Principles of recovery from traumatic brain injury: Reorganization of functional networks
Abstract
Recovery after brain injury is an excellent platform to study the mechanism underlying brain plasticity, the reorganization of networks. Do complex network measures capture the physiological and cognitive alterations that occurred after a traumatic brain injury and its recovery? Patients as well as control subjects underwent resting-state MEG recording following injury and after neurorehabilitation. Next, network measures such as network strength, path length, efficiency, clustering and energetic cost were calculated. We show that these parameters restore, in many cases, to control ones after recovery, specifically in delta and alpha bands, and we design a model that gives some hints about how the functional networks modify their weights in the recovery process. Positive correlations between complex network measures and some of the general index of the WAIS-III test were found: changes in delta-based path-length and those in Performance IQ score, and alpha-based normalized global efficiency and Perceptual Organization Index. These results indicate that: 1) the principle of recovery depends on the spectral band, 2) the structure of the functional networks evolves in parallel to brain recovery with correlations with neuropsychological scales, and 3) energetic cost reveals an optimal principle of recovery.
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Recovery of network measures correlated positively with neurocognitive recovery.
“Recovery of network measures also correlated positively with neurocognitive recovery”
From Graph theory analysis of complex brain networks: new concepts in brain mapping applied to neurosurgery (2016) · cites this paper as [24]
Reorganization of functional networks occurs during neuro-rehabilitation.
“Reorganization of functional networks has been found to occur during neuro-rehabilitation.”
From Graph theory analysis of complex brain networks: new concepts in brain mapping applied to neurosurgery (2016) · cites this paper as [24]
Baseline measurements soon after TBI reproduced patterns of network disruption (increased path length and increased connectivity); during recovery, these measures returned to normal levels.
“Baseline measurements soon after TBI reproduced patterns of network disruption identified in previous studies (including increased path length and increased connectivity); during recovery, these measures returned to normal levels.24”
From Graph theory analysis of complex brain networks: new concepts in brain mapping applied to neurosurgery (2016) · cites this paper as [24]
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- Authors
- Castellanos, N. P., Leyva, I., Buldú, J. M., Bajo, R., Paúl, N., Cuesta, P., Ordóñez, V. E., Pascua, C. L., Boccaletti, S., Maestú, F., & del-Pozo, F.
- Affiliations
- Universidad Complutense de Madrid (ES)
- Universidad Rey Juan Carlos (ES)
- Institute for Complex Systems (IT)
- Corresponding author
- Castellanos, Nazareth P.
- Leyva, Inmaculada
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 55
- Issue
- 3
- Pages
- 1189-1199
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2139755434
- Cited by
- 96
- References
- 75
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 9 · 2021: 3 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 8 · 2016: 9 · 2015: 12 · 2014: 9 · 2013: 11 · 2012: 7
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- MADRI.B
- Obra Social CajaMadrid
- MAPFRE 2008
- IMSERSO (07-2008)
- Spanish Ministry of Science and Technology (FIS2009-07072)
- Community of Madrid
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- traumatic brain injury, recovery, neuroplasticity, resting-state MEG, neurorehabilitation, network efficiency, path length, energetic cost, neuropsychological correlates, performance IQ, perceptual organization
- MeSH terms
- Adolescent, Adult, Algorithms, Alpha Rhythm, Brain, Brain Injuries, Data Interpretation, Statistical, Delta Rhythm, Energy Metabolism, Female, Humans, Intelligence Tests, Male, Middle Aged, Nerve Net, Neuropsychological Tests, Magnetoencephalography, Cluster Analysis, Databases, Factual, Recovery of Function, Young Adult
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