The DOI matches its Crossref record; 56 of the 59 references it cites were found in a registry or an index.
Notochord to endoderm signaling is required for pancreas development
Abstract
The role of the notochord in inducing and patterning adjacent neural and mesodermal tissues is well established. We provide evidence that the notochord is also required for one of the earliest known steps in the development of the pancreas, an endodermally derived organ. At a developmental stage in chick embryos when the notochord touches the endoderm, removal of notochord eliminates subsequent expression of several markers of dorsal pancreas bud development, including insulin, glucagon and carboxypeptidase A. Pancreatic gene expression can be initiated and maintained in prepancreatic chick endoderm grown in vitro with notochord. Non-pancreatic endoderm, however, does not express pancreatic genes when recombined with the same notochord. The results suggest that the notochord provides a permissive signal to endoderm to specify pan-creatic fate in a stepwise manner.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“FGF2 and Activin, secreted by the notochord, lead to the expression of pancreatic markers by repressing expression of Shh in pancreatic endoderm [15-19].”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [18]
Citations
Cites
A series of normal stages in the development of the chick embryo
Hamburger, V., & Hamilton, H. L. (1951) · Journal of Morphology · doi:10.1002/jmor.1050880104 · Cited by 12,254
Sonic hedgehog mediates the polarizing activity of the ZPA
Riddle, R. D., Johnson, R. L., Laufer, E., & Tabin, C. J. (1993) · Cell · doi:10.1016/0092-8674(93)90626-2 · Cited by 2,285
Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A., & McMahon, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90627-3 · Cited by 2,154
Insulin-promoter-factor 1 is required for pancreas development in mice
Jonsson, J., Carlsson, L., Edlund, T., & Edlund, H. (1994) · Nature · doi:10.1038/371606a0 · Cited by 1,879
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
Offield, M. F., Jetton, T. L., Labosky, P. A., Ray, M., Stein, R. W., Magnuson, M. A., Hogan, B. L. M., & Wright, C. V. E. (1996) · Development · doi:10.1242/dev.122.3.983 · Cited by 1,514
Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
Liem, K. F., Tremml, G., Roelink, H., & Jessell, T. M. (1995) · Cell · doi:10.1016/0092-8674(95)90276-7 · Cited by 1,071
Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
Tsuchida, T., Ensini, M., Brenner‐Morton, S., Baldassare, M., Edlund, H., Jessell, T. M., & Pfaff, S. L. (1994) · Cell · doi:10.1016/0092-8674(94)90027-2 · Cited by 997
Developmental biology of the pancreas
Slack, J. M. W. (1995) · Development · doi:10.1242/dev.121.6.1569 · Cited by 947
IPF1, a homeodomain‐containing transactivator of the insulin gene.
Ohlsson, H., Karlsson, K., & Edlund, H. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06109.x · Cited by 888
Roelink, H., Augsburger, A., Heemskerk, J., Korzh, V. P., Norlin, S., Altaba, A. R. I., Tanabe, Y., Placzek, M., Edlund, H., Jessell, T. M., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90514-2 · Cited by 854
Flagged first, then by citations
3 of the 59 references couldn’t be matched to a known paper.
