Cited by 46Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationNeuroscience and Neuropharmacology Research

The G protein-coupled receptor GPRC5B contributes to neurogenesis in the developing mouse neocortex

Kurabayashi, Nobuhiro, Nguyen, Minh Dang, Sanada, Kamon·2013·Development

Abstract

Neural progenitor cells in the developing brain give rise to neurons and glia. Multiple extrinsic signalling molecules and their cognate membrane receptors have been identified to control neural progenitor fate. However, a role for G protein-coupled receptors in cell fate decisions in the brain remains largely putative. Here we show that GPRC5B, which encodes an orphan G protein-coupled receptor, is present in the ventricular surface of cortical progenitors in the mouse developing neocortex and is required for their neuronal differentiation. GPRC5B-depleted progenitors fail to adopt a neuronal fate and ultimately become astrocytes. Furthermore, GPRC5B-mediated signalling is associated with the proper regulation of β-catenin signalling, a pathway crucial for progenitor fate decision. Our study uncovers G protein-coupled receptor signalling in the neuronal fate determination of cortical progenitors.

Integrity signals

Registry

Crossref · 10.1242/dev.099754

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kurabayashi, N., Nguyen, M. D., & Sanada, K.
Affiliations
  • Molecular Genetics Research Laboratory, Graduate School of Science, The University of Tokyo (JP)
  • University of Calgary (CA)
Corresponding author
Sanada, Kamon
Venue
Development
Published
2013-11-01
Volume
140
Issue
21
Pages
4335-4346
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
OpenAlex
W2049774426
Cited by
46
References
51
Citations by year
2026: 1 · 2025: 7 · 2024: 2 · 2023: 1 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 6
FWCI
1.24
Type
journal article
Language
en
Open access
closed
Locations
  • Development (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Washington
  • University of Tokyo
  • University of Illinois at Urbana-Champaign
  • Canadian Institutes of Health Research
  • Japan Society for the Promotion of Science (24650161, 24700314)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
GPRC5B, orphan G protein-coupled receptor, neurogenesis, neocortex development, cortical progenitor cells, neuronal differentiation, astrocyte differentiation, cell fate determination, β-catenin signaling, Wnt signaling, mouse brain development
MeSH terms
Animals, Cell Differentiation, Immunohistochemistry, Plasmids, Signal Transduction, In Situ Hybridization, DNA Primers, Electroporation, Gene Expression Regulation, Developmental, Neocortex, Receptors, G-Protein-Coupled, Mice, Neurogenesis, Neural Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review