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Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
Abstract
Floor plate cells at the midline of the neural tube are specified by high-level activity of Sonic hedgehog (Shh) secreted by notochord, whereas motor neurons are thought to be specified by a lower level activity of Shh secreted in turn by floor plate cells. In Drosophila, the Gli zinc finger protein Cubitus interruptus functions as a transcription factor activating Hedgehog-responsive genes. We report that the expression of known Shh-responsive genes such as Ptc and Gli1 is downregulated in mutant mice lacking Gli2 function. Gli2 mutants fail to develop a floor plate yet still develop motor neurons, which occupy the ventral midline of the neural tube. Our results imply that Gli2 is required to mediate high level but not low level Shh activity and show that the development of motor neurons can occur in the absence of floor plate induction.
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Cites
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
Chiang, C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062
Gratzner, H. G. (1982) · Science · doi:10.1126/science.7123245 · Cited by 2,628
Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A., & McMahon, A. P. (1993) · Cell · doi:10.1016/0092-8674(93)90627-3 · Cited by 2,154
Pax-6, a murine paired box gene, is expressed in the developing CNS
Walther, C., & Gruss, P. (1991) · Development · doi:10.1242/dev.113.4.1435 · Cited by 1,255
Schaeren-Wiemers, N., & Gerfin-Moser, A. (1993) · Histochemistry · doi:10.1007/bf00267823 · Cited by 1,157
Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling
Ericson, J., Rashbass, P., Schedl, A., Brenner-Morton, S., Kawakami, A., van Heyningen, V, Jessell, T. M., & Briscoe, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80323-2 · Cited by 1,043
Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
Tsuchida, T., Ensini, M., Morton, S. B., Baldassare, M., Edlund, T., Jessell, T. M., & Pfaff, S. L. (1994) · Cell · doi:10.1016/0092-8674(94)90027-2 · Cited by 1,004
HNF-3β is essential for node and notochord formation in mouse development
Ang, S.-L., & Rossant, J. (1994) · Cell · doi:10.1016/0092-8674(94)90522-3 · Cited by 984
Self-citationPax-3, a novel murine DNA binding protein expressed during early neurogenesis.
Goulding, M. D., Chalepakis, G., Deutsch, U., Erselius, J. R., & Gruss, P. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb08054.x · Cited by 908
Roelink, H., Porter, J. A., Chiang, C., Tanabe, Y., Chang, D. T., Beachy, P. A., & Jessell, T. M. (1995) · Cell · doi:10.1016/0092-8674(95)90397-6 · Cited by 887
Ericson, J., Morton, S., Kawakami, A., Roelink, H., & Jessell, T. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81386-0 · Cited by 870
Goodrich, L. V., Johnson, R. L., Milenkovic, L., McMahon, J. A., & Scott, M. P. (1996) · Genes & Development · doi:10.1101/gad.10.3.301 · Cited by 824
Weinstein, D. C., Ruiz i Altaba, A., Chen, W. S., Hoodless, P., Prezioso, V. R., Jessell, T. M., & Darnell, J. E. (1994) · Cell · doi:10.1016/0092-8674(94)90523-1 · Cited by 783
Diversity and Pattern in the Developing Spinal Cord
Tanabe, Y., & Jessell, T. M. (1996) · Science · doi:10.1126/science.274.5290.1115 · Cited by 717
Hui, C.-C., & Joyner, A. L. (1993) · Nature Genetics · doi:10.1038/ng0393-241 · Cited by 706
Self-citationSasaki, H., Hui, C.-C., Nakafuku, M., & Kondoh, H. (1997) · Development · doi:10.1242/dev.124.7.1313 · Cited by 674
Self-citationAza-Blanc, P., Ramírez-Weber, F.-A., Laget, M.-P., Schwartz, C., & Kornberg, T. B. (1997) · Cell · doi:10.1016/s0092-8674(00)80292-5 · Cited by 661
Longitudinal organization of the anterior neural plate and neural tube
Shimamura, K., Hartigan, D. J., Martinez, S., Puelles, L., & Rubenstein, J. L. R. (1995) · Development · doi:10.1242/dev.121.12.3923 · Cited by 658
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
Lee, J., Platt, K. A., Censullo, P., & Altaba, A. R. (1997) · Development · doi:10.1242/dev.124.13.2537 · Cited by 634
