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Cited by 242

The DOI matches its Crossref record.

Development of the pattern of cell renewal in the crypt-villus unit of chimaeric mouse small intestine

Schmidt, Günter H., Winton, Douglas J., Ponder, Bruce A. J.·1988·Development
DOI 10.1242/dev.103.4.785
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Abstract

We have previously shown that the epithelium of each adult intestinal crypt in chimaeric mice is derived from a single progenitor cell. Whether the crypts are monoclonal from the outset - that is, are formed by the proliferation of a single cell - or whether their formation is initiated by several cells was not known. Here we report that many crypts contain cells of both chimaeric genotypes in the neonatal period indicating a polyclonal origin at this stage of morphogenesis. The cellular organization of the early neonatal crypt is therefore different from that of the adult crypt, which includes a zone of ‘anchored’ stem cells above the crypt base. Within 2 weeks, however, the crypt progenitor cell and its descendants displace all other cells from the crypt and the crypt attains monocle-nality. The distribution of enterocytes on chimaeric villi in the neonate shows a mottled pattern of mosaicism which is progressively replaced by coherent sheets of cells from the crypts, and within two weeks the orderly adult clonal pattern is established.

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Metadata

Authors
Schmidt, G. H., Winton, D. J., & Ponder, B. A. J.
Venue
Development
Publisher
The Company of Biologists
Published
1988-08-01
Volume
103
Issue
4
Pages
785-790
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.103.4.785
OpenAlex
W2130943303
Cited by
242
References
0
FWCI
3.58
Type
journal article
Language
en
Open access
closed

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