The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Directed differentiation of pluripotent cells to neural lineages: homogeneous formation and differentiation of a neurectoderm population
Open accessAbstract
During embryogenesis the central and peripheral nervous systems arise from a neural precursor population, neurectoderm, formed during gastrulation. We demonstrate the differentiation of mouse embryonic stem cells to neurectoderm in culture, in a manner which recapitulates embryogenesis, with the sequential and homogeneous formation of primitive ectoderm, neural plate and neural tube. Formation of neurectoderm occurs in the absence of extraembryonic endoderm or mesoderm and results in a stratified epithelium of cells with morphology, gene expression and differentiation potential consistent with positionally unspecified neural tube. Differentiation of this population to homogeneous populations of neural crest or glia was also achieved. Neurectoderm formation in culture allows elucidation of signals involved in neural specification and generation of implantable cell populations for therapeutic use.
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Citations
Cites
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Cited by
Mummery, C., Ward-van Oostwaard, D., Doevendans, P., Spijker, R., van den Brink, S., Hassink, R., van der Heyden, M., Opthof, T., Pera, M., de la Riviere, A. B., et al. (2003) · Circulation · doi:10.1161/01.cir.0000068356.38592.68 · Cited by 1,001
An extracellular matrix microarray for probing cellular differentiation
Flaim, C. J., Chien, S., & Bhatia, S. N. (2005) · Nature Methods · doi:10.1038/nmeth736 · Cited by 803
Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy
Wobus, A. M., & Boheler, K. R. (2005) · Physiological Reviews · doi:10.1152/physrev.00054.2003 · Cited by 782
Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation
Hiratani, I., Ryba, T., Itoh, M., Yokochi, T., Schwaiger, M., Chang, C.-W., Lyou, Y., Townes, T. M., Schübeler, D., & Gilbert, D. M. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060245 · Cited by 549
Formative pluripotency: the executive phase in a developmental continuum
Smith, A. (2017) · Development · doi:10.1242/dev.142679 · Cited by 474
Differentiation of mouse embryonic stem cells into a defined neuronal lineage
Bibel, M., Richter, J., Schrenk, K., Tucker, K. L., Staiger, V., Korte, M., Goetz, M., & Barde, Y.-A. (2004) · Nature Neuroscience · doi:10.1038/nn1301 · Cited by 450
Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis
Hiratani, I., Ryba, T., Itoh, M., Rathjen, J., Kulik, M., Papp, B., Fussner, E., Bazett-Jones, D. P., Plath, K., Dalton, S., et al. (2010) · Genome Research · doi:10.1101/gr.099796.109 · Cited by 323
Self-citationPrabhakaran, M. P., Venugopal, J. R., & Ramakrishna, S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.05.057 · Cited by 311
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Metadata
- Authors
- Rathjen, J., Haines, B. P., Hudson, K. M., Nesci, A., Dunn, S., & Rathjen, P. D.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2002-06-01
- Volume
- 129
- Issue
- 11
- Pages
- 2649-2661
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2142769704
- Cited by
- 162
- References
- 1
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