Research works printed but not linked: 6
- Dieterlen-Lièvre, 1965, Étude morphologique et expérimentale de la différenciation du pancréas chez l’embryo de Poulet, Bull. Biol. France Belg, 99, 3
- Hogan, 1994, Manipulating the mouse embryo, 330
- Le Douarin, 1964, Étude expérimentale de l’organogenèse du tube digestif et du foie chez l’embryon de poulet, Bull. Biol. Fr. Belg, 98, 544
- Le Douarin, 1966, Détermination précoce et rôle inducteur de l’endoderme pharyngien chez l’embryon de Poulet, C. R. Acad. Sc. Paris, 263D, 1241
- Romanoff, 1960, The Avian Embryo, 526
- Sumiya, 1987, Étude immunohistologique de l’expression de glucagon dans l’endoderme pancréatique dorsal chez l’embryon précoce de Poulet, C.R. Soc. Biol, 181, 718
Cited by
Sorted by citations
Differentiation of Embryonic Stem Cells to Insulin-Secreting Structures Similar to Pancreatic Islets
Lumelsky, N. L., Blondel, O., Laeng, P., Velasco, I., Ravin, R., & McKay, R. D. G. (2001) · Science · doi:10.1126/science.1058866 · Cited by 1,453
Induction of Pancreatic Differentiation by Signals from Blood Vessels
Lammert, E., Cleaver, O. B., & Melton, D. A. (2001) · Science · doi:10.1126/science.1064344 · Cited by 1,064
Self-citationNotochord repression of endodermal Sonic hedgehog permits pancreas development
Hebrok, M., Kim, S. K., & Melton, D. A. (1998) · Genes & Development · doi:10.1101/gad.12.11.1705 · Cited by 628
Self-citationPancreas organogenesis: From bud to plexus to gland
Pan, F. C., & Wright, C. V. E. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22584 · Cited by 647
α-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains
Gromada, J., Franklin, I., & Wollheim, C. B. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0007 · Cited by 596
A bipotential precursor population for pancreas and liver within the embryonic endoderm
Deutsch, G., Jung, J., Zheng, M., Lóra, J., & Zaret, K. S. (2001) · Development · doi:10.1242/dev.128.6.871 · Cited by 611
Krapp, A., Knöfler, M., Ledermann, B., Bürki, K., Berney, C., Zoerkler, N., Hagenbüchle, O., & Wellauer, P. K. (1998) · Genes & Development · doi:10.1101/gad.12.23.3752 · Cited by 529
Generation of Insulin-Producing Islet-Like Clusters from Human Embryonic Stem Cells
Jiang, J., Au, M., Lu, K., Eshpeter, A., Korbutt, G. S., Fisk, G., & Majumdar, A. S. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0761 · Cited by 528
Pancreatic organogenesis — developmental mechanisms and implications for therapy
Edlund, H. (2002) · Nature Reviews Genetics · doi:10.1038/nrg841 · Cited by 522
Vertebrate Endoderm Development
Wells, J. M., & Melton, D. A. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.393 · Cited by 522
Self-citationBhushan, A., Itoh, N., Kato, S., Thiery, J. P., Czernichow, P., Bellusci, S., & Scharfmann, R. (2001) · Development · doi:10.1242/dev.128.24.5109 · Cited by 459
Developmental biology of the pancreas: A comprehensive review
Gittes, G. K. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.024 · Cited by 465
Structure and function of the notochord: an essential organ for chordate development
Stemple, D. L. (2005) · Development · doi:10.1242/dev.01812 · Cited by 443
Hruban, R., Adsay, N., Albores-saavedra, J., Anver, M., Biankin, A., Boivin, G. P., Furth, E., Furukawa, T., Klein, A., Klimstra, D., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2168 · Cited by 411
Regulation of pancreas development by hedgehog signaling
Hebrok, M., Kim, S. K., St-Jacques, B., McMahon, A. P., & Melton, D. A. (2000) · Development · doi:10.1242/dev.127.22.4905 · Cited by 412
Self-citationIntercellular signals regulating pancreas development and functionPreprint
Kim, S. K., & Hebrok, M. (2001) · Genes & Development · doi:10.1101/gad.859401 · Cited by 403
Self-citationMinireview: transcriptional regulation in pancreatic development.
