The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death
Abstract
The low-affinity receptor for leukemia inhibitory factor (LIFR)* interacts with gp130 to induce an intracellular signal cascade. The LIFR-gp130 heterodimer is implicated in the function of diverse systems. Normal placentation is disrupted in LIFR mutant animals, which leads to poor intrauterine nutrition but allows fetuses to continue to term. Fetal bone volume is reduced greater than three-fold and the number of osteoclasts is increased six-fold, resulting in severe osteopenia of perinatal bone. Astrocyte numbers are reduced in the spinal cord and brain stem. Late gestation fetal livers contain relatively high stores of glycogen, indicating a metabolic disorder. Hematologic and primordial germ cell compartments appear normal. Pleiotropic defects in the mutant animals preclude survival beyond the day of birth.
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Cites
Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man
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Cited by
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
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Timing Is Everything: Making Neurons versus Glia in the Developing Cortex
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Pleiotropy and specificity: insights from the interleukin 6 family of cytokines
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Leukemia inhibitory factor (LIF)
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Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway
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Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
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SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation
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Metadata
- Authors
- Ware, C. B., Horowitz, M. C., Renshaw, B. R., Hunt, J. S., Liggitt, D., Koblar, S. A., Gliniak, B. C., McKenna, H. J., Papayannopoulou, T., Thoma, B., Cheng, L., Donovan, P. J., Peschon, J. J., Bartlett, P. F., Willis, C. R., Wright, B. D., Carpenter, M. K., Davison, B. L., & Gearing, D. P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-05-01
- Volume
- 121
- Issue
- 5
- Pages
- 1283-1299
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2167234515
- Cited by
- 586
- References
- 1
- FWCI
- 15.47
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
