Clinical development of curcumin in neurodegenerative disease

Hu, Shuxin; Maiti, Panchanan; Ma, Qiulan; Zuo, Xiaohong; Jones, Mychica R; Cole, Greg M; Frautschy, Sally A

doi:10.1586/14737175.2015.1044981

Cited by 179Curcumin's Biomedical ApplicationsAlzheimer's disease research and treatmentsMedicinal Plants and Neuroprotection

Clinical development of curcumin in neurodegenerative disease

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Hu, Shuxin, Maiti, Panchanan, Ma, Qiulan, Zuo, Xiaohong, Jones, Mychica R, Cole, Greg M, Frautschy, Sally A·2015·Expert Review of Neurotherapeutics

DOI 10.1586/14737175.2015.1044981PMC PMC6800094

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Abstract

Curcumin, a polyphenolic antioxidant derived from the turmeric root has undergone extensive preclinical development, showing remarkable efficacy in wound repair, cancer and inflammatory disorders. This review addresses the rationale for its use in neurodegenerative disease, particularly Alzheimer's disease. Curcumin is a pleiotropic molecule, which not only directly binds to and limits aggregation of the β-sheet conformations of amyloid characteristic of many neurodegenerative diseases but also restores homeostasis of the inflammatory system, boosts the heat shock system to enhance clearance of toxic aggregates, scavenges free radicals, chelates iron and induces anti-oxidant response elements. Although curcumin corrects dysregulation of multiple pathways, it may exert many effects via a few molecular targets. Pharmaceutical development of natural compounds like curcumin and synthetic derivatives have strong scientific rationale, but will require overcoming various hurdles including; high cost of trials, concern about profitability and misconceptions about drug specificity, stability, and bioavailability.

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In two phase II trials in patients with AD, curcumin had no effect on cognition or CSF biomarkers.
“In two phase II trials151,152 in patients with AD, curcumin had no effect on cognition or CSF biomarkers149, and a third study in patients with MCI was terminated153.”
From Tau-targeting therapies for Alzheimer disease (2018) · cites this paper as [149]

