The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos
Open accessAbstract
Hematopoietic cell clusters in the aorta of vertebrate embryos play a pivotal role in the formation of the adult blood system. Despite their importance, hematopoietic clusters have not been systematically quantitated or mapped because of technical limitations posed by the opaqueness of whole mouse embryos. Here, we combine an approach to make whole mouse embryos transparent, with multicolor marking, to allow observation of hematopoietic clusters using high-resolution 3-dimensional confocal microscopy. Our method provides the first complete map and temporal quantitation of all hematopoietic clusters in the mouse embryonic vasculature. We show that clusters peak in number at embryonic day 10.5, localize to specific vascular subregions and are heterogeneous, indicating a basal endothelial to non-basal (outer cluster) hematopoietic cell transition. Clusters enriched with the c-Kit+CD31+SSEA1– cell population contain functional hematopoietic progenitors and stem cells. Thus, three-dimensional cartography of transparent mouse embryos provides novel insight into the vascular subregions instrumental in hematopoietic progenitor/stem cell development, and represents an important technological advancement for comprehensive in situ hematopoietic cluster analysis.
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Cites
Wang, Q., Stacy, T., Binder, M., Marin-Padilla, M., Sharpe, A. H., & Speck, N. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3444 · Cited by 1,178
Of lineage and legacy: the development of mammalian hematopoietic stem cells
Dzierzak, E., & Speck, N. A. (2008) · Nature Immunology · doi:10.1038/ni1560 · Cited by 707
Self-citationCbfa2 is required for the formation of intra-aortic hematopoietic clusters
North, T., Gu, T.-L., Stacy, T., Wang, Q., Howard, L., Binder, M., Marín-Padilla, M., & Speck, N. A. (1999) · Development · doi:10.1242/dev.126.11.2563 · Cited by 662
The purification and characterization of fetal liver hematopoietic stem cells
Morrison, S. J., Hemmati, H. D., Wandycz, A. M., & Weissman, I. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10302 · Cited by 611
Requirement of Runx1/AML1/PEBP2αB for the generation of haematopoietic cells from endothelial cells
Yokomizo, T., Ogawa, M., Osato, M., Kanno, T., Yoshida, H., Fujimoto, T., Fraser, S., Nishikawa, S., Okada, H., Satake, M., et al. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00393.x · Cited by 176
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Cited by
Embryonic origin of the adult hematopoietic system: advances and questions
Medvinsky, A., Rybtsov, S., & Taoudi, S. (2011) · Development · doi:10.1242/dev.040998 · Cited by 403
Ditadi, A., Sturgeon, C. M., Tober, J., Awong, G., Kennedy, M., Yzaguirre, A. D., Azzola, L., Ng, E. S., Stanley, E. G., French, D. L., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3161 · Cited by 320
Ivanovs, A., Rybtsov, S., Welch, L., Anderson, R. A., Turner, M. L., & Medvinsky, A. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20111688 · Cited by 286
Gata2 is required for HSC generation and survival
de Pater, E., Kaimakis, P., Vink, C. S., Yokomizo, T., Yamada-Inagawa, T., van der Linden, R., Kartalaei, P. S., Camper, S. A., Speck, N., & Dzierzak, E. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130751 · Cited by 257
Self-citationLifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny
Ganuza, M., Hall, T., Finkelstein, D., Chabot, A., Kang, G., & McKinney-Freeman, S. (2017) · Nature Cell Biology · doi:10.1038/ncb3607 · Cited by 94
Metadata
- Authors
- Yokomizo, T., & Dzierzak, E.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2010-11-01
- Volume
- 137
- Issue
- 21
- Pages
- 3651-3661
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2140809916
- Cited by
- 270
- References
- 5
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- green
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