The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers
Abstract
Mouse embryos bearing hypomorphic and conditional null Fgf8mutations have small and abnormally patterned telencephalons. We provide evidence that the hypoplasia results from decreased Foxg1 expression,reduced cell proliferation and increased cell death. In addition, alterations in the expression of Bmp4, Wnt8b, Nkx2.1 and Shh are associated with abnormal development of dorsal and ventral structures. Furthermore, nonlinear effects of Fgf8 gene dose on the expression of a subset of genes, including Bmp4 and Msx1, correlate with a holoprosencephaly phenotype and with the nonlinear expression of transcription factors that regulate neocortical patterning. These data suggest that Fgf8 functions to coordinate multiple patterning centers, and that modifications in the relative strength of FGF signaling can have profound effects on the relative size and nature of telencephalic subdivisions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Crossley, P. H., & Martin, G. R. (1995) · Development · doi:10.1242/dev.121.2.439 · Cited by 1,174
Self-citationAn Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
Meyers, E. N., Lewandoski, M., & Martin, G. R. (1998) · Nature Genetics · doi:10.1038/ng0298-136 · Cited by 1,031
Self-citationSeoane, J., Le, H.-V., Shen, L., Anderson, S. A., & Massagué, J. (2004) · Cell · doi:10.1016/s0092-8674(04)00298-3 · Cited by 1,028
FGF and Shh Signals Control Dopaminergic and Serotonergic Cell Fate in the Anterior Neural Plate
Ye, W., Shimamura, K., Rubenstein, J. L. R., Hynes, M. A., & Rosenthal, A. (1998) · Cell · doi:10.1016/s0092-8674(00)81437-3 · Cited by 879
Self-citationOpposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
Kretzschmar, M., Doody, J., & Massagu, J. (1997) · Nature · doi:10.1038/39348 · Cited by 877
Sussel, L., Marin, O., Kimura, S., & Rubenstein, J. L. R. (1999) · Development · doi:10.1242/dev.126.15.3359 · Cited by 873
Self-citationTbr1 regulates differentiation of the preplate and layer 6
Hevner, R. F., Shi, L., Justice, N., Hsueh, Y.-P., Sheng, M., Smiga, S., Bulfone, A., Goffinet, A. M., Campagnoni, A. T., & Rubenstein, J. L. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00211-2 · Cited by 857
Self-citationBone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development
Furuta, Y., Piston, D. W., & Hogan, B. L. M. (1997) · Development · doi:10.1242/dev.124.11.2203 · Cited by 709
Neocortex Patterning by the Secreted Signaling Molecule FGF8
Fukuchi-Shimogori, T., & Grove, E. A. (2001) · Science · doi:10.1126/science.1064252 · Cited by 708
Inductive interactions direct early regionalization of the mouse forebrain
Shimamura, K., & Rubenstein, J. L. R. (1997) · Development · doi:10.1242/dev.124.14.2709 · Cited by 660
Self-citation
Cited by
Evolution of the neocortex: a perspective from developmental biology
Rakic, P. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2719 · Cited by 1,565
Kadoshima, T., Sakaguchi, H., Nakano, T., Soen, M., Ando, S., Eiraku, M., & Sasai, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315710110 · Cited by 999
The origin and specification of cortical interneurons
Wonders, C. P., & Anderson, S. A. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1954 · Cited by 980
Flames, N., Pla, R., Gelman, D. M., Rubenstein, J. L. R., Puelles, L., & Marín, O. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2750-07.2007 · Cited by 560
Self-citationNew insights into the development of the human cerebral cortex
Molnár, Z., Clowry, G. J., Šestan, N., Alzu'bi, A., Bakken, T., Hevner, R. F., Hüppi, P. S., Kostović, I., Rakic, P., Anton, E. S., et al. (2019) · Journal of Anatomy · doi:10.1111/joa.13055 · Cited by 401
The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes
Butt, S. J. B., Sousa, V. H., Fuccillo, M. V., Hjerling-Leffler, J., Miyoshi, G., Kimura, S., & Fishell, G. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.031 · Cited by 330
Decision by division: making cortical maps
Rakic, P., Ayoub, A. E., Breunig, J. J., & Dominguez, M. H. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.01.007 · Cited by 287
The molecular genetics of holoprosencephaly
Roessler, E., & Muenke, M. (2010) · American Journal of Medical Genetics Part C: Seminars in Medical Genetics · doi:10.1002/ajmg.c.30236 · Cited by 255
Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder
Rubenstein, J. L. (2010) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328336eb13 · Cited by 230
Self-citationXu, Q., Guo, L., Moore, H., Waclaw, R. R., Campbell, K., & Anderson, S. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.004 · Cited by 218
Flandin, P., Zhao, Y., Vogt, D., Jeong, J., Long, J., Potter, G., Westphal, H., & Rubenstein, J. L. R. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.020 · Cited by 155
Self-citationPatterning of frontal cortex subdivisions by Fgf17
Cholfin, J. A., & Rubenstein, J. L. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702225104 · Cited by 154
Self-citationBasal forebrain cholinergic signalling: development, connectivity and roles in cognition
Ananth, M. R., Rajebhosale, P., Kim, R., Talmage, D. A., & Role, L. W. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00677-x · Cited by 148
Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2
Cholfin, J. A., & Rubenstein, J. L. R. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21709 · Cited by 137
“…of transcription factors and other regulatory molecules in the cortical neuroepithelium, consistent with the protomap model of cortical development (for review see Garel and Rubenstein, 2004; Grove and FukuchiShimogori, 2003; O’Leary and Nakagawa, 2002; Rakic, 1988; Sur and Rubenstein, 2005).”
MethodSelf-citationSonic hedgehog functions through dynamic changes in temporal competence in the developing forebrain
Sousa, V. H., & Fishell, G. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.04.008 · Cited by 106
“Shh-mediated competence appears to regulate FGF signaling Contexts in which Shh or FGF signaling are perturbed result in a disruption in ventral telencephalic patterning [63,67 ,68].”
Patterning the Dorsal Telencephalon: A Role for Sonic Hedgehog?
Rash, B. G., & Grove, E. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3204-07.2007 · Cited by 103
Morozov, Y. M., Torii, M., & Rakic, P. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp028 · Cited by 94
The origins of the circumventricular organs
Kiecker, C. (2018) · Journal of Anatomy · doi:10.1111/joa.12771 · Cited by 92
Radial glia in the ventral telencephalon
Turrero García, M., & Harwell, C. C. (2017) · FEBS Letters · doi:10.1002/1873-3468.12829 · Cited by 62
Peyre, E., Silva, C. G., & Nguyen, L. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00129 · Cited by 51
Micali, N., Kim, S.-K., Diaz-Bustamante, M., Stein-O’Brien, G., Seo, S., Shin, J.-H., Rash, B. G., Ma, S., Wang, Y., Olivares, N. A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107599 · Cited by 31
Area Patterning of the Mammalian Cortex
O'Leary, D. D. M., Stocker, A. M., & Zembrzycki, A. (2013) · Patterning and Cell Type Specification in the Developing CNS and PNS · doi:10.1016/b978-0-12-397265-1.00021-6 · Cited by 14
Metadata
- Authors
- Storm, E. E., Garel, S., Borello, U., Hebert, J. M., Martinez, S., McConnell, S. K., Martin, G. R., & Rubenstein, J. L. R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2006-05-01
- Volume
- 133
- Issue
- 9
- Pages
- 1831-1844
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1970783808
- Cited by
- 366
- References
- 88
- FWCI
- 11.66
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