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Soudamini, K. K., Unnikrishnan, M. C., Soni, K. B., & Kuttan, R. (1992) · PubMed · Cited by 120 · see citing works
Inhibition of Protease-Resistant Prion Protein Accumulation In Vitro by Curcumin
Caughey, B. W., Raymond, L. D., Raymond, G. J., Maxson, L., Silveira, J. R., & Baron, G. S. (2003) · Journal of Virology · doi:10.1128/jvi.77.9.5499-5502.2003 · Cited by 119 · see citing works
Curcumin mediates presenilin-1 activity to reduce β-amyloid production in a model of Alzheimer’s disease
Zhang, X., Hongmei, Z., Lu, S. Q., & Li, Y. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70629-6 · Cited by 116 · see citing works
Effects of turmeric on Alzheimer′s disease with behavioral and psychological symptoms of dementia
Hishikawa, N., Takahashi, Y., Amakusa, Y., Tanno, Y., Tuji, Y., Niwa, H., Murakami, N., & Krishna, U. (2012) · AYU (An International Quarterly Journal of Research in Ayurveda) · doi:10.4103/0974-8520.110524 · Cited by 115 · see citing works
Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: Blockage by curcumin
Lin, R., Chen, X., Li, W., Han, Y., Liu, P., & Pi, R. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.05.070 · Cited by 114 · see citing works
A broadly neuroprotective derivative of curcumin
Liu, Y., Dargusch, R., Maher, P. A., & Schubert, D. A. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05236.x · Cited by 113 · see citing works
Curcumin Attenuates Aluminum-Induced Oxidative Stress and Mitochondrial Dysfunction in Rat Brain
Sood, P. K., Nahar, U., & Nehru, B. (2011) · Neurotoxicity Research · doi:10.1007/s12640-011-9249-8 · Cited by 100 · see citing works
Ibuprofen Suppresses Interleukin-1β Induction of Pro-Amyloidogenic α1-Antichymotrypsin to Ameliorate β-Amyloid (Aβ) Pathology in Alzheimer's Models
Morihara, T., Teter, B., Yang, F., Lim, G. P., Boudinot, S. G., Boudinot, F. D., Frautschy, S. A., & Cole, G. M. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300668 · Cited by 94 · see citing works
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Tau-directed drug discovery for alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors
Brunden, K. R., Ballatore, C., Crowe, A., Smith, Lee, V. M.-Y., & Trojanowski, J. Q. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2009.08.031 · Cited by 93 · see citing works
Neuroimaging and APOE Genotype: A Systematic Qualitative Review
Cherbuin, N., Leach, L., Christensen, H. M., & Anstey, K. J. (2007) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000109150 · Cited by 91 · see citing works
Natural substances and Alzheimer's disease: From preclinical studies to evidence based medicine
Mancuso, C., Siciliano, R., Barone, E., & Preziosi, P. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.09.004 · Cited by 88 · see citing works
Safety assessment of a solid lipid curcumin particle preparation: Acute and subchronic toxicity studies
Dadhaniya, P., Patel, C. D., Muchhara, J., Bhadja, N. D., Mathuria, N., Vachhani, K., & Soni, M. G. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.05.001 · Cited by 84 · see citing works
Specific Inhibition of NEIL-initiated Repair of Oxidized Base Damage in Human Genome by Copper and Iron
Hegde, M. L., Hegde, P. M., Holthauzen, L. M. F., Hazra, T. K., Rao, K. S. J., & MITRA, S. P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.126664 · Cited by 76 · see citing works
Neurohormetic phytochemicals: An evolutionary–bioenergetic perspective
Murugaiyah, V., & Mattson, M. P. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.03.009 · Cited by 71 · see citing works
Binding of Curcumin to Senile Plaques and Cerebral Amyloid Angiopathy in the Aged Brain of Various Animals and to Neurofibrillary Tangles in Alzheimer's Brain
Mutsuga, M., CHAMBERS, J. K., Uchida, K., Tei, M., MAKIBUCHI, T., 溝呂木達也, Takashima, A., & Nakayama, H. (2011) · Journal of Veterinary Medical Science · doi:10.1292/jvms.11-0307 · Cited by 71 · see citing works
Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice
Yanagisawa, D., Ibrahim, N. F., Taguchi, H., Morikawa, S., Hirao, K., Shirai, N., Sogabe, T., & Tooyama, I. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.041 · Cited by 71 · see citing works
Immunotherapy for Alzheimer’s disease
Wilkinson, D. (2005) · CRC Press eBooks · doi:10.1201/b13935-7 · Cited by 65 · see citing works
NTP Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component 79%-85% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies).
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Attenuation of hematoma size and neurological injury with curcumin following intracerebral hemorrhage in mice
King, M. D., McCracken, D. J., Wade, F. M., Meiler, S. E. L., Alleyne, C. H., & Dhandapani, K. M. (2011) · Journal of neurosurgery · doi:10.3171/2011.2.jns10784 · Cited by 60 · see citing works
Curcumin Labeling of Neuronal Fibrillar Tau Inclusions in Human Brain Samples
Mohorko, N., Repovš, G., Popović, M., Kovács, G. G., & Bresjanac, M. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181d709eb · Cited by 58 · see citing works
Enhanced Glutathione Efflux from Astrocytes in Culture by Low Extracellular Ca2+ and Curcumin
Stridh, M. H., Corrêa, F., Nodin, C., Weber, S. G., Blomstrand, F., Nilsson, M., & Sandberg, M. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0179-2 · Cited by 56 · see citing works
The effect of curcumin on glutathione-linked enzymes in K562 human leukemia cells
Singhal, S. S., Awasthi, S., Pandya, U., Piper, J. T., Saini, M. K., Cheng, J.-Z., & Awasthi, Y. C. (1999) · Toxicology Letters · doi:10.1016/s0378-4274(99)00124-1 · Cited by 50 · see citing works
Astrocyte Overexpression of Heme Oxygenase-1 Improves Outcome After Intracerebral Hemorrhage
Chen‐Roetling, J., Song, W., Schipper, H. M., Regan, C. S., & Regan, R. F. (2015) · Stroke · doi:10.1161/strokeaha.115.008686 · Cited by 50 · see citing works
Insulin resistance in Alzheimer disease: Is heme oxygenase-1 an Achille's heel?
Barone, E., & Butterfield, D. A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.02.013 · Cited by 30 · see citing works
Risk factors of dementia in North India: a case–control study
Tripathi, M., Vibha, D., Gupta, P. K., Bhatia, R., Srivastava, M. V. P., Vivekanandhan, S., Singh, M. B., Prasad, K., Dergalust, S., & Mendez, M. F. (2011) · Aging & Mental Health · doi:10.1080/13607863.2011.583632 · Cited by 27 · see citing works
O3‐13‐01: RETINAL AMYLOID FLUORESCENCE IMAGING PREDICTS CEREBRAL AMYLOID BURDEN AND ALZHEIMER'S DISEASE
Frost, S. M., Kanagasingam, Y., Macaulay, L. S., Koronyo‐Hamaoui, M., Koronyo, Y., Biggs, D., Verdooner, S. R., Black, K. L., Taddei, K., Shah, T. M., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.04.341 · Cited by 25 · see citing works
P4‐026: Curcumin Improves Tau‐mediated Neuronal Dysfunction in Nematode
Miyasaka, T., Yoshimura, S., Saka, A., Shinzaki, Y., Yoshina, S., Kage‐Nakadai, E., Mitani, S., & Ihara, Y. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.08.086 · Cited by 3 · see citing works

