The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats
Abstract
We present a molecular and genetic analysis which elucidates the role of deltex in the Notch signaling pathway. Using the yeast ‘interaction trap’ assay, we define the protein regions responsible for heterotypic interactions between Deltex and the intracellular domain of Notch as well as uncover homotypic interaction among Deltex molecules. The function of the Deltex-Notch interaction domains is examined by in vivo expression studies. Taken together, data from overexpression of Deltex fragments and from studies of physical interactions between Deltex and Notch, suggest that Deltex positively regulates the Notch pathway through interactions with the Notch ankyrin repeats. Experiments involving cell cultures indicate that the Deltex-Notch interaction prevents the cytoplasmic retention of the Suppressor of Hairless protein, which otherwise is sequestered in the cytoplasm via association with the Notch ankyrin repeats and translocates to the nucleus when Notch binds to its ligand Delta. On the basis of these findings, we propose a model wherein Deltex regulates Notch activity by antagonizing the interaction between Notch and Suppressor of Hairless.
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Cites
[1] Getting started with yeast
Sherman, F. (1991) · Methods in Enzymology · doi:10.1016/0076-6879(91)94004-v · Cited by 4,067
Improved method for high efficiency transformation of intact yeast cells
Gietz, D., Jean, A. S., Woods, R. A., & Schiestl, R. H. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.6.1425 · Cited by 3,261
The Genome of Drosophila Melanogaster
Lindsley, D. L., & Zimm, G. G. (1992) · Cited by 3,098
Drosophila — A Practical Approach
(1987) · Biochemical Education · doi:10.1016/0307-4412(87)90074-4 · Cited by 1,802
A stable genomic source of P element transposase in Drosophila melanogaster.
Robertson, H. M., Preston, C. R., Phillis, R. W., Johnson-Schlitz, D. M., Benz, W. K., & Engels, W. R. (1988) · Genetics · doi:10.1093/genetics/118.3.461 · Cited by 1,333
Artavanis-Tsakonas, S., Matsuno, K., & Fortini, M. E. (1995) · Science · doi:10.1126/science.7716513 · Cited by 1,303
Self-citationIdentification of a Ten-Amino Acid Proline-Rich SH3 Binding Site
Ren, R., Mayer, B. J., Cicchetti, P., & Baltimore, D. (1993) · Science · doi:10.1126/science.8438166 · Cited by 1,191
[10] Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast
Guarente, L. (1983) · Methods in Enzymology · doi:10.1016/0076-6879(83)01013-7 · Cited by 1,071
Wharton, K. A., Johansen, K. M., Xu, T., & Artavanis-Tsakonas, S. (1985) · Cell · doi:10.1016/0092-8674(85)90229-6 · Cited by 1,060
Self-citationMxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites
Zervos, A. S., Gyuris, J., & Brent, R. (1993) · Cell · doi:10.1016/0092-8674(93)90662-a · Cited by 775
Rebay, I., Fleming, R. J., Fehon, R. G., Cherbas, L., Cherbas, P., & Artavanis-Tsakonas, S. (1991) · Cell · doi:10.1016/0092-8674(91)90064-6 · Cited by 772
Self-citationFehon, R. G., Kooh, P. J., Rebay, I., Regan, C. L., Xu, T., Muskavitch, M. A. T., & Artavanis-Tsakonas, S. (1990) · Cell · doi:10.1016/0092-8674(90)90534-l · Cited by 673
Self-citationThe suppressor of hairless protein participates in notch receptor signaling
Fortini, M. (1994) · Cell · doi:10.1016/0092-8674(94)90196-1 · Cited by 536
Intrinsic activity of the lin-12 and Notch intracellular domains in vivo
Struhl, G., Fitzgerald, K., & Greenwald, I. (1993) · Cell · doi:10.1016/0092-8674(93)90424-o · Cited by 462
Simon, M. (1993) · Cell · doi:10.1016/0092-8674(93)90169-q · Cited by 448
Greenwald, I., & Rubin, G. M. (1992) · Cell · doi:10.1016/0092-8674(92)90470-w · Cited by 441
Kidd, S., Kelley, M. R., & Young, M. W. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.9.3094 · Cited by 425
The RING Finger: A Novel Protein Sequence Motif Related to the Zinc Finger
FREEMONT, P. S. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb32280.x · Cited by 424
Lieber, T., Kidd, S., Alcamo, E., Corbin, V, & Young, M. W. (1993) · Genes & Development · doi:10.1101/gad.7.10.1949 · Cited by 421
Rebay, I., Fehon, R. G., & Artavanis-Tsakonas, S. (1993) · Cell · doi:10.1016/0092-8674(93)90423-n · Cited by 409
Self-citationBreeden, L., & Nasmyth, K. (1987) · Nature · doi:10.1038/329651a0 · Cited by 370
Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos
Coffman, C. R., Skoglund, P., Harris, W. A., & Kintner, C. R. (1993) · Cell · doi:10.1016/0092-8674(93)90247-n · Cited by 369
A dual function of the Notch gene in Drosophila sensillum development
Hartenstein, V., & Posakony, J. W. (1990) · Developmental Biology · doi:10.1016/0012-1606(90)90147-b · Cited by 336
Vässin, H., Bremer, K. A., Knust, E., & Campos-Ortega, J. A. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02666.x · Cited by 311
An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye
Fortini, M. E., Rebay, I., Caron, L. A., & Artavanis-Tsakonas, S. (1993) · Nature · doi:10.1038/365555a0 · Cited by 301
Self-citationSchweisguth, F., & Posakony, J. W. (1992) · Cell · doi:10.1016/0092-8674(92)90641-o · Cited by 258
Kopczynski, C. C., Alton, A. K., Fechtel, K., Kooh, P. J., & Muskavitch, M. A. (1988) · Genes & Development · doi:10.1101/gad.2.12b.1723 · Cited by 245
Geisler, R., Bergmann, A., Hiromi, Y., & Nüsslein-Volhard, C. (1992) · Cell · doi:10.1016/0092-8674(92)90595-4 · Cited by 239
Kidd, S. (1992) · Cell · doi:10.1016/0092-8674(92)90596-5 · Cited by 224
Fleming, R. J., Scottgale, T. N., Diederich, R. J., & Artavanis-Tsakonas, S. (1990) · Genes & Development · doi:10.1101/gad.4.12a.2188 · Cited by 215
Self-citationDiederich, R. J., Matsuno, K., Hing, H., & Artavanis-Tsakonas, S. (1994) · Development · doi:10.1242/dev.120.3.473 · Cited by 207
Self-citationFunctional interactions of neurogenic genes of Drosophila melanogaster.
