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Cited by 320

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Mos is required for MAP kinase activation and is involved in microtubule organization during meiotic maturation in the mouse

Verlhac, Marie-Hélène, Kubiak, Jacek Z., Weber, Michèle, Géraud, Gérard, Colledge, William H., Evans, Martin J., Maro, Bernard·1996·Development
DOI 10.1242/dev.122.3.815
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Abstract

Mos is normally expressed during oocyte meiotic maturation in vertebrates. However, apart from its cytostatic factor (CSF) activity, its precise role during mouse meiosis is still unknown. First, we analyzed its role as a MAP kinase kinase kinase. Mos is synthesized concomitantly with the activation of MAP kinase in mouse oocytes. Moreover, MAP kinase is not activated during meiosis in oocytes from mos–/– mice. This result implies that Mos is necessary for MAP kinase activation in mouse oocytes. Raf-1, another MAP kinase kinase kinase, is already present in immature oocytes, but does not seem to be active when MAP kinase is activated. Moreover, the absence of MAP kinase activation in mos–/– oocytes demonstrates that Raf-1 cannot compensate for the lack of Mos. These results suggest that Raf1 is not involved in MAP kinase activation. Second, we analyzed the organization of the microtubules and chromosomes in oocytes from mos–/– mice. We observed that during the transition between two meiotic M-phases, the microtubules and chromosomes evolve towards an interphase-like state in mos–/– oocytes, while in the control mos+/− oocytes they remain in an M-phase configuration, as in the wild type. Moreover, after spontaneous activation, the majority of mos–/– oocytes are arrested for at least 10 hours in a third meiotic M-phase where they exhibit monopolar half-spindles. These observations present the first evidence, in intact oocytes, of a role for the Mos/…/MAP kinase cascade in the control of microtubule and chromatin organization during meiosis.

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Metadata

Authors
Verlhac, M.-H., Kubiak, J. Z., Weber, M., Géraud, G., Colledge, W. H., Evans, M. J., & Maro, B.
Venue
Development
Publisher
The Company of Biologists
Published
1996-03-01
Volume
122
Issue
3
Pages
815-822
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.122.3.815
OpenAlex
W2120863005
Cited by
320
References
37
FWCI
27.88
Type
journal article
Language
en
Open access
closed

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