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The Essential Medicinal Chemistry of Curcumin
Nelson, K. M., Dahlin, J. L., Bisson, J., Graham, J., Pauli, G. F., & Walters, M. A. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00975 · Cited by 1,956 · see citing works
Tau-targeting therapies for Alzheimer disease
Congdon, E. E., & Sigurdsson, E. M. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0013-z · Cited by 1,113 · see citing works
Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments
Maiti, P., Manna, J., & Dunbar, G. L. (2017) · Translational Neurodegeneration · doi:10.1186/s40035-017-0099-z · Cited by 534 · see citing works
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Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives
Xu, X., Meng, X., Li, S., Gan, R., Li, Y., & Li, H. (2018) · Nutrients · doi:10.3390/nu10101553 · Cited by 359 · see citing works
Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial
Small, G. W., Siddarth, P., Li, Z., Miller, K. J., Ercoli, L. M., Emerson, N. D., Martinez, J., Wong, K. P., Liu, J., Merrill, D. A., et al. (2017) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2017.10.010 · Cited by 357 · see citing works
Treatment Options for Motor and Non-Motor Symptoms of Parkinson’s Disease
Church, F. (2021) · Biomolecules · doi:10.3390/biom11040612 · Cited by 291 · see citing works
Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases
Sairazi, N. S. M., & Sirajudeen, K. N. S. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/6565396 · Cited by 250 · see citing works
Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease
Zhang, K., Chen, M., Du, Z.-Y., Zheng, X., Li, D., & Zhou, R. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.230303 · Cited by 236 · see citing works
Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases
Maiti, P., & Dunbar, G. L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061637 · Cited by 236 · see citing works
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Development of protein-polysaccharide-surfactant ternary complex particles as delivery vehicles for curcumin
Dai, L., Wei, Y., Sun, C., Mao, L., McClements, D. J., & Gao, Y. (2018) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2018.06.052 · Cited by 219 · see citing works
Benefits of curcumin in brain disorders
Bhat, A., Mahalakshmi, A. M., Ray, B., Tuladhar, S., Hediyal, T. A., Manthiannem, E., Jagadeeswari, P., Chandra, R., Chidambaram, S. B., & Sakharkar, M. K. (2019) · BioFactors · doi:10.1002/biof.1533 · Cited by 202 · see citing works
Curcumin Attenuates Amyloid-β Aggregate Toxicity and Modulates Amyloid-β Aggregation Pathway
Thapa, A., Jett, S. D., & Chi, E. Y. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00214 · Cited by 185 · see citing works
Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges
Rahman, M. H., Bajgai, J., Fadriquela, A., Sharma, S., Trinh, T. T., Akter, R., Jeong, Y. J., Goh, S. H., Kim, C.-S., & Lee, K.-J. (2021) · Molecules · doi:10.3390/molecules26175327 · Cited by 182 · see citing works
Nanoformulations of Herbal Extracts in Treatment of Neurodegenerative Disorders
Moradi, S. Z., Momtaz, S., Bayrami, Z., Farzaei, M. H., & Abdollahi, M. R. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00238 · Cited by 181 · see citing works
Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases
Momtazi‐Borojeni, A. A., Derosa, G., Maffioli, P., Banach, M., & Sahebkar, A. (2016) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-016-0202-7 · Cited by 179 · see citing works
Curcumin, Hormesis and the Nervous System
Scuto, M. C., Mancuso, C., Tomasello, B., Ontario, M. L., Cavallaro, A. S., Frasca, F., Maiolino, L., Salinaro, A. T., Calabrese, E. J., & Calabrese, V. (2019) · Nutrients · doi:10.3390/nu11102417 · Cited by 155 · see citing works
Curcumin attenuates inflammatory response and cognitive deficits in experimental model of chronic epilepsy
Kaur, H., Patro, I. K., Tikoo, K., & Sandhir, R. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.07.009 · Cited by 126 · see citing works
