Polycomb/Trithorax response elements and epigenetic memory of cell identity

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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Polycomb complexes repress developmental regulators in murine embryonic stem cells

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Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells

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Role of histone H2A ubiquitination in Polycomb silencing

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

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Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex

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A genomic code for nucleosome positioning

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.

Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

Molofsky, A. V., Pardal, R., Iwashita, T., Park, I.-K., Clarke, M. F., & Morrison, S. J. (2003) · Nature · doi:10.1038/nature02060 · Cited by 1,310

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

Bracken, A. P., Dietrich, N., Pasini, D., Hansen, K. H., & Helin, K. (2006) · Genes & Development · doi:10.1101/gad.381706 · Cited by 1,257

The Histone Variant H3.3 Marks Active Chromatin by Replication-Independent Nucleosome Assembly

Ahmad, K., & Henikoff, S. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00542-7 · Cited by 1,112

Epigenetic Regulation of Cellular Memory by the Polycomb and Trithorax Group Proteins

Ringrose, L., & Paro, R. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.091907 · Cited by 1,077

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

Fischle, W., Wang, Y., Jacobs, S. A., Kim, Y., Allis, C. D., & Khorasanizadeh, S. (2003) · Genes & Development · doi:10.1101/gad.1110503 · Cited by 991

Highly Conserved Non-Coding Sequences Are Associated with Vertebrate Development

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The Polycomb-Group Gene Ezh2 Is Required for Early Mouse Development

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Stem Cells and Cancer

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Histone lysine methylation: a signature for chromatin function

Sims, R. J., Nishioka, K., & Reinberg, D. (2003) · Trends in Genetics · doi:10.1016/j.tig.2003.09.007 · Cited by 691

Binary switches and modification cassettes in histone biology and beyond

Fischle, W., Wang, Y., & David Allis, C. (2003) · Nature · doi:10.1038/nature02017 · Cited by 629

Genome-wide analysis of Polycomb targets in Drosophila melanogaster

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Hierarchical Recruitment of Polycomb Group Silencing Complexes

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Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

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Histone H3.3 is enriched in covalent modifications associated with active chromatin

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Genome-scale profiling of histone H3.3 replacement patterns

Mito, Y., Henikoff, J. G., & Henikoff, S. (2005) · Nature Genetics · doi:10.1038/ng1637 · Cited by 509

Displacement of sequence-specific transcription factors from mitotic chromatin

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The Drosophila Polycomb Group Gene pleiohomeotic Encodes a DNA Binding Protein with Homology to the Transcription Factor YY1

Brown, J. L., Mucci, D., Whiteley, M., Dirksen, M.-L., & Kassis, J. A. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80106-9 · Cited by 409

THE CRITICAL ROLE OF CHROMOSOME TRANSLOCATIONS IN HUMAN LEUKEMIAS

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Histone trimethylation and the maintenance of transcriptional ONand OFF states by trxG and PcG proteins

Papp, B., & Müller, J. (2006) · Genes & Development · doi:10.1101/gad.388706 · Cited by 397

A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities

Klymenko, T., Papp, B., Fischle, W., Köcher, T., Schelder, M., Fritsch, C., Wild, B., Wilm, M., & Müller, J. (2006) · Genes & Development · doi:10.1101/gad.377406 · Cited by 397

Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster

Tolhuis, B., Muijrers, I., de Wit, E., Teunissen, H., Talhout, W., van Steensel, B., & van Lohuizen, M. (2006) · Nature Genetics · doi:10.1038/ng1792 · Cited by 381

The Drosophila Fab-7 Chromosomal Element Conveys Epigenetic Inheritance during Mitosis and Meiosis

Cavalli, G., & Paro, R. (1998) · Cell · doi:10.1016/s0092-8674(00)81181-2 · Cited by 367

A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression.

Chan, C. S., Rastelli, L., & Pirrotta, V. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06545.x · Cited by 356

Genes and Signals

Ptashne, M., & Gann, A. A. F. (2001) · Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) · Cited by 356

Polycomb CBX7 has a unifying role in cellular lifespan.