Habener, J., Kemp, D. M., & Thomas, M. K. (2005) · Endocrinology · doi:10.1210/en.2004-1576 · Cited by 437
Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9
Li, H., Arber, S., Jessell, T. M., & Edlund, H. (1999) · Nature Genetics · doi:10.1038/12669 · Cited by 377
Gene regulatory factors in pancreatic development
Jensen, J. (2004) · Developmental Dynamics · doi:10.1002/dvdy.10460 · Cited by 397
An Illustrated Review of Early Pancreas Development in the Mouse
Jørgensen, M. C., Ahnfelt‐Rønne, J., Hald, J., Madsen, O. D., Serup, P., & Hecksher‐Sørensen, J. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0016 · Cited by 397
Early mouse endoderm is patterned by soluble factors from adjacent germ layers
Wells, J. M., & Melton, D. A. (2000) · Development · doi:10.1242/dev.127.8.1563 · Cited by 366
Self-citationPancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice
Harrison, K. A., Thaler, J. P., Pfaff, S. L., Gu, H., & Kehrl, J. H. (1999) · Nature Genetics · doi:10.1038/12674 · Cited by 358
Development of the Human Pancreas From Foregut to Endocrine Commitment
Jennings, R. E., Berry, A. A., Kirkwood-Wilson, R., Roberts, N. A., Hearn, T., Salisbury, R. J., Blaylock, J., Hanley, K. P., & Hanley, N. (2013) · Diabetes · doi:10.2337/db12-1479 · Cited by 285
Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract
van den Brink, G. R. (2007) · Physiological Reviews · doi:10.1152/physrev.00054.2006 · Cited by 317
Grapin‐Botton, A., Majithia, A. R., & Melton, D. A. (2001) · Genes & Development · doi:10.1101/gad.846001 · Cited by 296
Self-citationPancreas and beta-cell development: from the actual to the possible
Murtaugh, L. C. (2006) · Development · doi:10.1242/dev.02770 · Cited by 295
Endoderm development: from patterning to organogenesis
Grapin‐Botton, A., & Melton, D. A. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(99)01957-5 · Cited by 279
Self-citationThe Pathology and Genetics of Metastatic Pancreatic Cancer
Yachida, S., & Iacobuzio–Donahue, C. A. (2009) · Archives of Pathology & Laboratory Medicine · doi:10.5858/133.3.413 · Cited by 269
Lack of TCF2/vHNF1 in mice leads to pancreas agenesis.
Haumaître, C., Barbacci, E., Jenny, M., Ott, M., Gradwohl, G., & Cereghini, S. (2005) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0405776102 · Cited by 281
Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor
Kim, S. K., & Melton, D. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13036 · Cited by 265
Self-citationYoshitomi, H., & Zaret, K. S. (2004) · Development · doi:10.1242/dev.00960 · Cited by 264
Cirulli, V., & Yebra, M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2142 · Cited by 278
Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice.
Martín, M., Gallego-Llamas, J., Ribes, V., Kedinger, M., Niederreither, K., Chambon, P., Dollé, P., & Gradwohl, G. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.05.035 · Cited by 295
Role of endothelial cells in early pancreas and liver development
Lammert, E., Cleaver, O. B., & Melton, D. A. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00332-5 · Cited by 257
Self-citationHald, J., Hjorth, J., German, M. S., Madsen, O. D., Serup, P., & Jensen, J. N. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00326-9 · Cited by 251
Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate
Kumar, M. E., Jordan, N., Melton, D. A., & Grapin‐Botton, A. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00183-0 · Cited by 247
Self-citationMolecular Regulation of Lung Development
Cardoso, W. V. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.471 · Cited by 241
Signaling and transcriptional control of pancreatic organogenesis
Kim, S. K. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00338-6 · Cited by 239
Self-citationDynamic Signaling Network for the Specification of Embryonic Pancreas and Liver Progenitors
Wandzioch, E., & Zaret, K. S. (2009) · Science · doi:10.1126/science.1174497 · Cited by 244
Genes, Signals, and Lineages in Pancreas Development
Murtaugh, L. C., & Melton, D. A. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111301.144752 · Cited by 235
Self-citationDirect lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis.
