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Cited by 234Parkinson's Disease Mechanisms and TreatmentsCoffee research and impactsDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Smoking, alcohol, and coffee consumption preceding Parkinson’s disease: A case-control study

Benedetti, M.D., Bower, J.H., Maraganore, D.M., McDonnell, S.K., Peterson, B.J., Ahlskog, J.E., Schaid, D.J., Rocca, W.A.·2000·Neurology
DOI 10.1212/wnl.55.9.1350
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Abstract

OBJECTIVE: To study the association of PD with preceding smoking, alcohol, and coffee consumption using a case-control design. METHODS: The authors used the medical records linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, during the years 1976 to 1995. Each incident case was matched by age (+/-1 year) and sex to a general population control subject. The authors reviewed the complete medical records of cases and control subjects to abstract exposure information. RESULTS: For coffee consumption, the authors found an OR of 0.35 (95% CI = 0.16 to 0.78, p = 0.01), a dose-effect trend (p = 0.003), and a later age at PD onset in cases who drank coffee compared with those who never did (median 72 versus 64 years; p = 0.0002). The inverse association with coffee remained significant after adjustment for education, smoking, and alcohol drinking and was restricted to PD cases with onset at age <72 years and to men. The OR for cigarette smoking was 0.69 (95% CI = 0.45 to 1.08, p = 0.1). The authors found no association between PD and alcohol consumption. Extreme or unusual behaviors such as tobacco chewing or snuff use and a diagnosis of alcoholism were significantly more common in control subjects than cases. CONCLUSIONS: These findings suggest an inverse association between coffee drinking and PD; however, this association does not imply that coffee has a direct protective effect against PD. Alternative explanations for the association should be considered.

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Research works printed but not linked: 6

  1. Nelson LM, Van Den Eeden SK, Tanner CM, et al. Association of alcohol and tobacco consumption with Parkinson’s disease: a population-based study. Neurology . 1999; 52 (suppl 2): A538–A539. Abstract.
  2. Last JM. A dictionary of epidemiology. 3rd ed. Abramson JH Friedman GD Porta M Spasoff RA Thuriaux M eds. New York: Oxford University Press 1995.
  3. Schlesselman JJ Stolley PD. Case-control studies. Design conduct analysis. New York: Oxford University Press 1982.
  4. Tukey JW. Exploratory data analysis. Reading: Addison-Wesley 1997.
  5. Eldridge R Rocca WA. Parkinson’s disease. In: RA King Rotter JI Motulsky AG eds. The genetic basis of common diseases. New York: Oxford University Press 1992.
  6. Hardman JG Gilman AG Limbird LE. Goodman & Gilman’s the pharmacological basis of therapeutics. 9th ed. New York: McGraw-Hill 1996.

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Metadata

Authors
Benedetti, M. D., Bower, J. H., Maraganore, D. M., McDonnell, S. K., Peterson, B. J., Ahlskog, J. E., Schaid, D. J., & Rocca, W. A.
Affiliations
Mayo Clinic (US)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2000-11-14
Volume
55
Issue
9
Pages
1350-1358
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.55.9.1350
OpenAlex
W2172189733
Cited by
234
References
34
Citations by year
2026: 2 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 10 · 2020: 5 · 2019: 5 · 2018: 9 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 7 · 2013: 7 · 2012: 10
FWCI
5.25
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke (R01NS033978, NS33978)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR030582, AR30582)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Parkinson's disease, coffee consumption, cigarette smoking, alcohol consumption, risk factors, age of onset, tobacco chewing, snuff use, alcoholism, Rochester Epidemiology Project, Rochester, Minnesota
MeSH terms
Adult, Aged, Alcohol Drinking, Coffee, Female, Humans, Male, Middle Aged, Minnesota, Parkinson Disease, Smoking, Case-Control Studies

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