Mo, R., Freer, A. M., Zinyk, D. L., Crackower, M. A., Michaud, J., Heng, H. H.-Q., Chik, K. W., Shi, X.-M., Tsui, L.-C., Cheng, S. H., et al. (1997) · Development · doi:10.1242/dev.124.1.113 · Cited by 605
Self-citationLiem, K. F., Tremml, G., & Jessell, T. M. (1997) · Cell · doi:10.1016/s0092-8674(01)80015-5 · Cited by 581
GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families
Vortkamp, A., Gessler, M., & Grzeschik, K.-H. (1991) · Nature · doi:10.1038/352539a0 · Cited by 545
The world according to bedgebog
Hammerschmidt, M., Brook, A., & McMahon, A. P. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(96)10051-2 · Cited by 541
GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome
Kang, S., Graham, J. M., Olney, A. H., & Biesecker, L. G. (1997) · Nature Genetics · doi:10.1038/ng0397-266 · Cited by 513
Marti, E., Bumcrot, D. A., Takada, R., & McMahon, A. P. (1995) · Nature · doi:10.1038/375322a0 · Cited by 491
Induction of midbrain dopaminergic neurons by Sonic hedgehog
Hynes, M., Porter, J. A., Chiang, C., Chang, D., Tessier-Lavigne, M., Beachy, P. A., & Rosenthal, A. (1995) · Neuron · doi:10.1016/0896-6273(95)90062-4 · Cited by 482
Hui, C.-C., Slusarski, D., Platt, K. A., Holmgren, R., & Joyner, A. L. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1097 · Cited by 480
Self-citationThe cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system
Hatta, K., Kimmel, C. B., Ho, R. K., & Walker, C. (1991) · Nature · doi:10.1038/350339a0 · Cited by 426
Sonic hedgehog Differentially Regulates Expression ofGLIandGLI3during Limb Development
Marigo, V., Johnson, R. L., Vortkamp, A., & Tabin, C. J. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0300 · Cited by 382
Alexandre, C., Jacinto, A., & Ingham, P. W. (1996) · Genes & Development · doi:10.1101/gad.10.16.2003 · Cited by 377
Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo
Martí, E., Takada, R., Bumcrot, D. A., Sasaki, H., & McMahon, A. P. (1995) · Development · doi:10.1242/dev.121.8.2537 · Cited by 336
Self-citationInduction of a specific muscle cell type by a hedgehog-like protein in zebrafish
Currie, P. D., & Ingham, P. W. (1996) · Nature · doi:10.1038/382452a0 · Cited by 320
Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptus
Domínguez, M., Brunner, M., Hafen, E., & Basler, K. (1996) · Science · doi:10.1126/science.272.5268.1621 · Cited by 318
The GLI-Kruppel family of human genes.
Ruppert, J. M., Kinzler, K. W., Wong, A. J., Bigner, S. H., Kao, F. T., Law, M. L., Seuanez, H. N., O'Brien, S. J., & Vogelstein, B. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.8.3104 · Cited by 299
HNF-3β as a regulator of floor plate development
Sasaki, H., & Hogan, B. L. M. (1994) · Cell · doi:10.1016/0092-8674(94)90176-7 · Cited by 294
Self-citationDrosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling
Akimaru, H., Chen, Y., Dai, P., Hou, D.-X., Nonaka, M., Smolik, S. M., Armstrong, S., Goodman, R. H., & Ishii, S. (1997) · Nature · doi:10.1038/386735a0 · Cited by 284
Hynes, M., Stone, D. M., Dowd, M., Pitts-Meek, S., Goddard, A., Gurney, A., & Rosenthal, A. (1997) · Neuron · doi:10.1016/s0896-6273(00)80344-x · Cited by 277
Pax-6 is involved in the specification of hindbrain motor neuron subtype
Osumi, N., Hirota, A., Ohuchi, H., Nakafuku, M., Iimura, T., Kuratani, S., Fujiwara, M., Noji, S., & Eto, K. (1997) · Development · doi:10.1242/dev.124.15.2961 · Cited by 235
Burrill, J. D., Moran, L., Goulding, M. D., & Saueressig, H. (1997) · Development · doi:10.1242/dev.124.22.4493 · Cited by 210
Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis
Ekker, S. C., Lynn McGrew, L., Lai, C.-J., Lee, J. J., von Kessler, D. P., Moon, R. T., & Beachy, P. A. (1995) · Development · doi:10.1242/dev.121.8.2337 · Cited by 203
Catching a Gli-mpse of Hedgehog
Ruiz i Altaba, A. (1997) · Cell · doi:10.1016/s0092-8674(00)80325-6 · Cited by 198
Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development
Büscher, D., Bosse, B., Heymer, J., & Rüther, U. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00656-4 · Cited by 192
Epstein, D. J., Martí, E., Scott, M. P., & McMahon, A. P. (1996) · Development · doi:10.1242/dev.122.9.2885 · Cited by 176
Mutation in GLI3 in postaxial polydactyly type A
