The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation
Open accessAbstract
The planar cell polarity (PCP) pathway is conserved throughout evolution,but it mediates distinct developmental processes. In Drosophila,members of the PCP pathway localize in a polarized fashion to specify the cellular polarity within the plane of the epithelium, perpendicular to the apicobasal axis of the cell. In Xenopus and zebrafish, several homologs of the components of the fly PCP pathway control convergent extension. We have shown previously that mammalian PCP homologs regulate both cell polarity and polarized extension in the cochlea in the mouse. Here we show, using mice with null mutations in two mammalian Dishevelledhomologs, Dvl1 and Dvl2, that during neurulation a homologous mammalian PCP pathway regulates concomitant lengthening and narrowing of the neural plate, a morphogenetic process defined as convergent extension. Dvl2 genetically interacts with Loop-tail, a point mutation in the mammalian PCP gene Vangl2, during neurulation. By generating Dvl2 BAC (bacterial artificial chromosome) transgenes and introducing different domain deletions and a point mutation identical to the dsh1 allele in fly, we further demonstrated a high degree of conservation between Dvl function in mammalian convergent extension and the PCP pathway in fly. In the neuroepithelium of neurulating embryos, Dvl2 shows DEP domain-dependent membrane localization, a pre-requisite for its involvement in convergent extension. Intriguing, the Loop-tailmutation that disrupts both convergent extension in the neuroepithelium and PCP in the cochlea does not disrupt Dvl2 membrane distribution in the neuroepithelium, in contrast to its drastic effect on Dvl2 localization in the cochlea. These results are discussed in light of recent models on PCP and convergent extension.
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Cites
Zebrafish Prickle, a Modulator of Noncanonical Wnt/Fz Signaling, Regulates Gastrulation Movements
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Dishevelled controls cell polarity during Xenopus gastrulation
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Self-citationIdentification of Vangl2 and Scrb1 as planar polarity genes in mammals
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Self-citationZebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements
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Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1
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Self-citationThe planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos
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Self-citationHeads or tails: Wnts and anterior–posterior patterning
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Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish
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Self-citation
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Planar cell polarity in development and disease
Butler, M. T., & Wallingford, J. B. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.11 · Cited by 580
Self-citationPrinciples of planar polarity in animal development
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Planar Cell Polarity Signaling: From Fly Development to Human Disease
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Self-citationTissue/planar cell polarity in vertebrates: new insights and new questions
Wang, Y., & Nathans, J. (2007) · Development · doi:10.1242/dev.02772 · Cited by 442
Metadata
- Authors
- Wang, J., Hamblet, N. S., Mark, S., Dickinson, M. E., Brinkman, B. C., Segil, N., Fraser, S. E., Chen, P., Wallingford, J. B., & Wynshaw-Boris, A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2006-05-01
- Volume
- 133
- Issue
- 9
- Pages
- 1767-1778
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2057262868
- Cited by
- 356
- References
- 13
- FWCI
- 10.81
- Type
- journal article
- Language
- en
- Open access
- green
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