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Cited by 285

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo

Open access
Cox, Brandon C., Chai, Renjie, Lenoir, Anne, Liu, Zhiyong, Zhang, LingLi, Nguyen, Duc-Huy, Chalasani, Kavita, Steigelman, Katherine A., Fang, Jie, Cheng, Alan G., Zuo, Jian·2014·Development
DOI 10.1242/dev.103036
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Abstract

Loss of cochlear hair cells in mammals is currently believed to be permanent, resulting in hearing impairment that affects more than 10% of the population. Here, we developed two genetic strategies to ablate neonatal mouse cochlear hair cells in vivo. Both Pou4f3DTR/+ and Atoh1-CreER™; ROSA26DTA/+ alleles allowed selective and inducible hair cell ablation. After hair cell loss was induced at birth, we observed spontaneous regeneration of hair cells. Fate-mapping experiments demonstrated that neighboring supporting cells acquired a hair cell fate, which increased in a basal to apical gradient, averaging over 120 regenerated hair cells per cochlea. The normally mitotically quiescent supporting cells proliferated after hair cell ablation. Concurrent fate mapping and labeling with mitotic tracers showed that regenerated hair cells were derived by both mitotic regeneration and direct transdifferentiation. Over time, regenerated hair cells followed a similar pattern of maturation to normal hair cell development, including the expression of prestin, a terminal differentiation marker of outer hair cells, although many new hair cells eventually died. Hair cell regeneration did not occur when ablation was induced at one week of age. Our findings demonstrate that the neonatal mouse cochlea is capable of spontaneous hair cell regeneration after damage in vivo. Thus, future studies on the neonatal cochlea might shed light on the competence of supporting cells to regenerate hair cells and on the factors that promote the survival of newly regenerated hair cells.

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Authors
Cox, B. C., Chai, R., Lenoir, A., Liu, Z., Zhang, L., Nguyen, D.-H., Chalasani, K., Steigelman, K. A., Fang, J., Cheng, A. G., & Zuo, J.
Venue
Development
Publisher
The Company of Biologists
Published
2014-02-15
Volume
141
Issue
4
Pages
816-829
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.103036
OpenAlex
W2156396097
Cited by
285
References
61
FWCI
14.23
Type
journal article
Language
en
Open access
green

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