Gu, G.-Q., Brown, J. R., & Melton, D. (2003) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00330-1 · Cited by 236
Self-citationFrom endoderm formation to liver and pancreas development in zebrafish
Ober, E. A., Field, H. A., & Stainier, D. Y. R. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00327-1 · Cited by 223
Biemar, F., Argenton, F., Schmidtke, R., Epperlein, S., Peers, B., & Driever, W. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0103 · Cited by 224
How to make a functional β-cell
Pagliuca, F. W., & Melton, D. A. (2013) · Development · doi:10.1242/dev.093187 · Cited by 226
Self-citationActivin receptor patterning of foregut organogenesis
Kim, S. K., Hebrok, M., Li, E., Oh, S. P., Schrewe, H., Harmon, E. B., Lee, J. S., & Melton, D. A. (2000) · Genes & Development · doi:10.1101/gad.14.15.1866 · Cited by 212
Self-citationKim, S. K., Selleri, L., Lee, J. S., Zhang, A. Y., Gu, X., Jacobs, Y., & Cleary, M. L. (2002) · Nature Genetics · doi:10.1038/ng860 · Cited by 203
Self-citationFoxa2 is required for the differentiation of pancreatic α-cells
Lee, C. S., Sund, N. J., Behr, R., Herrera, P. L., & Kaestner, K. H. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.10.012 · Cited by 199
Brachyury downstream notochord differentiation in the ascidian embryoPreprint
Takahashi, H., Hotta, K., Erives, A. J., Gregorio, A. D., Zeller, R. W., Levine, M., & Satoh, N. (1999) · Genes & Development · doi:10.1101/gad.13.12.1519 · Cited by 197
Transcriptional dynamics of endodermal organ formation
Sherwood, R. I., Chen, T. A., & Melton, D. A. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21810 · Cited by 191
Self-citationSordet‐Dessimoz, J., Opoka, R. J., Kordich, J. J., Grapin‐Botton, A., & Wells, J. M. (2005) · Mechanisms of Development · doi:10.1016/j.mod.2005.10.001 · Cited by 189
Tissue-specific deletion of Foxa2 in pancreatic β cells results in hyperinsulinemic hypoglycemiaPreprint
Sund, N. J., Vatamaniuk, M. Z., Casey, M. A., Ang, S., Magnuson, M. A., Stoffers, D. A., Matschinsky, F. M., & Kaestner, K. H. (2001) · Genes & Development · doi:10.1101/gad.901601 · Cited by 186
Haumaître, C., Lenoir, O., & Scharfmann, R. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00413-08 · Cited by 190
Foxa2 Controls Pdx1 Gene Expression in Pancreatic β-Cells In Vivo
Lee, C. S., Sund, N. J., Vatamaniuk, M. Z., Matschinsky, F. M., Stoffers, D. A., & Kaestner, K. H. (2002) · Diabetes · doi:10.2337/diabetes.51.8.2546 · Cited by 184
Jacquemin, P., Lemaigre, F., & Rousseau, G. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00115-5 · Cited by 187
Developmental biology of the pancreas.
Edlund, H. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s5 · Cited by 179
Burke, Z., & Oliver, G. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00240-x · Cited by 177
Insulin expressing cells from differentiated embryonic stem cells are not beta cells
Sipione, S., Eshpeter, A., Lyon, J. G., Korbutt, G. S., & Bleackley, R. C. (2004) · Diabetologia · doi:10.1007/s00125-004-1349-z · Cited by 174
Notochord vacuoles are lysosome-related organelles that function in axis and spine morphogenesis
Ellis, K., Bagwell, J., & Bagnat, M. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201212095 · Cited by 175
Miralles, F., Battelino, T., Czernichow, P., & Scharfmann, R. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.3.827 · Cited by 174
Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats
Li, W., Rukstalis, J. M., Nishimura, W., Tchipashvili, V., Habener, J. F., Sharma, A., & Bonner‐Weir, S. (2010) · Journal of Cell Science · doi:10.1242/jcs.065268 · Cited by 169
Hardikar, A. A., Marcus‐Samuels, B., Geras‐Raaka, E., Raaka, B. M., & Gershengorn, M. C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1232230100 · Cited by 162
Zaret, K. S., Watts, J. A., Xu, J., Wandzioch, E., Smale, S. T., & Sekiya, T. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.040 · Cited by 163
Fujitani, Y., Fujitani, S., Boyer, D. F., Gannon, M., Kawaguchi, Y., Ray, M., Shiota, M., Stein, R., Magnuson, M., & Wright, C. (2006) · Genes & Development · doi:10.1101/gad.1360106 · Cited by 181
Hedgehog signaling in pancreas development
Hebrok, M. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00331-3 · Cited by 157
Self-citationBardot, E., & Hadjantonakis, A. (2020) · Mechanisms of Development · doi:10.1016/j.mod.2020.103617 · Cited by 159
Leconte, I., Fox, J. C., Baldwin, H. S., Buck, C. A., & Swain, J. L. (1998) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199812)213:4 · Cited by 38
Pancreatic β Cell-specific Transcription of thepdx-1 Gene
Gerrish, K., GANNON, M. A., Shih, D. Q., Henderson, E., Stoffel, M., Wright, C. V. E., & Stein, R. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3485 · Cited by 155
Control of Cell Identity in Pancreas Development and Regeneration
Stanger, B. Z., & Hebrok, M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.074 · Cited by 158
Self-citationHedgehog signaling regulation of insulin production by pancreatic beta-cells.
