The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
Abstract
Floor plate cells at the midline of the neural tube are specified by high-level activity of Sonic hedgehog (Shh) secreted by notochord, whereas motor neurons are thought to be specified by a lower level activity of Shh secreted in turn by floor plate cells. In Drosophila, the Gli zinc finger protein Cubitus interruptus functions as a transcription factor activating Hedgehog-responsive genes. We report that the expression of known Shh-responsive genes such as Ptc and Gli1 is downregulated in mutant mice lacking Gli2 function. Gli2 mutants fail to develop a floor plate yet still develop motor neurons, which occupy the ventral midline of the neural tube. Our results imply that Gli2 is required to mediate high level but not low level Shh activity and show that the development of motor neurons can occur in the absence of floor plate induction.
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Cites
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Cited by
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
Hedgehog: functions and mechanisms
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1 Developmental roles and clinical significance of Hedgehog signaling
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Metadata
- Authors
- Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J., & Hui, C.-C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-07-15
- Volume
- 125
- Issue
- 14
- Pages
- 2533-2543
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1950508909
- Cited by
- 451
- References
- 64
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. https://app.cochat.ai/papers/10.1242/dev.125.14.2533
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- Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J., & Hui, C.-C. (1998). Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development. https://doi.org/10.1242/dev.125.14.2533
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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