The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells
Abstract
piwi represents the first class of genes known to be required for stem cell self-renewal in diverse organisms. In the Drosophila ovary, piwi is required in somatic signaling cells to maintain germline stem cells. Here we show that piwi encodes a novel nucleoplasmic protein present in both somatic and germline cells, with the highly conserved C-terminal region essential for its function. Removing PIWI protein from single germline stem cells significantly decreases the rate of their division. This suggests that PIWI has a second role as a cell-autonomous promoter of germline stem cell division. Consistent with its dual function, over-expression of piwi in somatic cells causes an increase both in the number of germline stem cells and the rate of their division. Thus, PIWI is a key regulator of stem cell division – its somatic expression modulates the number of germline stem cells and the rate of their division, while its germline expression also contributes to promoting stem cell division in a cell-autonomous manner.
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Citations
Cites
Mechanisms of asymmetric cell division during animal development
Knoblich, J. A. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80085-3 · Cited by 87
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A germline-specific class of small RNAs binds mammalian Piwi proteins
Girard, A., Sachidanandam, R., Hannon, G. J., & Carmell, M. A. (2006) · Nature · doi:10.1038/nature04917 · Cited by 1,762
PIWI-interacting small RNAs: the vanguard of genome defence
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Juliano, C., Wang, J., & Lin, H. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132541 · Cited by 374
Self-citationDrosophila PIWI associates with chromatin and interacts directly with HP1a
Brower-Toland, B., Findley, S. D., Jiang, L., Liu, L., Yin, H., Dus, M., Zhou, P., Elgin, S. C. R., & Lin, H. (2007) · Genes & Development · doi:10.1101/gad.1564307 · Cited by 350
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Silencio/CG9754 connects the Piwi-piRNA complex to the cellular heterochromatin machinery
Sienski, G., Batki, J., Senti, K.-A., Dönertas, D., Tirian, L., Meixner, K., & Brennecke, J. (2015) · Genes & Development · doi:10.1101/gad.271908.115 · Cited by 185
Iwasaki, Y. W., Murano, K., Ishizu, H., Shibuya, A., Iyoda, Y., Siomi, M. C., Siomi, H., & Saito, K. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.06.008 · Cited by 131
Zhang, C., Robinson, B. S., Xu, W., Yang, L., Yao, B., Zhao, H., Byun, P. K., Jin, P., Veraksa, A., & Moberg, K. H. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.05.010 · Cited by 70
Metadata
- Authors
- Cox, D. N., Chao, A., & Lin, H.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-02-01
- Volume
- 127
- Issue
- 3
- Pages
- 503-514
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1845807280
- Cited by
- 546
- References
- 1
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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