Impaired iron homeostasis in Parkinson’s disease

Double, K. L., Gerlach, M., Youdim, M. B. H., & Riederer, P. F. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6301-6_3 · Cited by 101

Ulva conglobata, a marine algae, has neuroprotective and anti-inflammatory effects in murine hippocampal and microglial cells

Jin, D., Lim, C. S., Sung, J., Choi, H. G., Ha, I., & Han, J. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.03.068 · Cited by 99

Inflammation in transgenic mouse models of neurodegenerative disorders

Schwab, C., Klegeris, A., & McGeer, P. L. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.10.013 · Cited by 97

Effects of Estrogen on Cognition, Mood, and Degenerative Brain Diseases

Shepherd, J. E. (2001) · Journal of the American Pharmaceutical Association (1996) · doi:10.1016/s1086-5802(16)31233-5 · Cited by 100

Pharmacologic suppression of neuronal oxidative damage and dendritic degeneration following direct activation of glial innate immunity in mouse cerebrum

Milatović, D., Zaja‐Milatovic, S., Montine, K. S., Horner, P. J., & Montine, T. J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02120.x · Cited by 96

The Treatment Strategies for Neurodegenerative Diseases by Integrative Medicine

Chen, X., & Pan, W. (2015) · Integrative Medicine International · doi:10.1159/000381546 · Cited by 96

Chapter 21. Selective Cyclooxygenase-2 Inhibitors

Prasit, P., & Riendeau, D. (1997) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(08)61479-7 · Cited by 96

Natural history of Alzheimer’s disease

Honig, L. S., & Mayeux, R. P. (2001) · Aging Clinical and Experimental Research · doi:10.1007/bf03351476 · Cited by 98

Ibuprofen Suppresses Interleukin-1β Induction of Pro-Amyloidogenic α1-Antichymotrypsin to Ameliorate β-Amyloid (Aβ) Pathology in Alzheimer's Models

Morihara, T., Teter, B., Yang, F., Lim, G. P., Boudinot, S. G., Boudinot, F. D., Frautschy, S. A., & Cole, G. M. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300668 · Cited by 96

Apoptosis modulators in the therapy of neurodegenerative diseases

Deigner, H., Haberkorn, U., & Kinscherf, R. (2000) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.9.4.747 · Cited by 94

Receptors for chemotactic formyl peptides as pharmacological targets

Le, Y., Yang, Y., Cui, Y., Yazawa, H., Gong, W., Qiu, C., & Wang, J. M. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00150-3 · Cited by 96

Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases

Lleo, A., Galea, E., & Sastre, M. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6516-1 · Cited by 93

Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease

Shi, J., Wang, Q., Johansson, J. U., Liang, X., Woodling, N. S., Priyam, P. G., Loui, T., Merchant, M. J., BREYER, R. M., Montine, T. J., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23677 · Cited by 93

EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimerʼns disease

Tai, L. M., Balu, D., Avila-Munoz, E., Abdullah, L., Thomas, R., Collins, N., Valencia-Olvera, A. C., & LaDu, M. J. (2017) · Journal of Lipid Research · doi:10.1194/jlr.r076315 · Cited by 93

The role of the immune system in neurodegenerative disorders

McGeer, E. G., & McGeer, P. L. (1997) · Movement Disorders · doi:10.1002/mds.870120604 · Cited by 93

Obovatol attenuates LPS-induced memory impairments in mice via inhibition of NF-κB signaling pathway

Choi, D., Lee, J. W., GuiHua, L., Lee, Y. K., Lee, Y. H., Choi, I. S., Han, S., Jung, J., Kim, Y. H., Kim, K. H., et al. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.11.005 · Cited by 94

Beta-amyloid activated microglia induce cell cycling and cell death in cultured cortical neurons

Wu, Q. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00219-0 · Cited by 94

The cell cycle as a therapeutic target for Alzheimer's disease

Neve, R. L., & McPhie, D. L. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.09.005 · Cited by 92

Cyclooxygenase and Alzheimer's disease: implications for preventive initiatives to slow the progression of clinical dementia

Pasinetti, G. M. (2001) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(01)00091-7 · Cited by 91

