The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Selective loss of imprinting in the placenta following preimplantation development in culture
Abstract
Preimplantation development is a period of dynamic epigenetic change that begins with remodeling of egg and sperm genomes, and ends with implantation. During this time, parental-specific imprinting marks are maintained to direct appropriate imprinted gene expression. We previously demonstrated that H19 imprinting could be lost during preimplantation development under certain culture conditions. To define the lability of genomic imprints during this dynamic period and to determine whether loss of imprinting continues at later stages of development, imprinted gene expression and methylation were examined after in vitro preimplantation culture. Following culture in Whitten's medium, the normally silent paternal H19 allele was aberrantly expressed and undermethylated. However, only a subset of individual cultured blastocysts (∼65%) exhibited biallelic expression, while others maintained imprinted H19 expression. Loss of H19 imprinting persisted in mid-gestation conceptuses. Placental tissues displayed activation of the normally silent allele for H19, Ascl2, Snrpn, Peg3 and Xist while in the embryo proper imprinted expression for the most part was preserved. Loss of imprinted expression was associated with a decrease in methylation at the H19 and Snrpn imprinting control regions. These results indicate that tissues of trophectoderm origin are unable to restore genomic imprints and suggest that mechanisms that safeguard imprinting might be more robust in the embryo than in the placenta.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.
Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W., & Roder, J. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8424 · Cited by 2,329
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
Okano, M., Xie, S., & Li, E. (1998) · Nature Genetics · doi:10.1038/890 · Cited by 1,651
Completion of mouse embryogenesis requires both the maternal and paternal genomes
McGrath, J., & Solter, D. (1984) · Cell · doi:10.1016/0092-8674(84)90313-1 · Cited by 1,571
Dynamic Reprogramming of DNA Methylation in the Early Mouse Embryo
Santos, F., Hendrich, B., Reik, W., & Dean, W. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0501 · Cited by 1,212
Monk, M., Boubelik, M., & Lehnert, S. (1987) · Development · doi:10.1242/dev.99.3.371 · Cited by 1,094
DeBaun, M. R., Niemitz, E. L., & Feinberg, A. P. (2003) · The American Journal of Human Genetics · doi:10.1086/346031 · Cited by 916
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
Lei, H., Oh, S. P., Okano, M., Jüttermann, R., Goss, K. A., Jaenisch, R., & Li, E. (1996) · Development · doi:10.1242/dev.122.10.3195 · Cited by 816
Chen, T., Ueda, Y., Dodge, J. E., Wang, Z., & Li, E. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5594-5605.2003 · Cited by 751
Role of paternal and maternal genomes in mouse development
Barton, S. C., Surani, M. A. H., & Norris, M. L. (1984) · Nature · doi:10.1038/311374a0 · Cited by 724
Differential Effects of Culture on Imprinted H19 Expression in the Preimplantation Mouse Embryo1
Doherty, A. S., Mann, M. R. W., Tremblay, K. D., Bartolomei, M. S., & Schultz, R. M. (2000) · Biology of Reproduction · doi:10.1095/biolreprod62.6.1526 · Cited by 722
Self-citationIntracytoplasmic Sperm Injection May Increase the Risk of Imprinting Defects
Cox, G. F., Bürger, J., Lip, V., Mau, U. A., Sperling, K., Wu, B.-L., & Horsthemke, B. (2002) · The American Journal of Human Genetics · doi:10.1086/341096 · Cited by 704
