The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Kinesin light chain -independent function of the Kinesin heavy chain in cytoplasmic streaming and posterior localisation in the Drosophila oocyte
Abstract
Microtubules and the Kinesin heavy chain, the force-generating component of the plus end-directed microtubule motor Kinesin I are required for the localisation of oskar mRNA to the posterior pole of theDrosophila oocyte, an essential step in the determination of the anteroposterior axis. We show that the Kinesin heavy chain is also required for the posterior localisation of Dynein, and for all cytoplasmic movements within the oocyte. Furthermore, the KHC localises transiently to the posterior pole in an oskar mRNA-independent manner. Surprisingly, cytoplasmic streaming still occurs in kinesin light chain null mutants, and bothoskar mRNA and Dynein localise to the posterior pole. Thus, the Kinesin heavy chain can function independently of the light chain in the oocyte, indicating that it associates with its cargoes by a novel mechanism.
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Cites
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
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“In Drosophila, the asymmetries that specify the embryonic axes are established early during oogenesis in a process that requires the precise localisation of several transcripts (Riechmann and Ephrussi, 2001; van Eeden and St Johnston, 1999).”
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Kinesin׳s tail domain is an inhibitory regulator of the motor domain
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Light Chain– dependent Regulation of Kinesin's Interaction with Microtubules
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Kinesin Light Chains Are Essential for Axonal Transport in Drosophila
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Cargo binding and regulatory sites in the tail of fungal conventional kinesin
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Cited by
Molecular motors and mechanisms of directional transport in neurons
Hirokawa, N., & Takemura, R. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1624 · Cited by 834
Mechanisms of microtubule organization in differentiated animal cells
Akhmanova, A., & Kapitein, L. C. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00473-y · Cited by 233
Kinesin Assembly and Movement in Cells
Verhey, K. J., Kaul, N., & Soppina, V. (2011) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-042910-155310 · Cited by 231
JIP3 Activates Kinesin-1 Motility to Promote Axon Elongation
Watt, D., Dixit, R., & Cavalli, V. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.651885 · Cited by 46
Kinesin-1 is highly flexible and adopts an open conformation in the absence of cargo
(2026) · doi:10.1016/j.isci.2026.114875 · Cited by 5
Metadata
- Authors
- Palacios, I. M., & Johnston, D. S.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2002-12-01
- Volume
- 129
- Issue
- 23
- Pages
- 5473-5485
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1985687970
- Cited by
- 190
- References
- 14
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Palacios, I. M., & Johnston, D. S. (2002). Kinesin light chain -independent function of the Kinesin heavy chain in cytoplasmic streaming and posterior localisation in the Drosophila oocyte. Development. https://doi.org/10.1242/dev.00119
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