The DOI matches its Crossref record; 56 of the 59 references it cites were found in a registry or an index.
Notochord to endoderm signaling is required for pancreas development
Abstract
The role of the notochord in inducing and patterning adjacent neural and mesodermal tissues is well established. We provide evidence that the notochord is also required for one of the earliest known steps in the development of the pancreas, an endodermally derived organ. At a developmental stage in chick embryos when the notochord touches the endoderm, removal of notochord eliminates subsequent expression of several markers of dorsal pancreas bud development, including insulin, glucagon and carboxypeptidase A. Pancreatic gene expression can be initiated and maintained in prepancreatic chick endoderm grown in vitro with notochord. Non-pancreatic endoderm, however, does not express pancreatic genes when recombined with the same notochord. The results suggest that the notochord provides a permissive signal to endoderm to specify pan-creatic fate in a stepwise manner.
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“FGF2 and Activin, secreted by the notochord, lead to the expression of pancreatic markers by repressing expression of Shh in pancreatic endoderm [15-19].”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [18]
Citations
Cites
A series of normal stages in the development of the chick embryo
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Insulin-promoter-factor 1 is required for pancreas development in mice
Jonsson, J., Carlsson, L., Edlund, T., & Edlund, H. (1994) · Nature · doi:10.1038/371606a0 · Cited by 1,879
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
Offield, M. F., Jetton, T. L., Labosky, P. A., Ray, M., Stein, R. W., Magnuson, M. A., Hogan, B. L. M., & Wright, C. V. E. (1996) · Development · doi:10.1242/dev.122.3.983 · Cited by 1,514
Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
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Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
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Slack, J. M. W. (1995) · Development · doi:10.1242/dev.121.6.1569 · Cited by 947
IPF1, a homeodomain‐containing transactivator of the insulin gene.
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3 of the 59 references couldn’t be matched to a known paper.
Research works printed but not linked: 6
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Cited by
Sorted by citations
Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets
Lumelsky, N. L., Blondel, O., Laeng, P., Velasco, I., Ravin, R., & McKay, R. D. G. (2001) · Science · doi:10.1126/science.1058866 · Cited by 1,453
Induction of Pancreatic Differentiation by Signals from Blood Vessels
Lammert, E., Cleaver, O. B., & Melton, D. A. (2001) · Science · doi:10.1126/science.1064344 · Cited by 1,064
Self-citationNotochord repression of endodermal Sonic hedgehog permits pancreas development
Hebrok, M., Kim, S. K., & Melton, D. A. (1998) · Genes & Development · doi:10.1101/gad.12.11.1705 · Cited by 628
Self-citationPancreas organogenesis: From bud to plexus to gland
Pan, F. C., & Wright, C. V. E. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22584 · Cited by 647
α-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains
Gromada, J., Franklin, I., & Wollheim, C. B. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0007 · Cited by 596
Metadata
- Authors
- Kim, S. K., Hebrok, M., & Melton, D. A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-11-01
- Volume
- 124
- Issue
- 21
- Pages
- 4243-4252
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1844743435
- Cited by
- 405
- References
- 59
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 8 · 2022: 1 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 12 · 2012: 14
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Oncology › Renal and related cancers
- Keywords
- notochord, endoderm, pancreatic development, dorsal pancreas, insulin, glucagon, carboxypeptidase A, chick embryo, in vitro recombination
- MeSH terms
- Animals, Cells, Cultured, Chick Embryo, Embryonic Induction, Endoderm, Nerve Tissue Proteins, Notochord, Pancreas, Transcription Factors, Signal Transduction, Biomarkers, Trans-Activators, Homeodomain Proteins, Gene Expression Regulation, Developmental, LIM-Homeodomain Proteins
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