Bartolomei, M. S., & Tilghman, S. M. (1997) · Annual Review of Genetics · doi:10.1146/annurev.genet.31.1.493 · Cited by 631
Self-citationGenome Organization, Function, and Imprinting in Prader-Willi and Angelman Syndromes
Nicholls, R. D., & Knepper, J. L. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.153 · Cited by 625
Beckwith-Wiedemann syndrome and assisted reproduction technology (ART): Table 1
Maher, E. R., Brueton, L. A., Bowdin, S. C., Luharia, A., Cooper, W., Cole, T. R., Macdonald, F., Sampson, J. R., Barratt, C. L., Reik, W., et al. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.1.62 · Cited by 576
Khosla, S., Dean, W., Brown, D., Reik, W., & Feil, R. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.3.918 · Cited by 559
Ho, Y., Wigglesworth, K., Eppig, J. J., & Schultz, R. M. (1995) · Molecular Reproduction and Development · doi:10.1002/mrd.1080410214 · Cited by 550
Self-citationGicquel, C., Gaston, V., Mandelbaum, J., Siffroi, J.-P., Flahault, A., & Le Bouc, Y. (2003) · The American Journal of Human Genetics · doi:10.1086/374824 · Cited by 521
Xist RNA and the Mechanism of X Chromosome Inactivation
Plath, K., Mlynarczyk-Evans, S., Nusinow, D. A., & Panning, B. (2002) · Annual Review of Genetics · doi:10.1146/annurev.genet.36.042902.092433 · Cited by 450
Methylation Dynamics of Imprinted Genes in Mouse Germ Cells
Lucifero, D., Mertineit, C., Clarke, H. J., Bestor, T. H., & Trasler, J. M. (2002) · Genomics · doi:10.1006/geno.2002.6732 · Cited by 417
A Modified and Improved Method for Bisulphite Based Cytosine Methylation Analysis
Olek, A., Oswald, J., & Walter, J. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.24.5064 · Cited by 376
Dean, W., Bowden, L., Aitchison, A., Klose, J., Moore, T., Meneses, J. J., Reik, W., & Feil, R. (1998) · Development · doi:10.1242/dev.125.12.2273 · Cited by 374
Ørstavik, K. H., Eiklid, K., van der Hagen, C. B., Spetalen, S., Kierulf, K., Skjeldal, O., & Buiting, K. (2003) · The American Journal of Human Genetics · doi:10.1086/346030 · Cited by 368
Tremblay, K. D., Duran, K. L., & Bartolomei, M. S. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4322 · Cited by 351
Self-citationWeksberg, R. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.11.1317 · Cited by 328
CTCF maintains differential methylation at the Igf2/H19 locus
Schoenherr, C. J., Levorse, J. M., & Tilghman, S. M. (2003) · Nature Genetics · doi:10.1038/ng1057 · Cited by 320
Mann, M. R. W., Chung, Y. G., Nolen, L. D., Verona, R. I., Latham, K. E., & Bartolomei, M. S. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.103.017293 · Cited by 312
Self-citationRegulation of imprinted X-chromosome inactivation in mice by Tsix
Sado, T., Wang, Z., Sasaki, H., & Li, E. (2001) · Development · doi:10.1242/dev.128.8.1275 · Cited by 309
Beckwith-Wiedemann syndrome: imprinting in clusters revisited
Maher, E. R., & Reik, W. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9340 · Cited by 297
Disruption of Imprinted X Inactivation by Parent-of-Origin Effects at Tsix
Lee, J. T. (2000) · Cell · doi:10.1016/s0092-8674(00)00101-x · Cited by 276
Genomic Imprinting: Intricacies of Epigenetic Regulation in Clusters
Verona, R. I., Mann, M. R. W., & Bartolomei, M. S. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111401.092717 · Cited by 275
Self-citationMultiple Mechanisms Regulate Imprinting of the Mouse Distal Chromosome 7 Gene Cluster
Caspary, T., Cleary, M. A., Baker, C. C., Guan, X.-J., & Tilghman, S. M. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.6.3466 · Cited by 247
Stage- and cell-specific expression of Dnmt3a and Dnmt3b during embryogenesis
