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Ten-year incidence of dementia in a rural elderly US community population: The MoVIES Project
Abstract
Objective To determine incidence rates by age, sex, and education of overall dementia and probable/ possible AD in a largely rural community. Methods Ten-year prospective study of a randomly selected community sample aged 65+; biennial cognitive screening followed by standardized clinical evaluation. Incidence rates were estimated for overall dementia (Diagnostic and Statistical Manual of Mental Disorders, 3rd ed., revised, criteria and Clinical Dementia Rating [CDR]) and for probable/possible AD (National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria). Results The cohort consisted of 1,298 individuals free of dementia at study entry. Among these, 199 incident (new) cases of overall (all-cause) dementia with CDR stage > or = 0.5, including 110 with CDR > or = 1, were detected during follow-up. Among the incident cases, 153 (76.9%) had probable/ possible AD. Age-specific incidence rates are reported for all dementia and for probable/possible AD, by sex and CDR stage. Among all-cause dementias with CDR = 0.5, controlling for age and education, men had a higher incidence rate than women. In the same group, those with less than high school education had significantly higher incidence rates than those with more education. Rates did not vary significantly by sex or education for probable/possible AD or for dementia with CDR > or = 1. Conclusions Incidence rates of all dementias and of AD increased wit…
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“Since then, this variant has been examined in additional AD case-control samples [11–13]”
From Investigation of the independent role of a rare APOE variant (L28P; APOE*4Pittsburgh) in late-onset Alzheimer disease (2023) · cites this paper as [12]
In the citing paper
“The original association study implicating L28P with LOAD risk was carried out in a relatively small sample size.”
From Investigation of the independent role of a rare APOE variant (L28P; APOE*4Pittsburgh) in late-onset Alzheimer disease (2023) · cites this paper as [12]
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Self-citationIncidence of dementia and subtypes: A cohort study in four regions in China
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Self-citationBasu, R., Dodge, H. H., Stoehr, G. P., & Ganguli, M. (2003) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200303000-00011 · Cited by 69
Self-citationSubjective Cognitive Complaints of Older Adults at the Population Level
Snitz, B. E., Yu, L., Crane, P. K., Chang, C. H., Hughes, T. F., & Ganguli, M. (2011) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3182420bdf · Cited by 71
Self-citationCohort Effects in Age-Associated Cognitive Trajectories
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Self-citationMielke, M. M. (2019) · The Journal of Applied Laboratory Medicine · doi:10.1373/jalm.2019.030023 · Cited by 67
Terminal decline and practice effects in older adults without dementia
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Self-citationDementia in Taiwan: past, present, and future.
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Membrane-Mediated Neuroprotection by Curcumin from Amyloid-β-Peptide-Induced Toxicity
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Self-citationPrevalence of Dementia and Main Subtypes in Rural Northern China
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Blood Pressure and Cognitive Impairment in India and the United States
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Self-citationAntioxidants for the treatment of mild cognitive impairment
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Prevalence of cognitive disorders differs as a function of age in HIV virus infection
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DeCarli, C. S. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-129004 · Cited by 50
Is There Any Relation Between Pseudoexfoliation Syndrome and Alzheimer’s Type Dementia?
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Designing a large prevention trial: statistical issues
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Metadata
- Authors
- Ganguli, M., Dodge, H. H., Chen, P., Belle, S., & DeKosky, S. T.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Neurology
- Published
- 2000-03-14
- Volume
- 54
- Issue
- 5
- Pages
- 1109-1116
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1969541608
- Cited by
- 196
- References
- 39
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 12 · 2021: 4 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 1 · 2016: 8 · 2015: 6 · 2014: 2 · 2013: 7 · 2012: 10
- FWCI
- 6.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 05-133, AG 07562, P50AG005133, R01AG007562, AG00181)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- dementia incidence, Alzheimer's disease, rural elderly, sex differences, educational attainment, age-specific incidence, Clinical Dementia Rating, probable Alzheimer's disease, community-dwelling older adults, sex differences in dementia
- MeSH terms
- Aged, Aged, 80 and over, Dementia, Female, Humans, Male, Pennsylvania, Rural Population, Time Factors, United States, Incidence
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