Cited by 134Parkinson's Disease Mechanisms and TreatmentsNerve injury and regenerationNuclear Receptors and Signaling

Effects of Brain-derived Neurotrophic Factor on 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in Monkeys

Tsukahara, Tetsuya, Takeda, Makoto, Shimohama, Shun, Ohara, Osamu, Hashimoto, Nobuo·1995·Neurosurgery

Abstract

The effects of intrathecal infusion of brain-derived neurotrophic factor (BDNF) were examined in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian model in monkeys. Nine Japanese monkeys were divided randomly into three groups, an untreated control (n = 3), a BDNF group (n = 3), and a non-BDNF group (n = 3). Animals in the BDNF group received continuous intrathecal infusion of 10 ml of cell culture medium containing 10 micrograms of BDNF protein; the non-BDNF group received intrathecal infusion of the same culture medium without BDNF. To induce parkinsonian syndromes, a total of 1 mg/kg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine was administered intravenously to each monkey in both the BDNF and non-BDNF groups. The neurological signs in the monkeys were monitored for 2 weeks and were scored according to the monkey parkinsonism rating scale; histological changes in the substantia nigra were evaluated after the 2-week observation period. The BDNF-treated animals remained asymptomatic during the 1st week and showed mild parkinsonism during the 2nd week, whereas the non-BDNF group showed typical parkinsonian syndrome during the 1st week, with deterioration in the 2nd week. Histological damage in the substantia nigra correlated well with the clinical features. Severe neuronal cell loss in the substantia nigra was observed in animals with severe parkinsonism (those in the non-BDNF group), whereas significantly less damage was observed in this region in the BDNF group.(ABSTRACT TRUNCATED AT 250 WORDS)

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Registry

Crossref · 10.1227/00006123-199510000-00018

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59 of 59 references verified0 citation errors · 0 not checkable

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  • In animal models of Parkinson's disease, BDNF enhances the survival of dopaminergic neurons.

    “In animal models of Parkinson’s disease (PD), BDNF enhances the survival of dopaminergic neurons, improves dopaminergic neurotransmission and motor performance.”
  • In monkeys, BDNF treatment resulted in significantly less severe symptoms of Parkinson's disease.

    “In the case of alternations in behavior, the studies on monkeys revealed significantly less severe symptoms of PD in animals treated with BDNF [89].”
  • In the vast majority of studies with BDNF administration before induction of parkinsonism, the results revealed at least partial prevention of neuronal cell loss.

    “In the vast majority of studies with BDNF administration before induction of parkinsonism, the research results revealed at least partial prevention of neuronal cell loss [89,90,92,93,99,101].”

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Authors
Tsukahara, T., Takeda, M., Shimohama, S., Ohara, O., & Hashimoto, N.
Affiliations
  • National Cerebral and Cardiovascular Center (JP)
  • Kyoto University (JP)
  • Shionogi (Japan) (JP)
Venue
Neurosurgery
Published
1995-10-01
Volume
37
Issue
4
Pages
733-741
ISSN
  • 0148-396X (ISSN-L)
  • 1524-4040
OpenAlex
W1976999555
Cited by
134
References
60
Citations by year
2026: 1 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 5 · 2020: 8 · 2019: 8 · 2018: 7 · 2016: 9 · 2015: 3 · 2014: 8 · 2013: 6 · 2012: 10
FWCI
1.83
Type
journal article
Language
en
Open access
closed
Locations
  • Neurosurgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
brain-derived neurotrophic factor, Parkinson's disease, MPTP-induced parkinsonism, intrathecal infusion, substantia nigra, neuronal loss, neuroprotection, monkey model
MeSH terms
Animals, Brain, Macaca, Nerve Degeneration, Nerve Growth Factors, Nerve Tissue Proteins, Neurologic Examination, Parkinson Disease, Secondary, Substantia Nigra, Tyrosine 3-Monooxygenase, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Brain-Derived Neurotrophic Factor

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