Thomas, M. K., Rastalsky, N., Lee, J. H., & Habener, J. F. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2039 · Cited by 153
Stabilization of β-catenin induces pancreas tumor formation
Heiser, P., Cano, D., Landsman, L., Kim, G. E., Kench, J., Klimstra, D., Taketo, M., Biankin, A., & Hebrok, M. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.06.089 · Cited by 155
Self-citationPeterson, K. J., Cameron, R. A., Tagawa, K., Satoh, N., & Davidson, E. H. (1999) · Development · doi:10.1242/dev.126.1.85 · Cited by 138
Brolén, G., Heins, N., Edsbagge, J., & Semb, H. (2005) · Diabetes · doi:10.2337/diabetes.54.10.2867 · Cited by 140
An endothelial–mesenchymal relay pathway regulates early phases of pancreas development
Jacquemin, P., Yoshitomi, H., Kashima, Y., Rousseau, G. G., Lemaigre, F. P., & Zaret, K. S. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2005.11.023 · Cited by 140
Vaudin, P., Delanoue, R., Davidson, I., Silber, J., & Zider1, A. (1999) · Development · doi:10.1242/dev.126.21.4807 · Cited by 133
The notochord: structure and functions
Corallo, D., Trapani, V., & Bonaldo, P. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1897-z · Cited by 135
PDX1 is the cornerstone of pancreatic β-cell functions and identity
Ebrahim, N., Shakirova, K. S., & Dashinimaev, E. B. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1091757 · Cited by 134
Stomach Organ and Cell Lineage Differentiation: From Embryogenesis to Adult Homeostasis
Willet, S. G., & Mills, J. C. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.05.006 · Cited by 130
Bayha, E., Jørgensen, M. C., Serup, P., & Grapin‐Botton, A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005845 · Cited by 121
Notochord Cells in Intervertebral Disc Development and Degeneration
McCann, M. R., & Séguin, C. A. (2016) · Journal of Developmental Biology · doi:10.3390/jdb4010003 · Cited by 127
Retinoids signal directly to zebrafish endoderm to specify insulin -expressing β-cells
Stafford, D. A., White, R. J., Kinkel, M. D., Linville, A., Schilling, T. F., & Prince, V. (2006) · Development · doi:10.1242/dev.02263 · Cited by 118
Committing Embryonic Stem Cells to Early Endocrine Pancreas In Vitro
Ku, H. T., Zhang, N., Kubo, A., O'Connor, R., Mao, M., Keller, G. M., & Bromberg, J. S. (2004) · Stem Cells · doi:10.1634/stemcells.2004-0027 · Cited by 118
Pancreas: how to get there from the gut?
