The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning
Open accessAbstract
Planar polarity decisions in the wing of Drosophila involve the assembly of asymmetric protein complexes containing the conserved receptor Frizzled. In this study, we analyse the role of the Van Gogh/strabismus gene in the formation of these complexes and cell polarisation. We find that the Strabismus protein becomes asymmetrically localised to the proximal edge of cells. In the absence of strabismusactivity, the planar polarity proteins Dishevelled and Prickle are mislocalised in the cell. We show that Strabismus binds directly to Dishevelled and Prickle and is able to recruit them to membranes. Furthermore,we demonstrate that the putative PDZ-binding motif at the C terminus of Strabismus is not required for its function. We propose a two-step model for assembly of Frizzledcontaining asymmetric protein complexes at cell boundaries. First, Strabismus acts together with Frizzled and the atypical cadherin Flamingo to mediate apicolateral recruitment of planar polarity proteins including Dishevelled and Prickle. In the second phase, Dishevelled and Prickle are required for these proteins to become asymmetrically distributed on the proximodistal axis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements
Jessen, J. R., Topczewski, J., Bingham, S., Sepich, D. S., Marlow, F., Chandrasekhar, A., & Solnica-Krezel, L. (2002) · Nature Cell Biology · doi:10.1038/ncb828 · Cited by 504
Kibar, Z., Vogan, K. J., Groulx, N., Justice, M. J., Underhill, D. A., & Gros, P. (2001) · Nature Genetics · doi:10.1038/90081 · Cited by 504
The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos
Park, M., & Moon, R. T. (2002) · Nature Cell Biology · doi:10.1038/ncb716 · Cited by 381
Cited by
Veeman, M. T., Axelrod, J. D., & Moon, R. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00266-1 · Cited by 1,359
Planar cell polarity in development and disease
Butler, M. T., & Wallingford, J. B. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.11 · Cited by 580
Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility
Seifert, J. R. K., & Mlodzik, M. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2042 · Cited by 513
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
Wallingford, J. B., & Habas, R. (2005) · Development · doi:10.1242/dev.02068 · Cited by 509
Montcouquiol, M., Sans, N., Huss, D., Kach, J., Dickman, J. D., Forge, A., Rachel, R. A., Copeland, N. G., Jenkins, N. A., Bogani, D., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4680-05.2006 · Cited by 322
The cell biology of planar cell polarity
Devenport, D. (2014) · Journal of Cell Biology · doi:10.1083/jcb.201408039 · Cited by 323
Essential role of non-canonical Wnt signalling in neural crest migration
De Calisto, J., Araya, C., Marchant, L., Riaz, C. F., & Mayor, R. (2005) · Development · doi:10.1242/dev.01857 · Cited by 304
Courbard, J.-R., Djiane, A., Wu, J., & Mlodzik, M. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.06.024 · Cited by 82
Intestinal tube formation in Caenorhabditis elegans requires vang-1 and egl-15 signaling
Hoffmann, M., Segbert, C., Helbig, G., & Bossinger, O. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.12.002 · Cited by 38
Metadata
- Authors
- Bastock, R., Strutt, H., & Strutt, D.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-07-01
- Volume
- 130
- Issue
- 13
- Pages
- 3007-3014
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2140883347
- Cited by
- 336
- References
- 3
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