Neuroinflammation as a Potential Therapeutic Target in Alzheimer’s Disease

Liu, P., Wang, Y., Sun, Y., & Peng, G. (2022) · Clinical Interventions in Aging · doi:10.2147/cia.s357558 · Cited by 94

Contributions of cyclooxygenase-2 to neuroplasticity and neuropathology of the central nervous system

Hewett, S. J., Bell, S. C., & Hewett, J. A. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.04.011 · Cited by 91

Unregulated inflammation shortens human functional longevity

Brod, S. A. (2000) · Inflammation Research · doi:10.1007/s000110050632 · Cited by 93

Glaucoma and Aging

Guedes, G., Tsai, J. C., & Loewen, N. A. (2011) · Current Aging Science · doi:10.2174/1874609811104020110 · Cited by 92

Microbiota-gut-brain axis and toll-like receptors in Alzheimer’s disease

Lin, C., Zhao, S., Zhu, Y., Fan, Z., Wang, J., Zhang, B., & Chen, Y. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.09.008 · Cited by 94

Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis.

Yao, Y., Chinnici, C. M., Tang, H., Trojanowski, J. Q., Lee, V. M. ‐., & Praticò, D. (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-21 · Cited by 91

Review Nimesulide: Some Pharmaceutical and Pharmacological Aspects—An Update

Singla, A. K., Chawla, M., & Singh, A. K. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001774255 · Cited by 92

Aspirin and other anti-inflammatory drugs

Vane, S. J. (2000) · Thorax · doi:10.1136/thorax.55.suppl_2.s3 · Cited by 90

Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseases

Knuesel, I. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.002 · Cited by 89

Somatostatin and Alzheimer's disease

Burgos‐Ramos, E., Hervás‐Aguilar, A., Aguado‐Llera, D., Puebla‐Jiménez, L., Hernández‐Pinto, A. M., Barrios, V., & Arilla, E. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.01.014 · Cited by 88

Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases

Walker, D. G., & Lue, L.-F. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20484 · Cited by 89

Interventions for age-related diseases: Shifting the paradigm

Figueira, I., Fernandes, A. M. A., Mladenović, A., Lopez-Contreras, A. J., Henriques, C. M., Selman, C., Ferreiro, E. B., Gonos, E. S., Trejo, J. L., Misra, J., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.009 · Cited by 92

Noncovalent interaction between amyloid-β-peptide (1–40) and oleuropein studied by electrospray ionization mass spectrometry

Bazoti, F. N., Bergquist, J., Markides, K. E., & Tsarbopoulos, A. (2006) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2005.11.016 · Cited by 88

3D-Reconstruction of microglia and amyloid in APP23 transgenic mice: no evidence of intracellular amyloid

Stalder, M., Deller, T., Staufenbiel, M., & Jucker, M. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00209-3 · Cited by 118

Nonsteroidal anti-inflammatory drug use and Alzheimer’s disease: a case-control study in Rochester, Minnesota, 1980 through 1984

Beard, C. M., Waring, S. C., O'Brien, P. C., Kurland, L. T., & Kokmen, E. (1998) · Mayo Clinic Proceedings · doi:10.4065/73.10.951 · Cited by 114

Sterile Neuroinflammation and Strategies for Therapeutic Intervention

Banjara, M., & Ghosh, C. (2017) · International Journal of Inflammation · doi:10.1155/2017/8385961 · Cited by 92

Modulatory role of cyclooxygenase inhibitors in aging- and scopolamine or lipopolysaccharide-induced cognitive dysfunction in mice

Jain, N., Patil, C. S., Kulkarni, S. K., & Singh, À. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00025-6 · Cited by 87

The interplay between inflammation and neurodegeneration in CNS disease

Esiri, M. M. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.013 · Cited by 87

Nitric oxide in neurodegeneration: potential benefits of non-steroidal anti-inflammatories

Doherty, G. H. (2011) · Neuroscience Bulletin · doi:10.1007/s12264-011-1530-6 · Cited by 91

Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats.

