TNF signaling and macrophages govern fin regeneration in zebrafish larvae
Open accessAbstract
Macrophages are essential for appendage regeneration after amputation in regenerative species. The molecular mechanisms through which macrophages orchestrate blastema formation and regeneration are still unclear. Here, we use the genetically tractable and transparent zebrafish larvae to study the functions of polarized macrophage subsets during caudal fin regeneration. After caudal fin amputation, we show an early and transient accumulation of pro-inflammatory macrophages concomitant with the accumulation of non-inflammatory macrophages which, in contrast to pro-inflammatory macrophages, remain associated to the fin until the end of the regeneration. Chemical and genetic depletion of macrophages suggested that early recruited macrophages that express TNF α are critical for blastema formation. Combining parabiosis and morpholino knockdown strategies, we show that TNF α/TNFR1 signaling pathway is required for the fin regeneration. Our study reveals that TNFR1 has a necessary and direct role in blastema cell activation suggesting that macrophage subset balance provides the accurate TNF α signal to prime regeneration in zebrafish.
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Death receptor signaling can also lead to NF-κB activation, generally resulting in cell survival associated with robust inflammatory response.
“Death receptor signaling can also lead to NF-κB activation, generally resulting in cell survival associated with a robust inflammatory response [272, 342].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [342]
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- Authors
- Nguyen-Chi, M., Laplace-Builhé, B., Travnickova, J., Luz-Crawford, P., Tejedor, G., Lutfalla, G., Kissa, K., Jorgensen, C., & Djouad, F.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Corresponding author
- Djouad, Farida
- Venue
- Cell Death & Disease
- Published
- 2017-08-10
- Volume
- 8
- Issue
- 8
- Pages
- e2979-e2979
- ISSN
- 2041-4889 (ISSN-L)
- PMC
- PMC5596562
- OpenAlex
- W2743154979
- Cited by
- 190
- References
- 46
- Citations by year
- 2026: 19 · 2025: 18 · 2024: 33 · 2023: 12 · 2022: 27 · 2021: 30 · 2020: 25 · 2019: 15 · 2018: 9 · 2017: 2
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-06-13)
- Open access
- gold
- doi.org
- Locations
- Cell Death and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-10-MIDI-009, ANR-10-MIDI-0009, ANR-10)
- Institut National de la Santé et de la Recherche Médicale
- Université de Montpellier
- FP7 People: Marie-Curie Actions (PITN-GA-2011-289209, FP7-PEOPLE-2011-ITN)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- TNF signaling, macrophages, fin regeneration, blastema formation, macrophage polarization, inflammatory macrophages, macrophage depletion, parabiosis, zebrafish larvae, appendage regeneration
- MeSH terms
- Animals, Extremities, Larva, Macrophages, Regeneration, Tumor Necrosis Factor-alpha, Zebrafish, Signal Transduction, Zebrafish Proteins, Animals, Genetically Modified, Receptors, Tumor Necrosis Factor, Type I
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