Gil, J., Bernard, D., Martínez, D., & Beach, D. (2004) · Nature Cell Biology · doi:10.1038/ncb1077 · Cited by 341

Diverse mechanisms regulate stem cell self-renewal

Molofsky, A. V., Pardal, R., & Morrison, S. J. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.09.004 · Cited by 331

Elements of the Drosophila Bithorax Complex That Mediate Repression by Polycomb Group Products

Simon, J., Chiang, A., Bender, W., Shimell, M. J., & O'Connor, M. (1993) · Developmental Biology · doi:10.1006/dbio.1993.1174 · Cited by 325

Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function.

Rastelli, L., Chan, C. S., & Pirrotta, V. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05795.x · Cited by 316

In vivo binding pattern of a trans-regulator of homoeotic genes in Drosophila melanogaster

Zink, B., & Paro, R. (1989) · Nature · doi:10.1038/337468a0 · Cited by 305

Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products

Simon, J., Chiang, A., & Bender, W. (1992) · Development · doi:10.1242/dev.114.2.493 · Cited by 304

Chromatin dynamics at DNA replication, transcription and repair

Ehrenhofer‐Murray, A. E. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04162.x · Cited by 277

The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins

Klymenko, T., & Müller, J. (2004) · EMBO reports · doi:10.1038/sj.embor.7400111 · Cited by 264

Functional analysis of the chromo domain of HP1.

Platero, J. S., Hartnett, T., & Eissenberg, J. C. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00069.x · Cited by 262

Polycomb response elements and targeting of Polycomb group proteins in Drosophila

Müller, J., & Kassis, J. A. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.08.005 · Cited by 262

Genome-Wide Prediction of Polycomb/Trithorax Response Elements in Drosophila melanogaster

Ringrose, L., Rehmsmeier, M., Dura, J.-M., & Paro, R. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00337-x · Cited by 261

Polycomb group proteins and heritable silencing of Drosophila Hox genes

Beuchle, D., Struhl, G., & Müller, J. (2001) · Development · doi:10.1242/dev.128.6.993 · Cited by 248

Chromosomal Distribution of PcG Proteins during Drosophila Development

Nègre, N., Hennetin, J., Sun, L. V., Lavrov, S., Bellis, M., White, K. P., & Cavalli, G. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040170 · Cited by 247

Epigenetic Inheritance of Active Chromatin After Removal of the Main Transactivator

Cavalli, G., & Paro, R. (1999) · Science · doi:10.1126/science.286.5441.955 · Cited by 239

Co-localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression

Strutt, H. (1997) · The EMBO Journal · doi:10.1093/emboj/16.12.3621 · Cited by 232

Intergenic transcription through a Polycomb group response element counteracts silencing

Schmitt, S., Prestel, M., & Paro, R. (2005) · Genes & Development · doi:10.1101/gad.326205 · Cited by 230

An HMG-like protein that can switch a transcriptional activator to a repressor

Lehming, N., Thanos, D., Brickman, J. M., Ma, J., Maniatis, T., & Ptashne, M. (1994) · Nature · doi:10.1038/371175a0 · Cited by 225

Genomic Regulatory Networks and Animal Development

Stathopoulos, A., & Levine, M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.09.005 · Cited by 223

Division of labor in Polycomb group repression

Levine, S. S., King, I. F. G., & Kingston, R. E. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.07.007 · Cited by 219

Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs

Lee, N., Maurange, C., Ringrose, L., & Paro, R. (2005) · Nature · doi:10.1038/nature04120 · Cited by 211

Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing

Ferres-Marco, D., Gutierrez-Garcia, I., Vallejo, D. M., Bolivar, J., Gutierrez-Aviño, F. J., & Dominguez, M. (2006) · Nature · doi:10.1038/nature04376 · Cited by 206

A Polycomb and GAGA Dependent Silencer Adjoins the Fab-7 Boundary in the Drosophila Bithorax Complex

Hagstrom, K., Muller, M., & Schedl, P. (1997) · Genetics · doi:10.1093/genetics/146.4.1365 · Cited by 205

The ABC of the BX-C: the bithorax complex explained

Maeda, R. K., & Karch, F. (2006) · Development · doi:10.1242/dev.02323 · Cited by 200

The Distribution of Polycomb-Group Proteins During Cell Division and Development in Drosophila Embryos: Impact on Models for Silencing

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Condensed mitotic chromatin is accessible to transcription factors and chromatin structural proteins

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The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing

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Delving into the diversity of facultative heterochromatin: the epigenetics of the inactive X chromosome

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The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome-binding sites with Polycomb.