Browne, K., Iwata, A., Putt, M., & Smith, D. H. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.04.008 · Cited by 80

Insights into the neurodegenerative process of Alzheimer's disease: a role for mononuclear phagocyte-associated inflammation and neurotoxicity

Cotter, R. L., Burke, W. J., Thomas, V. S., POTTER, J. F., Zheng, J., & Gendelman, H. E. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.4.416 · Cited by 86

Vasoactive intestinal peptide protects against β‐amyloid‐induced neurodegeneration by inhibiting microglia activation at multiple levels

Delgado, M., Varela, N., & González‐Rey, E. (2008) · Glia · doi:10.1002/glia.20681 · Cited by 87

Elevated levels of inflammatory biomarkers in the cerebrospinal fluid after coronary artery bypass surgery are predictors of cognitive decline

Kalman, J. L., Juhász, A., Bogáts, G., Babik, B., Rimanóczy, Á., Janka, Z., Penke, B., & Palotás, A. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.10.007 · Cited by 85

Attenuation of chronic neuroinflammation by a nitric oxide‐releasing derivative of the antioxidant ferulic acid

Wenk, G. L., McGann-Gramling, K. R., Hauss‐Wegrzyniak, B., Ronchetti, D., Maucci, R., Rosi, S., Gasparini, L., & Ongini, E. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02359.x · Cited by 85

Cyclooxygenase-1 null mice show reduced neuroinflammation in response to β-amyloid

Choi, S., & Bosetti, F. (2009) · Aging · doi:10.18632/aging.100021 · Cited by 87

Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis

Lee, M., McGeer, E. G., & McGeer, P. L. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.024 · Cited by 85

Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

Miron, R. J., Estrin, N. E., Sculean, A., & Zhang, Y. (2024) · Periodontology 2000 · doi:10.1111/prd.12561 · Cited by 89

Cyclooxygenase-2 Inhibitors

Gajraj, N. M. (2003) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000061461.55712.c5 · Cited by 83

The pentraxins: possible role in Alzheimer's disease and other innate inflammatory diseases.

Mcgeer, E., Yasojima, K., Schwab, C., & McGeer, P. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00288-3 · Cited by 86

Interleukin-1β with learning and memory

Huang, Z., & Sheng, G. (2010) · Neuroscience Bulletin · doi:10.1007/s12264-010-6023-5 · Cited by 89

Inflammaging and Brain Aging

Jurcău, M. C., Jurcău, A., Cristian, A., Hogea, V. O., Diaconu, R. G., & Nunkoo, V. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910535 · Cited by 100

Immunological Aetiology of Major Psychiatric Disorders

Sperner‐Unterweger, B. (2005) · Drugs · doi:10.2165/00003495-200565110-00004 · Cited by 83

Non-steroidal Anti-inflammatory Drugs Stimulate Secretion of Non-amyloidogenic Precursor Protein

Avramovich‐Tirosh, Y., Amit, T., & Youdim, M. B. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201308200 · Cited by 86

Different pathways for iNOS‐mediated toxicity in vitro dependent on neuronal maturation and NMDA receptor expression

Golde, S., Chandran, S., Brown, G. C., & Compston, A. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00973.x · Cited by 77

New drugs for Alzheimer's disease and other dementias

Bullock, R. A. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.180.2.135 · Cited by 79

NSAIDS inhibit the IL-1β-induced IL-6 release from human post-mortem astrocytes: the involvement of prostaglandin E2

Blom, M. A. A., van Twillert, M. G. H., de Vries, S. C., Engels, F., Finch, C. E., Veerhuis, R., & Eikelenboom, P. (1997) · Brain Research · doi:10.1016/s0006-8993(97)01204-3 · Cited by 79

Synthesis and pharmacological evaluation of amide conjugates of NSAIDs with L-cysteine ethyl ester, combining potent antiinflammatory and antioxidant properties with significantly reduced gastrointestinal toxicity

Galanakis, D., Kourounakis, A. P., Tsiakitzis, K. C., Doulgkeris, C. M., Rekka, E. A., Gavalas, A. M., Kravaritou, C., Charitos, C., & Kourounakis, P. N. (2004) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2004.05.025 · Cited by 78

Potential role of the formyl peptide receptor-like 1 (FPRL1) in inflammatory aspects of Alzheimer's disease

