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Cited by 657

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Distinct cortical migrations from the medial and lateral ganglionic eminences

Open access
Anderson, Stewart A., Marín, Oscar, Horn, Carrie, Jennings, Kelly, Rubenstein, John L. R.·2001·Development
DOI 10.1242/dev.128.3.353
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Abstract

Recent evidence suggests that projection neurons and interneurons of the cerebral cortex are generally derived from distinct proliferative zones. Cortical projection neurons originate from the cortical ventricular zone (VZ), and then migrate radially into the cortical mantle, whereas most cortical interneurons originate from the basal telencephalon and migrate tangentially into the developing cortex. Previous studies using methods that label both proliferative and postmitotic cells have found that cortical interneurons migrate from two major subdivisions of the developing basal telencephalon: the medial and lateral ganglionic eminences (MGE and LGE). Since these studies labeled cells by methods that do not distinguish between the proliferating cells and those that may have originated elsewhere, we have studied the contribution of the MGE and LGE to cortical interneurons using fate mapping and genetic methods. Transplantation of BrdU-labeled MGE or LGE neuroepithelium into the basal telencephalon of unlabeled telencephalic slices enabled us to follow the fate of neurons derived from each of these primordia. We have determined that early in neurogenesis GABA-expressing cells from the MGE tangentially migrate into the cerebral cortex, primarily via the intermediate zone, whereas cells from the LGE do not. Later in neurogenesis, LGE-derived cells also migrate into the cortex, although this migration occurs primarily through the subventricular zone. Some of these LGE-derived cells invade the cortical plate and express GABA, while others remain within the cortical proliferative zone and appear to become mitotically active late in gestation. In addition, by comparing the phenotypes of mouse mutants with differential effects on MGE and LGE migration, we provide evidence that the MGE and LGE may give rise to different subtypes of cortical interneurons.

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Metadata

Authors
Anderson, S. A., Marín, O., Horn, C., Jennings, K., & Rubenstein, J. L. R.
Venue
Development
Publisher
The Company of Biologists
Published
2001-02-01
Volume
128
Issue
3
Pages
353-363
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.128.3.353
OpenAlex
W2097053397
Cited by
657
References
49
FWCI
11.74
Type
journal article
Language
en
Open access
green

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