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Novel transcripts from the Ultrabithorax domain of the bithorax complex.

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Polycomb Group Gene rae28 Is Required for Sustaining Activity of Hematopoietic Stem Cells

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Distinct Contributions of Histone H3 Lysine 9 and 27 Methylation to Locus-Specific Stability of Polycomb Complexes

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Binding of Trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis

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Tissue-Specific TAFs Counteract Polycomb to Turn on Terminal Differentiation

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Interphase Cell Cycle Dynamics of a Late-Replicating, Heterochromatic Homogeneously Staining Region: Precise Choreography of Condensation/Decondensation and Nuclear Positioning

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Genome-Wide Analysis of Protein-DNA Interactions

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Marking of active genes on mitotic chromosomes

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MAPKAP Kinase 3pK Phosphorylates and Regulates Chromatin Association of the Polycomb Group Protein Bmi1

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Regulatory elements of the bithorax complex that control expression along the anterior-posterior axis

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Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1

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Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status

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Transcription through Intergenic Chromosomal Memory Elements of the Drosophila Bithorax Complex Correlates with an Epigenetic Switch

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Cellular memory and dynamic regulation of polycomb group proteins

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Polycomb group protein complexes exchange rapidly in living Drosophila

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Probing long-distance regulatory interactions in the Drosophila melanogaster bithorax complex using Dam identification

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Embryonic expression pattern of a family of Drosophila proteins that interact with a central nervous system regulatory element.Preprint

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The Drosophila ash1 Gene Product, Which Is Localized at Specific Sites on Polytene Chromosomes, Contains a SET Domain and a PHD Finger

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The Drosophila trithorax protein binds to specific chromosomal sites and is co‐localized with Polycomb at many sites.

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Discrete Polycomb-binding sites in each parasegmental domain of the bithorax complex

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Mapping of genetic and epigenetic regulatory networks using microarrays

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Mitotic chromosome condensation in the rDNA requires TRF4 and DNA topoisomerase I in Saccharomyces cerevisiae.Preprint

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A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc developmentPreprint

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Transcription through theiab-7 cis-regulatory domain of the bithorax complex interferes with maintenance ofPolycomb-mediated silencing

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The Role of mel-18, a Mammalian Polycomb Group Gene, during IL-7–Dependent Proliferation of Lymphocyte Precursors

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A silencer is required for maintenance of transcriptional repression throughout Drosophila development

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A role of polycomb group genes in the regulation of gap gene expression in Drosophila.

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Trithorax- and Polycomb-Group Response Elements within an Ultrabithorax Transcription Maintenance Unit Consist of Closely Situated but Separable Sequences

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Searching Chromatin for Stem Cell Identity

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pipsqueak Encodes a Factor Essential for Sequence-Specific Targeting of a Polycomb Group Protein Complex

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Site-Specific Recognition of a 70-Base-Pair Element Containing d(GA)n Repeats Mediatesbithoraxoid Polycomb Group Response Element-Dependent Silencing

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Architecture of a Polycomb Nucleoprotein Complex

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Spatially ordered transcription of regulatory DNA in the bithorax complex of Drosophila

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Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi-1

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Synergistic recognition of an epigenetic DNA element by Pleiohomeotic and a Polycomb core complexPreprint

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Chromatin inheritance upon Zeste‐mediated Brahma recruitment at a minimal cellular memory module

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An Sp1/KLF binding site is important for the activity of a Polycomb group response element from the Drosophila engrailed gene

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Interactions between an HMG-1 protein and members of the Rel family

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Transcription activates repressed domains in theDrosophilabithorax complex

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Efficient and Specific Targeting of Polycomb Group Proteins Requires Cooperative Interaction between Grainyhead and Pleiohomeotic

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Polycomb Group Proteins in Cell Cycle Progression and Cancer

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Hunchback‐independent silencing of late Ubx enhancers by a Polycomb Group Response Element.

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Characterization of two RNAs transcribed from the cis-regulatory region of the abd-A domain within the Drosophila bithorax complex.

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A Mosaic Genetic Screen Reveals Distinct Roles for trithorax and Polycomb Group Genes in Drosophila Eye Development

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Polycomb group-dependent Cyclin A repression in DrosophilaPreprint

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