Cui, Y., Le, Y., Yazawa, H., Gong, W., & Wang, J. M. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.4.628 · Cited by 79

Cardiovascular factors in Alzheimer's disease

Stewart, R. J. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.65.2.143 · Cited by 78

DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer’s Disease

Madrid, A., Hogan, K. J., Papale, L. A., Clark, L. R., Asthana, S., Johnson, S. C., & Alisch, R. S. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-180592 · Cited by 77

Effect of Boswellia serrata on Alzheimer′s disease induced in rats

Yassin, N., El-Shenawy, S. M. A., Mahdy, K., Gouda, N. A., Marrie, A. E.-F. H., Farrag, A. R., & Ibrahim, B. M. M. (2013) · Journal of The Arab Society for Medical Research · doi:10.4103/1687-4293.132766 · Cited by 77

Increase in level of tumor necrosis factor (TNF)-α in 6-hydroxydopamine-lesioned striatum in rats without influence of systemic l-DOPA on the TNF-α induction

Mogi, M., Togari, A., Tanaka, K., Ogawa, N., Ichinose, H., & Nagatsu, T. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00388-2 · Cited by 77

Selective Modulation of BV-2 Microglial Activation by Prostaglandin E2

Petrova, T. V., Akama, K. T., & Eldik, L. J. V. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28823 · Cited by 77

Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study

Yip, A. G., Green, R. C., Huyck, M., Cupples, L. A., Farrer, L. A., & for the MIRAGE Study Group (2005) · BMC Geriatrics · doi:10.1186/1471-2318-5-2 · Cited by 79

Perturbations in calcium‐mediated signal transduction in microglia from Alzheimer's disease patients

McLarnon, J. G., Choi, H. B., Lue, L., Walker, D. G., & Kim, S. U. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20487 · Cited by 73

Proinflammatory and Vasoactive Effects of Aβ in the Cerebrovasculature

Townsend, K. P., Obregon, D. F., QUADROS, A., Patel, N. S., Volmar, C., Paris, D., & MULLAN, M. J. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04799.x · Cited by 77

The clinical potential of cyclooxygenase-2–specific inhibitors

Lipsky, P. E. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00117-5 · Cited by 74

Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs)

Klegeris, A., Walker, D. G., & McGeer, P. L. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00014-3 · Cited by 75

2D QSAR Consensus Prediction for High-Throughput Virtual Screening. An Application to COX-2 Inhibition Modeling and Screening of the NCI Database

Baurin, N., Mozziconacci, J., Arnoult, É., Chavatte, P., Marot, C., & Morin‐Allory, L. (2003) · Journal of Chemical Information and Computer Sciences · doi:10.1021/ci0341565 · Cited by 76

Principles of epidemiological research on adverse and beneficial drug effects

Jick, H., Rodríguez, L. A. G., & Perez‐Gutthann, S. (1998) · The Lancet · doi:10.1016/s0140-6736(98)04350-5 · Cited by 76

Innate Immunity, Local Inflammation, and Degenerative Disease

McGeer, P. L., & McGeer, E. G. (2002) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.29.re3 · Cited by 75

Association between the TNFα‐308 A/G polymorphism and the onset‐age of Alzheimer disease

Álvarez, V., Mata, I. F., González, P., Lahoz, C., Martínez, C., Peña, J., Guisasola, L. M., & Coto, E. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10515 · Cited by 75

Tooth Loss, Apolipoprotein E, and Decline in Delayed Word Recall

Stein, P. S., Kryscio, R. J., Desrosiers, M. F., DONEGAN, S. J., & Gibbs, M. (2010) · Journal of Dental Research · doi:10.1177/0022034509357881 · Cited by 76

Evaluation of selective COX-2 inhibitors for the treatment of Alzheimer's disease.

