The DOI matches its Crossref record.
Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis
Abstract
The hedgehog family of signaling proteins is associated with a variety of spatial patterning activities in insects and vertebrates. Here we show that new members of this family isolated from Xenopus laevis are expressed embryonically in patterns suggestive of roles in patterning in the ectoderm, nervous system and somites. Banded hedgehog is expressed throughout the neural plate and subsequently in both the nervous system and in the dermatome of somites. Cephalic hedgehog is expressed in anterior ectoderm and endodermal structures, and sonic hedgehog is expressed in patterns which parallel those in other species. Injection of RNAs encoding Xenopus hedgehogs induces ectopic cement gland formation in embryos. Similar to reported activities of noggin and follistatin, Xenopus hedgehogs share a common ability to induce cement glands in animal cap explants. However, hedgehog activities in naive ectoderm appear capable of acting independently of noggin and fol-listatin since, although all three are induced by activin in animal cap explants, X-hh expression does not induce noggin or follistatin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly
Roessler, E., Belloni, E., Gaudenz, K., Jay, P., Berta, P., Scherer, S. W., Tsui, L.-C., & Muenke, M. (1996) · Nature Genetics · doi:10.1038/ng1196-357 · Cited by 1,152
FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER
Harland, R., & Gerhart, J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.611 · Cited by 839
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J., & Hui, C.-C. (1998) · Development · doi:10.1242/dev.125.14.2533 · Cited by 451
Park, T. J., Haigo, S. L., & Wallingford, J. B. (2006) · Nature Genetics · doi:10.1038/ng1753 · Cited by 389
Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog
Blagden, C. S., Currie, P. D., Ingham, P. W., & Hughes, S. M. (1997) · Genes & Development · doi:10.1101/gad.11.17.2163 · Cited by 357
Hall, T. M. T., Porter, J. A., Young, K. E., Koonin, E. V., Beachy, P. A., & Leahy, D. J. (1997) · Cell · doi:10.1016/s0092-8674(01)80011-8 · Cited by 275
Self-citationXu, Y., Xu, C., Kato, A., Tempel, W., Abreu, J. G., Bian, C., Hu, Y., Hu, D., Zhao, B., Cerovina, T., et al. (2012) · Cell · doi:10.1016/j.cell.2012.11.014 · Cited by 271
Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog
Altaba, A. R. I. (1998) · Development · doi:10.1242/dev.125.12.2203 · Cited by 199
Development of the annelid axochord: Insights into notochord evolution
Lauri, A., Brunet, T., Handberg-Thorsager, M., Fischer, A. H. L., Simakov, O., Steinmetz, P. R. H., Tomer, R., Keller, P. J., & Arendt, D. (2014) · Science · doi:10.1126/science.1253396 · Cited by 104
Koide, T., Hayata, T., & Cho, K. W. Y. (2006) · Development · doi:10.1242/dev.02393 · Cited by 69
Metadata
- Authors
- Ekker, S. C., Lynn McGrew, L., Lai, C.-J., Lee, J. J., von Kessler, D. P., Moon, R. T., & Beachy, P. A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-08-01
- Volume
- 121
- Issue
- 8
- Pages
- 2337-2347
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1895875855
- Cited by
- 203
- References
- 0
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