Molecular regulation of dendritic spine dynamics and their potential impact on synaptic plasticity and neurological diseases
Maiti, P., Manna, J., Ilavazhagan, G., Rossignol, J., & Dunbar, G. L. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.09.020 · Cited by 118 · see citing works
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Eriodictyol Attenuates LPS-Induced Neuroinflammation, Amyloidogenesis, and Cognitive Impairments via the Inhibition of NF-κB in Male C57BL/6J Mice and BV2 Microglial Cells
He, P., Yan, S., Zheng, J., Gao, Y., Zhang, S., Liu, Z., Liu, X., & Xiao, C. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03731 · Cited by 120 · see citing works
Protective Effects of Curcumin Against Ischemia-Reperfusion Injury in the Nervous System
Bavarsad, K., Barreto, G. E., Hadjzadeh, M., & Sahebkar, A. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1169-7 · Cited by 115 · see citing works
Curcumin and Solid Lipid Curcumin Particles Induce Autophagy, but Inhibit Mitophagy and the PI3K-Akt/mTOR Pathway in Cultured Glioblastoma Cells
Maiti, P., Scott, J., Sengupta, D., Gharaibeh, A., & Dunbar, G. L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020399 · Cited by 115 · see citing works
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Curcumin as a therapeutic agent for blocking NF-κB activation in ulcerative colitis
Wang, Y., Tang, Q.-C., Duan, P., & Yang, L. (2018) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2018.1469145 · Cited by 113 · see citing works
Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview
Libro, R., Giacoppo, S., Soundara Rajan, T., Bramanti, P., & Mazzon, E. (2016) · Molecules · doi:10.3390/molecules21040518 · Cited by 107 · see citing works
The Pathology of Parkinson’s Disease and Potential Benefit of Dietary Polyphenols
Aryal, S., Skinner, T., Bridges, B., & Weber, J. T. (2020) · Molecules · doi:10.3390/molecules25194382 · Cited by 109 · see citing works
Characterization of curcumin loaded gliadin-lecithin composite nanoparticles fabricated by antisolvent precipitation in different blending sequences
Yang, S., Dai, L., Sun, C., & Gao, Y. (2018) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2018.07.015 · Cited by 103 · see citing works
Monocarbonyl Curcumin-Based Molecular Hybrids as Potent Antibacterial Agents
Singh, A., Singh, J. V., Rana, A., Bhagat, K., Gulati, H. K., Kumar, R., Salwan, R., Bhagat, K., Kaur, G., Singh, N., et al. (2019) · ACS Omega · doi:10.1021/acsomega.9b01109 · Cited by 100 · see citing works
Curcumin confers neuroprotection against alcohol-induced hippocampal neurodegeneration via CREB-BDNF pathway in rats
Motaghinejad, M., Motevalian, M., Fatima, S., Hashemi, H., & Gholami, M. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.12.020 · Cited by 98 · see citing works
Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies
Zhang, X., Wang, J., Zhang, Z., & Ye, K. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00429-6 · Cited by 106 · see citing works
Effects of Curcumin on Microglial Cells
Ghasemi, F., Bagheri, H., Barreto, G. E., Read, M. I., & Sahebkar, A. (2019) · Neurotoxicity Research · doi:10.1007/s12640-019-00030-0 · Cited by 97 · see citing works
Dietary Modulation of Oxidative Stress in Alzheimer’s Disease
Thapa, A., & Carroll, N. J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071583 · Cited by 94 · see citing works
Effects of Curcumin on Vessel Formation Insight into the Pro- and Antiangiogenesis of Curcumin
Wang, T., & Chen, J. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/1390795 · Cited by 91 · see citing works
RETRACTED ARTICLE: Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s disease
Maiti, P., Paladugu, L., & Dunbar, G. L. (2018) · BMC Neuroscience · doi:10.1186/s12868-018-0406-3 · Cited by 87 · see citing works
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Recent Findings in Alzheimer Disease and Nutrition Focusing on Epigenetics
Athanasopoulos, D., Karagiannis, G., & Tsolaki, M. (2016) · Advances in Nutrition · doi:10.3945/an.116.012229 · Cited by 81 · see citing works