Aisen, P. (2002) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(02)00374-3 · Cited by 74

Mechanisms of cell death in Alzheimer disease — immunopathology

McGeer, P. L., & McGeer, E. G. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-7508-8_15 · Cited by 73

Rodent Models of Amyloid-Beta Feature of Alzheimer’s Disease: Development and Potential Treatment Implications

Poon, C. H., Wang, Y., Fung, M., Zhang, C., & Lim, L. W. (2020) · Aging and Disease · doi:10.14336/ad.2019.1026 · Cited by 76

Insulin resistance, neuroinflammation, and Alzheimer’s disease

Najem, D., Bamji‐Mirza, M., Chang, N., Liu, Q. Y., & Zhang, W. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0050 · Cited by 76

The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer’s disease phenotype

Joshi, Y. B., & Praticò, D. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00436 · Cited by 75

Inflammation and Alzheimer's disease

Jones, R. W. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05667-7 · Cited by 73

Alzheimer’s Disease in 22 Twin Pairs – 13-Year Follow-Up: Hormonal, Infectious and Traumatic Factors

Nee, L. E., & Lippa, C. F. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017115 · Cited by 71

Vitamin E (alpha-tocopherol) attenuates cyclo-oxygenase 2 transcription and synthesis in immortalized murine BV-2 microglia

Egger, T., Schuligoi, R., Wintersperger, A., Amann, R., Malle, E., & Sattler, W. (2003) · Biochemical Journal · doi:10.1042/bj20021358 · Cited by 72

Natural Compounds and Plant Extracts as Therapeutics Against Chronic Inflammation in Alzheimer’s Disease – A Translational Perspective

Apetz, N., Münch, G. W., Govindaraghavan, S., & Gyengési, E. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666140917110635 · Cited by 73

Alzheimer’s disease and neuroinflammation: will new drugs in clinical trials pave the way to a multi-target therapy?

Melchiorri, D., Merlo, S., Micallef, B., Borg, J.-J., & Dráfi, F. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1196413 · Cited by 73

Acetaminophen protects hippocampal neurons and PC12 cultures from amyloid β-peptides induced oxidative stress and reduces NF-κB activation

Bisaglia, M., Venezia, V., Piccioli, P., Stanzione, S., Porcile, C., Russo, C., Mancini, F. R., Milanese, C., & Schettini, G. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(01)00136-x · Cited by 71

Inhibition of Alzheimer's β-Amyloid Induced Vasoactivity and Proinflammatory Response in Microglia by a cGMP-Dependent Mechanism

Paris, D., Town, T., Parker, T. A., Tan, J., Humphrey, J., Crawford, F., & MULLAN, M. J. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7055 · Cited by 71

Ibuprofen and apigenin induce apoptosis and cell cycle arrest in activated microglia

Elsisi, N. S., Darling‐Reed, S., Lee, E.-S., Oriaku, E. T., & Soliman, K. F. A. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.10.087 · Cited by 71

Neuronal plasticity and stressor toxicity during aging

Brewer, G. J. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00121-2 · Cited by 71

Neutrophils CD11b and fibroblasts PGE2 are elevated in Alzheimer’s disease

Scali, C., Prosperi, C., Bracco, L., Piccini, C., Baronti, R., Ginestroni, A., Sorbi, S., Pepeu, G., & Casamenti, F. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00346-3 · Cited by 68

Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies

Etminan, M., Gill, S., & Samii, A. (2003) · BMJ · doi:10.1136/bmj.327.7407.128 · Cited by 511

Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease?

Andersen, K., Launer, L. J., Ott, A., Hoes, A. W., Breteler, M. M. B., & Albert Hofman, D. (1995) · Neurology · doi:10.1212/wnl.45.8.1441 · Cited by 284

Non-Steroidal Anti-Inflammatory Drug (NSAID) Use and Alzheimer Disease in Community-Dwelling Elderly Patients

Landi, F., Cesari, M., Onder, G., Russo, A., Torre, S., & Bernabei, R. (2003) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200303000-00008 · Cited by 51

NSAIDs and incident Alzheimer’s disease. The Rotterdam study

In ’t Veld, B. A., Launer, L. J., Hoes, A. W., Ott, A., Hofman, A., Breteler, M. M. B., & Stricker, B. H. C. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00096-7 · Cited by 145

Anti-Inflammatory Drugs and Risk of Alzheimer's Disease: An Updated Systematic Review and Meta-Analysis

Wang, J., Tan, L., Wang, H.-F., Tan, C.-C., Meng, X.-F., Wang, C., Tang, S.-W., & Yu, J.-T. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-141506 · Cited by 234