Radhakrishna, U., Wild, A., Grzeschik, K., et al. (1997) · Nature Genetics · doi:10.1038/ng1197-269 · Cited by 174
Role of the floor plate in axonal patterning in the zebrafish CNS
Hatta, K. (1992) · Neuron · doi:10.1016/0896-6273(92)90027-b · Cited by 167
Schimmang, T., Lemaistre, M., Vortkamp, A., & Rüther, U. (1992) · Development · doi:10.1242/dev.116.3.799 · Cited by 165
Induction of motor neurons by Sonic hedgehog is independent of floor plate differentiation
Tanabe, Y., Roelink, H., & Jessell, T. M. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00130-8 · Cited by 163
Platt, K. A., Michaud, J. L., & Joyner, A. L. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00648-x · Cited by 153
Perrimon, N. (1995) · Cell · doi:10.1016/0092-8674(95)90503-0 · Cited by 144
Hepker, J., Wang, Q. T., Motzny, C. K., Holmgren, R. A., & Orenic, T. V. (1997) · Development · doi:10.1242/dev.124.2.549 · Cited by 139
Ishii, K., Oda, Y., Ichikawa, T., et al. (1990) · Molecular Brain Research · doi:10.1016/0169-328x(90)90092-r · Cited by 118
Altaba, A. R. I., Placzek, M., Baldassare, M., Dodd, J., & Jessell, T. M. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1216 · Cited by 117
Ohlen, T. L. V., Lessing, D., Nusse, R., & Hooper, J. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2404 · Cited by 114
Masuya, H., Sagai, T., Moriwaki, K., & Shiroishi, T. (1997) · Developmental Biology · doi:10.1006/dbio.1996.8457 · Cited by 112
Altaba, A. R. I., Jessell, T. M., & Roelink, H. (1995) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1995.1011 · Cited by 111
The Zinc Finger Protein GLI Transforms Primary Cells in Cooperation with Adenovirus E1A
Ruppert, J. M., Vogelstein, B., & Kinzler, K. W. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.3.1724 · Cited by 111
Effect of the notochord on proliferation and differentiation in the neural tube of the chick embryo
van Straaten, H. W. M., Hekking, J. W. M., Beursgens, J. P. W. M., Terwindt‐Rouwenhorst, E., & Drukker, J. (1989) · Development · doi:10.1242/dev.107.4.793 · Cited by 102
Sasaki, H., & Hogan, B. (1996) · Genes to Cells · doi:10.1046/j.1365-2443.1996.04004.x · Cited by 101
Self-citationgli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development
Walterhouse, D. O., Ahmed, M., Slusarski, D. C., et al. (1993) · Developmental Dynamics · doi:10.1002/aja.1001960203 · Cited by 96
Altaba, A. R. I., Cox, C. M., Jessell, T. M., & Klar, A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8268 · Cited by 87
[23] Detection of messenger RNA by in Situ hybridization to postimplantation embryo whole mounts
Conlon, R. A., & Herrmann, B. G. (1993) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(93)25026-x · Cited by 82
Gasca, S., Hill, D., Klingensmith, J., & Rossant, J. (1995) · Developmental Genetics · doi:10.1002/dvg.1020170206 · Cited by 73
Self-citationTremblay, P., Pituello, F., & Gruß, P. (1996) · Development · doi:10.1242/dev.122.8.2555 · Cited by 57
Marine, J., Bellefroid, E. J., Pendeville, H., MARTIAL, J. A., & Pieler, T. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00050-6 · Cited by 49
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Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
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Varjosalo, M., & Taipale, J. (2008) · Genes & Development · doi:10.1101/gad.1693608 · Cited by 1,217
Wang, B., Fallon, J. F., & Beachy, P. A. (2000) · Cell · doi:10.1016/s0092-8674(00)80678-9 · Cited by 1,014
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McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Dessaud, E., McMahon, A. P., & Briscoe, J. (2008) · Development · doi:10.1242/dev.009324 · Cited by 734
Metadata
- Authors
- Ding, Q., Motoyama, J., Gasca, S., Mo, R., Sasaki, H., Rossant, J., & Hui, C.-C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1998-07-15
- Volume
- 125
- Issue
- 14
- Pages
- 2533-2543
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1950508909
- Cited by
- 451
- References
- 64
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- closed
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