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Cited by 231

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Notch controls retinal blood vessel maturation and quiescence

Open access
Ehling, Manuel, Adams, Susanne, Benedito, Rui, Adams, Ralf H.·2013·Development
DOI 10.1242/dev.093351
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Abstract

Blood vessels form a hierarchically organized network of arteries, capillaries and veins, which develops through a series of growth, pruning and maturation processes. In contrast to the rapidly increasing insight into the processes controlling vascular growth and, in particular, endothelial sprouting and proliferation, the conversion of immature vessels into a fully functional, quiescent vasculature remains little understood. Here we used inducible, cell type-specific genetic approaches to show that endothelial Notch signaling is crucial for the remodeling of veins and the perivenous capillary plexus, which occurs after the completion of the initial angiogenic growth phase in the retina of adolescent mice. Mutant vessels showed ectopic proliferation and sprouting, defective recruitment of supporting mural cells, and failed to downregulate the expression of VEGF receptors. Surprisingly, by contrast Notch was dispensable in the endothelium of remodeling postnatal arteries. Taken together, our results identify key processes contributing to vessel remodeling, maturation and the acquisition of a quiescent phenotype in the final stage of developmental angiogenesis.

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Metadata

Authors
Ehling, M., Adams, S., Benedito, R., & Adams, R. H.
Venue
Development
Publisher
The Company of Biologists
Published
2013-07-15
Volume
140
Issue
14
Pages
3051-3061
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.093351
OpenAlex
W2082025181
Cited by
231
References
5
FWCI
5.11
Type
journal article
Language
en
Open access
bronze

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