A comparative study of dietary curcumin, nanocurcumin, and other classical amyloid-binding dyes for labeling and imaging of amyloid plaques in brain tissue of 5×-familial Alzheimer’s disease mice
Maiti, P., Hall, T. C., Paladugu, L., Kolli, N., Learman, C. R., Rossignol, J., & Dunbar, G. L. (2016) · Histochemistry and Cell Biology · doi:10.1007/s00418-016-1464-1 · Cited by 75 · see citing works
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Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways.
Kandezi, N., Mohammadi, M., Ghaffari, M., Gholami, M., Motaghinejad, M., & Safari, S. (2020) · PubMed Central · doi:10.22088/ijmcm.bums.9.1.1 · Cited by 67 · see citing works
Inhibition of Aβ aggregates in Alzheimer’s disease by epigallocatechin and epicatechin-3-gallate from green tea
Chen, T., Yang, Y., Zhu, S., Lu, Y., Zhu, L., Wang, Y., & Wang, X. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104382 · Cited by 64 · see citing works
A novel curcumin derivative for the treatment of diabetic neuropathy
Daugherty, D. J., Marquez, A., Calcutt, N. A., & Schubert, D. A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.007 · Cited by 64 · see citing works
Effects of curcumin on neurological diseases: focus on astrocytes
Eghbaliferiz, S., Farhadi, F., Barreto, G. E., Majeed, M. A., & Sahebkar, A. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00112-3 · Cited by 63 · see citing works
A Combination of Resveratrol and Curcumin is Effective Against Aluminum Chloride-Induced Neuroinflammation in Rats
Zaky, A., Bassiouny, A. R., Farghaly, M., & Elsabaa, B. M. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161115 · Cited by 63 · see citing works
Polyphenols and neurodegenerative diseases: focus on neuronal regeneration
Moradi, S. Z., Jalili, F., Farhadian, N., Joshi, T., Wang, M., Zou, L., Cao, H., Farzaei, M. H., & Xiao, J. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1865870 · Cited by 62 · see citing works
Soluble endogenous oligomeric α-synuclein species in neurodegenerative diseases: Expression, spreading, and cross-talk
Kayed, R., Dettmer, U., & Lesné, S. (2020) · Journal of Parkinson s Disease · doi:10.3233/jpd-201965 · Cited by 62 · see citing works
JAK2/STAT3 as a new potential target to manage neurodegenerative diseases: An interactive review
Panda, S. P., Kesharwani, A., Datta, S., Prasanth, D., Panda, S. K., & Guru, A. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176490 · Cited by 60 · see citing works
Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders
Hung, W., Ho, C., & Pan, M. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900550 · Cited by 57 · see citing works
Oxidative Stress in Tauopathies: From Cause to Therapy
Bartolomé, F. B., Carro, E., & Alquézar, C. (2022) · Antioxidants · doi:10.3390/antiox11081421 · Cited by 57 · see citing works
Modulating disease-relevant tau oligomeric strains by small molecules
Cascio, F. L., García, S., Montalbano, M., Puangmalai, N., McAllen, S., Pace, A., Piccionello, A. P., & Kayed, R. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014630 · Cited by 54 · see citing works
Non-invasive optical imaging of retinal Aβ plaques using curcumin loaded polymeric micelles in APP swe /PS1 ΔE9 transgenic mice for the diagnosis of Alzheimer's disease
Chibhabha, F., Yang, Y., Ying, K., Jia, F., Zhang, Q., Ullah, S., Liang, Z., Xie, M., & Li, F. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01101k · Cited by 52 · see citing works
Diagnosis and Treatment of Alzheimer’s Disease:
Bomasang-Layno, E., & Bronsther, R. (2021) · Delaware Journal of Public Health · doi:10.32481/djph.2021.09.009 · Cited by 52 · see citing works
Curcumin-like compounds designed to modify amyloid beta peptide aggregation patterns
Battisti, A., Piccionello, A. P., Sgarbossa, A., Vilasi, S., Ricci, C., Ghetti, F., Spinozzi, F., Marino, A., Giacalone, V., Martorana, A., et al. (2017) · RSC Advances · doi:10.1039/c7ra05300b · Cited by 49 · see citing works