Edlund, H. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)00033-2 · Cited by 118
Signals from the neural crest regulate beta-cell mass in the pancreas
Nekrep, N., Wang, J., Miyatsuka, T., & German, M. S. (2008) · Development · doi:10.1242/dev.015859 · Cited by 115
Sonic hedgehog Is Required Early in Pancreatic Islet Development
diIorio, P. J., Moss, J. B., Sbrogna, J. L., Karlstrom, R. O., & Moss, L. G. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0573 · Cited by 115
Notochord Patterning of the Endoderm
Cleaver, O., & Krieg, P. A. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0214 · Cited by 114
Analysis of pancreatic development in living transgenic zebrafish embryos
Huang, H., Vogel, S. S., Liu, N., Melton, D. A., & Lin, S. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00408-7 · Cited by 114
Self-citationGofflot, F., Gaoua, W., Bourguignon, L., Roux, C., & Picard, J. J. (2001) · Developmental Dynamics · doi:10.1002/1097-0177(2000)9999:9999 · Cited by 27
Gleiberman, A. S., Fedtsova, N. G., & Rosenfeld, M. G. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9386 · Cited by 112
A conserved role for retinoid signaling in vertebrate pancreas development
Stafford, D. A., Hornbruch, A., Mueller, P. R., & Prince, V. (2004) · Development, Genes and Evolution · doi:10.1007/s00427-004-0420-6 · Cited by 114
The Mesenchyme Controls the Timing of Pancreatic β-Cell Differentiation
Duvillié, B., Attali, M., Bounacer, A., Ravassard, P., Basmaciogullari, A., & Scharfmann, R. (2006) · Diabetes · doi:10.2337/diabetes.55.03.06.db05-0839 · Cited by 109
GANNON, M. A., Gamer, L. W., & Wright, C. V. E. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0359 · Cited by 108
Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo
Roy, S., Qiao, T., Wolff, C., & Ingham, P. W. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00402-x · Cited by 107
Control of β-Cell Differentiation by the Pancreatic Mesenchyme
Attali, M., Stetsyuk, V., Basmaciogullari, A., Aiello, V., Zanta-Boussif, M., Duvillié, B., & Scharfmann, R. (2007) · Diabetes · doi:10.2337/db06-1307 · Cited by 91
Scharfmann, R. (2000) · Diabetologia · doi:10.1007/s001250051498 · Cited by 105
Bonal, C., Thorel, F., Ait‐Lounis, A., Reith, W., Trumpp, A., & Herrera, P. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.015 · Cited by 112
Shiraki, N., Yoshida, T., Araki, K., Umezawa, A., Higuchi, Y., Goto, H., Kume, K., & Kume, S. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0608 · Cited by 102
Stem Cells to Pancreatic β-Cells: New Sources for Diabetes Cell Therapy
Guo, T., & Hebrok, M. (2009) · Endocrine Reviews · doi:10.1210/er.2009-0004 · Cited by 106
Self-citationHedgehog signaling regulates expansion of pancreatic epithelial cells
Kawahira, H., Scheel, D. W., Smith, S. B., German, M. S., & Hebrok, M. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.01.008 · Cited by 97
Self-citationPancreas development and diabetes
St‐Onge, L., Wehr, R., & Grusst, P. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80044-6 · Cited by 97
Negative Regulation of Midline Vascular Development by the Notochord
Reese, D. E., Hall, C. E., & Mikawa, T. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00127-3 · Cited by 95
Metadata
- Authors
- Kim, S. K., Hebrok, M., & Melton, D. A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-11-01
- Volume
- 124
- Issue
- 21
- Pages
- 4243-4252
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1844743435
- Cited by
- 405
- References
- 59
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 8 · 2022: 1 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 12 · 2012: 14
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Oncology › Renal and related cancers
- Keywords
- notochord, endoderm, pancreatic development, dorsal pancreas, insulin, glucagon, carboxypeptidase A, chick embryo, in vitro recombination
- MeSH terms
- Animals, Cells, Cultured, Chick Embryo, Embryonic Induction, Endoderm, Nerve Tissue Proteins, Notochord, Pancreas, Transcription Factors, Signal Transduction, Biomarkers, Trans-Activators, Homeodomain Proteins, Gene Expression Regulation, Developmental, LIM-Homeodomain Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