de-la-Concha, A., Dietrich, U., Weigel, D., & Campos-Ortega, J. A. (1988) · Genetics · doi:10.1093/genetics/118.3.499 · Cited by 158
The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis.Preprint
Xu, T., Rebay, I., Fleming, R. J., Scottgale, T. N., & Artavanis‐Tsakonas, S. (1990) · Genes & Development · doi:10.1101/gad.4.3.464 · Cited by 156
Self-citationSchweisguth, F., & Posakony, J. W. (1994) · Development · doi:10.1242/dev.120.6.1433 · Cited by 144
Smoller, D. A., Friedel, C., Schmid, A. T., Bettler, D. R., Lam, L., & Yedvobnick, B. (1990) · Genes & Development · doi:10.1101/gad.4.10.1688 · Cited by 140
Bang, A. G., & Posakony, J. W. (1992) · Genes & Development · doi:10.1101/gad.6.9.1752 · Cited by 140
Notch: Neurogenesis is only part of the picture
Fortini, M., & Artavanis‐Tsakonas, S. (1993) · Cell · doi:10.1016/0092-8674(93)90611-s · Cited by 137
Self-citationSchrons, H., Knust, E., & Campos‐Ortega, J. A. (1992) · Genetics · doi:10.1093/genetics/132.2.481 · Cited by 134
A common denominator linking glycogen metabolism, nuclear oncogenes and development
Woodgett, J. R. (1991) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(91)90071-3 · Cited by 133
Delidakis, C., Preiss, A., Hartley, D. A., & Artavanis‐Tsakonas, S. (1991) · Genetics · doi:10.1093/genetics/129.3.803 · Cited by 132
Self-citationGenetic Interactions in Early Neurogenesis of Drosophila melanogaster
Vaessin, H., Vielmetter, J., & Campos‐Ortega, J. A. (1985) · Journal of Neurogenetics · doi:10.3109/01677068509102325 · Cited by 132
Xu, T., & Artavanis‐Tsakonas, S. (1990) · Genetics · doi:10.1093/genetics/126.3.665 · Cited by 123
Self-citationFurukawa, T., Maruyama, S., Kawaichi, M., & Honjo, T. (1992) · Cell · doi:10.1016/0092-8674(92)90640-x · Cited by 115
Gertler, F. B., Hill, K. K., Clark, M. J., & Hoffmann, F. M. (1993) · Genes & Development · doi:10.1101/gad.7.3.441 · Cited by 111
ALLELIC NEGATIVE COMPLEMENTATION AT THE ABRUPTEX LOCUS OF DROSOPHILA MELANOGASTER
Portin, P. (1975) · Genetics · doi:10.1093/genetics/81.1.121 · Cited by 91
Hairless, a Drosophila gene involved in neural development, encodes a novel, serine rich protein
Maier, D., Stumm, G., Kuhn, K., & Preiss, A. (1992) · Mechanisms of Development · doi:10.1016/0925-4773(92)90006-6 · Cited by 85
Furukawa, T., Kawaichi, M., Matsunami, N., Ryo, H., Nishida, Y., & Honjo, T. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54501-4 · Cited by 66
Cited by
Notch signalling: a simple pathway becomes complex
Bray, S. J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2009 · Cited by 2,620
Notch signaling: simplicity in design, versatility in function
Andersson, E. R., Sandberg, R., & Lendahl, U. (2011) · Development · doi:10.1242/dev.063610 · Cited by 950
The ankyrin repeat as molecular architecture for protein recognition
Mosavi, L. K., Cammett, T. J., Desrosiers, D. C., & Peng, Z. (2004) · Protein Science · doi:10.1110/ps.03554604 · Cited by 907
Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane
Blaumueller, C. M., Qi, H., Zagouras, P., & Artavanis-Tsakonas, S. (1997) · Cell · doi:10.1016/s0092-8674(00)80336-0 · Cited by 614
Self-citationWu, L., Aster, J. C., Blacklow, S. C., Lake, R., Artavanis-Tsakonas, S., & Griffin, J. D. (2000) · Nature Genetics · doi:10.1038/82644 · Cited by 579
Self-citation
Metadata
- Authors
- Matsuno, K., Diederich, R. J., Go, M. J., Blaumueller, C. M., & Artavanis-Tsakonas, S.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1995-08-01
- Volume
- 121
- Issue
- 8
- Pages
- 2633-2644
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2160362993
- Cited by
- 320
- References
- 47
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
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