Watanabe, D., Suetake, I., Tada, T., & Tajima, S. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00242-3 · Cited by 234
Maher, E. R. (2003) · Human Reproduction · doi:10.1093/humrep/deg486 · Cited by 230
Davis, T. L., Trasler, J. M., Moss, S. B., Yang, G. J., & Bartolomei, M. S. (1999) · Genomics · doi:10.1006/geno.1999.5813 · Cited by 222
Self-citationGenomic imprinting is disrupted in interspecific Peromyscus hybrids
Vrana, P. B., Guan, X.-J., Ingram, R. S., & Tilghman., S. M. (1998) · Nature Genetics · doi:10.1038/3833 · Cited by 186
Adult phenotype in the mouse can be affected by epigenetic events in the early embryo
Reik, W., Römer, I., Barton, S. C., Surani, M. A., Howlett, S. K., & Klose, J. (1993) · Development · doi:10.1242/dev.119.3.933 · Cited by 182
Yamazaki, Y., Mann, M. R. W., Lee, S. S., Marh, J., McCarrey, J. R., Yanagimachi, R., & Bartolomei, M. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2035119100 · Cited by 170
Self-citationGenetic and epigenetic incompatibilities underlie hybrid dysgenesis in Peromyscus
Vrana, P. B., Fossella, J. A., Matteson, P., del Rio, T., O'Neill, M. J., & Tilghman, S. M. (2000) · Nature Genetics · doi:10.1038/75518 · Cited by 167
Temporal and spatial regulation of H19 imprinting in normal and uniparental mouse embryos
Sasaki, H., Ferguson‐Smith, A. C., Shum, A. S. W., Barton, S. C., & Surani, M. A. (1995) · Development · doi:10.1242/dev.121.12.4195 · Cited by 144
Huntriss, J., Hinkins, M., Oliver, B. G. G., Harris, S. E., Beazley, J., Rutherford, A. J., Gosden, R. G., Lanzendorf, S. E., & Picton, H. M. (2004) · Molecular Reproduction and Development · doi:10.1002/mrd.20030 · Cited by 129
Mechanisms of Genomic Imprinting
Pfeifer, K. E. (2000) · The American Journal of Human Genetics · doi:10.1086/303101 · Cited by 111
Tanaka, M., Puchyr, M., Gertsenstein, M., Harpal, K., Jaenisch, R., Rossant, J., & Nagy, A. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(99)00158-6 · Cited by 92
McDonald, L. E., Paterson, C. A., & Kay, G. F. (1998) · Genomics · doi:10.1006/geno.1998.5570 · Cited by 67
Autosomal Dominant Mutations Affecting X Inactivation Choice in the Mouse
Percec, I., Plenge, R. M., Nadeau, J. H., Bartolomei, M. S., & Willard, H. F. (2002) · Science · doi:10.1126/science.1070087 · Cited by 59
Self-citation
Cited by
DNA methylation and human disease
Robertson, K. D. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1655 · Cited by 2,864
X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease
Lee, J. T., & Bartolomei, M. S. (2013) · Cell · doi:10.1016/j.cell.2013.02.016 · Cited by 676
Self-citationJavierre, B. M., Fernandez, A. F., Richter, J., Al-Shahrour, F., Martin-Subero, J. I., Rodriguez-Ubreva, J., Berdasco, M., Fraga, M. F., O'Hanlon, T. P., Rider, L. G., et al. (2010) · Genome Research · doi:10.1101/gr.100289.109 · Cited by 668
Hirasawa, R., Chiba, H., Kaneda, M., Tajima, S., Li, E., Jaenisch, R., & Sasaki, H. (2008) · Genes & Development · doi:10.1101/gad.1667008 · Cited by 489
DNA methylation and gene expression differences in children conceived in vitro or in vivo
Katari, S., Turan, N., Bibikova, M., Erinle, O., Chalian, R., Foster, M., Gaughan, J. P., Coutifaris, C., & Sapienza, C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp319 · Cited by 470
Metadata
- Authors
- Mann, M. R. W., Lee, S. S., Doherty, A. S., Verona, R. I., Nolen, L. D., Schultz, R. M., & Bartolomei, M. S.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2004-08-01
- Volume
- 131
- Issue
- 15
- Pages
- 3727-3735
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2127905342
- Cited by
- 431
- References
- 44
- FWCI
- 13.81
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