Ginger and Turmeric Essential Oils for Weed Control and Food Crop Protection
Ibáñez, M. D., & Blázquez, M. A. (2019) · Plants · doi:10.3390/plants8030059 · Cited by 47 · see citing works
Curcumin dietary supplementation ameliorates disease phenotype in an animal model of Huntington’s disease.
Elifani, F., Amico, E., Pepe, G., Capocci, L., Castaldo, S., Rosa, P., Montano, E., Pollice, A., Madonna, M., Filosa, S., et al. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz247 · Cited by 45 · see citing works
Substantiation for the Use of Curcumin during the Development of Neurodegeneration after Brain Ischemia
Ułamek-Kozioł, M., Czuczwar, S. J., Januszewski, S., & Pluta, R. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020517 · Cited by 43 · see citing works
RETRACTED ARTICLE: Preservation of dendritic spine morphology and postsynaptic signaling markers after treatment with solid lipid curcumin particles in the 5xFAD mouse model of Alzheimer’s amyloidosis
Maiti, P., Bowers, Z., Bourcier, A., Morse, J., & Dunbar, G. L. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00769-9 · Cited by 44 · see citing works
Self-citation
Retracted
Geroneuroprotectors: Effective Geroprotectors for the Brain
Schubert, D. A., Currais, A. J. M., Goldberg, J., Finley, K. D., Petrascheck, M., & Maher, P. A. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.09.008 · Cited by 43 · see citing works
Significance of Antioxidants in the Treatment and Prevention of Neurodegenerative Diseases
Fadaka, A. O., Ajiboye, B. O., Adewale, I., Ojo, O. A., Oyinloye, B. E., & Okesola, M. A. (2019) · The Journal of Phytopharmacology · doi:10.31254/phyto.2019.8210 · Cited by 46 · see citing works
Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases
Momtaz, S., Memariani, Z., El‐Senduny, F. F., Sanadgol, N., Golab, F., Katebi, M., Abdolghaffari, A. H., Farzaei, M. H., & Abdollahi, M. R. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00361 · Cited by 43 · see citing works
Effects of Curcumin on Lipid Membranes: an EPR Spin-label Study
Duda, M., Cygan, K., & Wiśniewska-Becker, A. (2020) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-020-00906-5 · Cited by 40 · see citing works
Post-Ischemic Brain Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Possible Therapeutic Role of Curcumin
Pluta, R. M., Furmaga-Jabłońska, W., Januszewski, S., & Czuczwar, S. J. (2022) · Nutrients · doi:10.3390/nu14020248 · Cited by 38 · see citing works
The Golden Spice Turmeric (Curcuma longa) and Its Feasible Benefits in Prospering Human Health—A Review
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Authors: Hu, S., Maiti, P., Ma, Q., Zuo, X., Jones, M. R., Cole, G. M., & Frautschy, S. A.
Affiliations: VA Greater Los Angeles Healthcare System (US)
University of California, Los Angeles (US)
Corresponding author: Frautschy, Sally A
ORCID: Hu, Shuxin
Maiti, Panchanan
Jones, Mychica R
Frautschy, Sally A
Venue: Expert Review of Neurotherapeutics
Publisher: Informa UK Limited
Published: 2015-06-02
Volume: 15
Issue: 6
Pages: 629-637
ISSN: 1473-7175 (ISSN-L)
1744-8360
DOI: 10.1586/14737175.2015.1044981
PMC: PMC6800094
OpenAlex: W1877722768
Cited by: 179
References: 101
Citations by year: 2026: 6 · 2025: 11 · 2024: 18 · 2023: 16 · 2022: 12 · 2021: 19 · 2020: 26 · 2019: 17 · 2018: 20 · 2017: 20 · 2016: 11 · 2015: 3
FWCI: 1.28
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Expert Review of Neurotherapeutics (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs (I01 RX000669, I01 BX001257)
National Institute on Aging (U01AG028583, R01AG021975)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords: curcumin, neurodegenerative diseases, Alzheimer's disease, amyloid fibril formation, anti-inflammatory activity, heat shock response, antioxidant activity, iron chelation, drug development, bioavailability, natural product derivatives
MeSH terms: Anti-Inflammatory Agents, Non-Steroidal, Brain, Curcumin, Humans, Models, Biological, Retina, Amyloid beta-Peptides, tau Proteins, Neurodegenerative Diseases

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