Cited by 406Developmental Biology and Gene RegulationPancreatic function and diabetesRenal and related cancers

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Notochord to endoderm signaling is required for pancreas development

Kim, Seung K., Hebrok, Matthias, Melton, Douglas A.·1997·Development

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Abstract

The role of the notochord in inducing and patterning adjacent neural and mesodermal tissues is well established. We provide evidence that the notochord is also required for one of the earliest known steps in the development of the pancreas, an endodermally derived organ. At a developmental stage in chick embryos when the notochord touches the endoderm, removal of notochord eliminates subsequent expression of several markers of dorsal pancreas bud development, including insulin, glucagon and carboxypeptidase A. Pancreatic gene expression can be initiated and maintained in prepancreatic chick endoderm grown in vitro with notochord. Non-pancreatic endoderm, however, does not express pancreatic genes when recombined with the same notochord. The results suggest that the notochord provides a permissive signal to endoderm to specify pan-creatic fate in a stepwise manner.

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Authors: Kim, S. K., Hebrok, M., & Melton, D. A.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Kim, Seung K.
Hebrok, Matthias
Melton, Douglas A.
Venue: Development
Publisher: The Company of Biologists
Published: 1997-11-01
Volume: 124
Issue: 21
Pages: 4243-4252
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.124.21.4243
OpenAlex: W1844743435
Cited by: 405
References: 59
Citations by year: 2026: 1 · 2025: 5 · 2024: 3 · 2023: 8 · 2022: 1 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 12 · 2012: 14
FWCI: 6.52
Type: journal article
Language: en
Open access: closed
Locations: Development (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Oncology › Renal and related cancers
Keywords: notochord, endoderm, pancreatic development, dorsal pancreas, insulin, glucagon, carboxypeptidase A, chick embryo, in vitro recombination
MeSH terms: Animals, Cells, Cultured, Chick Embryo, Embryonic Induction, Endoderm, Nerve Tissue Proteins, Notochord, Pancreas, Transcription Factors, Signal Transduction, Biomarkers, Trans-Activators, Homeodomain Proteins, Gene Expression Regulation, Developmental, LIM-Homeodomain Proteins

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Notochord to endoderm signaling is required for pancreas development

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