The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning
Open accessAbstract
Sonic hedgehog (Shh) ligand secreted by the notochord induces distinct ventral cell identities in the adjacent neural tube by a concentration-dependent mechanism. To study this process, we genetically engineered mice that produce bioactive, fluorescently labeled Shh from the endogenous locus. We show that Shh ligand concentrates in close association with the apically positioned basal body of neural target cells, forming a dynamic, punctate gradient in the ventral neural tube. Both ligand lipidation and target field response influence the gradient profile, but not the ability of Shh to concentrate around the basal body. Further, subcellular analysis suggests that Shh from the notochord might traffic into the neural target field by means of an apical-to-basal-oriented microtubule scaffold. This study, in which we directly observe, measure, localize and modify notochord-derived Shh ligand in the context of neural patterning, provides several new insights into mechanisms of Shh morphogen action.
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Cites
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696
Vertebrate Smoothened functions at the primary cilium
Corbit, K. C., Aanstad, P., Singla, V., Norman, A. R., Stainier, D. Y. R., & Reiter, J. F. (2005) · Nature · doi:10.1038/nature04117 · Cited by 1,481
Patched1 Regulates Hedgehog Signaling at the Primary Cilium
Rohatgi, R., Milenkovic, L., & Scott, M. P. (2007) · Science · doi:10.1126/science.1139740 · Cited by 1,426
Haycraft, C. J., Banizs, B., Aydin-Son, Y., Zhang, Q., Michaud, E. J., & Yoder, B. K. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010053 · Cited by 902
Cilia and Hedgehog responsiveness in the mouse
Huangfu, D., & Anderson, K. V. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505328102 · Cited by 820
Transcytosis: Crossing Cellular Barriers
TUMA, P. L., & HUBBARD, A. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00001.2003 · Cited by 681
Cited by
Dessaud, E., McMahon, A. P., & Briscoe, J. (2008) · Development · doi:10.1242/dev.009324 · Cited by 734
Self-citationMechanisms and functions of Hedgehog signalling across the metazoa
Ingham, P. W., Nakano, Y., & Seger, C. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2984 · Cited by 605
Morphogen rules: design principles of gradient-mediated embryo patterning
Briscoe, J., & Small, S. (2015) · Development · doi:10.1242/dev.129452 · Cited by 490
Ribes, V., & Briscoe, J. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002014 · Cited by 232
Dessaud, E., Ribes, V., Balaskas, N., Yang, L. L., Pierani, A., Kicheva, A., Novitch, B. G., Briscoe, J., & Sasai, N. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000382 · Cited by 203
Metadata
- Authors
- Chamberlain, C. E., Jeong, J., Guo, C., Allen, B. L., & McMahon, A. P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2008-03-15
- Volume
- 135
- Issue
- 6
- Pages
- 1097-1106
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1990633759
- Cited by
- 250
- References
- 8
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chamberlain, C. E., Jeong, J., Guo, C., Allen, B. L., & McMahon, A. P. (2008). Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning. Development. https://doi.org/10.1242/dev.013086
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
