The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Sp8 and Sp9 , two closely related buttonhead -like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos
Abstract
Initiation and maintenance of signaling centers is a key issue during embryonic development. The apical ectodermal ridge, a specialized epithelial structure and source of Fgf8, is a pivotal signaling center for limb outgrowth. We show that two closely related buttonhead-like zinc-finger transcription factors, Sp8 and Sp9, are expressed in the AER, and regulate Fgf8 expression and limb outgrowth. Embryological and genetic analyses have revealed that Sp8and Sp9 are ectodermal targets of Fgf10 signaling from the mesenchyme. We also found that Wnt/β-catenin signaling positively regulates Sp8, but not Sp9. Overexpression functional analyses in chick unveiled their role as positive regulators of Fgf8expression. Moreover, a dominant-negative approach in chick and knockdown analysis with morpholinos in zebrafish revealed their requirement for Fgf8 expression and limb outgrowth, and further indicate that they have a coordinated action on Fgf8 expression. Our study demonstrates that Sp8 and Sp9, via Fgf8, are involved in mediating the actions of Fgf10 and Wnt/β-catenin signaling during vertebrate limb outgrowth.
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Cites
Receptor Specificity of the Fibroblast Growth Factor Family
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Distinct WNT Pathways Regulating AER Formation and Dorsoventral Polarity in the Chick Limb Bud
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Cited by
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050
Distinct Wnt signaling pathways have opposing roles in appendage regeneration
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Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers
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Identification of a regeneration-organizing cell in the Xenopus tail
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Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2
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“In parallel, we examined the expression of genes that are induced by FGF signaling (Sp8, Erm, Pea3, Er81; Bell et al., 2003; Fukuchi-Shimogori and Grove, 2003; Kawakami et al., 2004; Storm et al., 2006).”
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Metadata
- Authors
- Kawakami, Y., Esteban, C. R., Matsui, T., Rodríguez-León, J., Kato, S., & Belmonte, J. C. I.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2004-10-01
- Volume
- 131
- Issue
- 19
- Pages
- 4763-4774
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1978717021
- Cited by
- 161
- References
- 4
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- closed
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