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Prevalence of Alzheimer's disease and other dementias in rural India: The Indo-US study
Abstract
OBJECTIVE: To determine the prevalence of AD and other dementias in a rural elderly Hindi-speaking population in Ballabgarh in northern India. DESIGN: The authors performed a community survey of a cohort of 5,126 individuals aged 55 years and older, 73.3% of whom were illiterate. Hindi cognitive and functional screening instruments, developed for and validated in this population, were used to screen the cohort. A total of 536 subjects (10.5%) who met operational criteria for cognitive and functional impairment and a random sample of 270 unimpaired control subjects (5.3%) underwent standardized clinical assessment for dementia using the Diagnostic and Statistical Manual of Mental Disorders-fourth edition diagnostic criteria, the Clinical Dementia Rating Scale (CDR), and National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria for probable and possible AD. RESULTS: We found an overall prevalence rate of 0.84% (95% CI, 0.61 to 1.13) for all dementias with a CDR score of at least 0.5 in the population aged 55 years and older, and an overall prevalence rate of 1.36% (95% CI, 0.96 to 1.88) in the population aged 65 years and older. The overall prevalence rate for AD was 0.62% (95% CI, 0.43 to 0.88) in the population aged 55+ and 1.07% (95% CI, 0.72 to 1.53) in the population aged 65+. Greater age was associated significantly with higher prevalence of both AD and all dementias, but neither gender nor literacy was associated with prevalence. CONCLUSIONS: In this population, the prevalence of AD and other dementias was low, increased with age, and was not associated with gender or literacy. Possible explanations include low overall life expectancy, short survival with the disease, and low age-specific incidence potentially due to differences in the underlying distribution of risk and protective factors compared with populations with higher prevalence.
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Relationship Between Education and Dementia: An Updated Systematic Review
Sharp, E. S., & Gatz, M. (2011) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e318211c83c · Cited by 591
Baum, L., & Ng, A. (2004) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6403 · Cited by 483
Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis
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Implementing a screening and diagnosis program for dementia in primary care
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The protocols for the 10/66 dementia research group population-based research programme
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“From these studies, we can infer that the prevalence of dementia and Alzheimer’s disease was lower in developing or low and middle income countries [11, 12, 16, 17]; the difference between the developed and developing countries was very large in some studies (Hendrie et al., 1995; Chandra et al., 1998).”
BackgroundResultOjha, P. S., Biradar, P. R., Tubachi, S., & Patil, V. S. (2023) · Advances in Traditional Medicine · doi:10.1007/s13596-021-00627-x · Cited by 24
A unifying hypothesis of alzheimer’s disease: III—Risk factors
Heininger, K. (2000) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/(sici)1099-1077(200001)15:1<1::aid-hup153>3.0.co;2-1
Metadata
- Authors
- Chandra, V., Ganguli, M., Pandav, R., Johnston, J., Belle, S., & DeKosky, S. T.
- Venue
- Neurology
- Published
- 1998-10
- Volume
- 51
- Issue
- 4
- Pages
- 1000-1008
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1983814429
- Cited by
- 258
- References
- 0
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- closed
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